Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This study is testing whether a non-invasive procedure using focused ultrasound can help adults with limb dystonia who haven't improved with medications or injections. Researchers will compare real treatment to a sham procedure in 34 participants to see if creating a tiny lesion …

This study aims to see if using an ultrasound machine to guide Botox injections helps people with cervical dystonia (a condition causing painful neck muscle spasms) more than standard injections. About 37 adults who already respond well to Botox will receive both types of injecti…

This study is testing whether a safe, fluorescent dye can help surgeons see brain tumors more clearly during surgery. The dye is given by IV and makes tumor tissue glow under a special microscope light, potentially helping doctors remove more of the cancer while sparing healthy b…

This study is testing a new, smarter biopsy needle designed to make brain tumor sampling safer and more accurate. The tool uses special lights and sound to help doctors see tumor tissue and avoid tiny blood vessels in real-time. Researchers will test it on about 20 tumor samples …

This study is testing whether a specific type of talk therapy can help people with chronic facial pain that has no clear physical cause. Sixty adults with this condition will be randomly assigned to receive either the new therapy or their usual care. The main goal is to see if th…

This study is testing whether using lower doses of anesthesia drugs during brain tumor surgery helps patients wake up faster and more clearly afterward. Researchers will monitor 100 adults having elective brain surgery to see if carefully controlled, lower-dose anesthesia leads t…

This study is testing if a dietary supplement designed to support gut health can help children with autism. Researchers want to see if the supplement, taken daily for one month, can reduce common stomach problems and improve related behaviors like sleep and emotional regulation. …

This study aims to translate and validate an English questionnaire about gastrointestinal symptoms into Italian for Parkinson's disease patients. Researchers will work with 190 Italian-speaking Parkinson's patients to create a reliable Italian version of the symptom assessment to…

This study aims to develop better ways to predict whether meningioma brain tumors will return after treatment. Researchers will analyze tumor tissue and blood samples from 210 patients to identify molecular markers that indicate recurrence risk. The goal is to create a blood test…

This study aims to understand how deep brain stimulation (DBS) affects brain networks in people with dystonia. Researchers will observe 15 patients who already have DBS implants that can record brain signals. The study involves brain scans and measurements to learn how DBS change…

This study aims to see if computer models that help doctors give the right amount of sedation drugs work as well after brain surgery as they do during surgery. Researchers will observe 42 adult patients who need sedation after elective brain surgery. They'll compare how accuratel…

This study aims to collect detailed information from 4,500 patients before and after various brain and spine surgeries. The goal is to identify which factors best predict a patient's recovery and quality of life after their operation. By standardizing how outcomes are measured ac…

This study aims to understand how cholesterol and its byproducts are involved in diseases like Alzheimer's and frontotemporal dementia. Researchers will analyze brain tissue, spinal fluid, and blood from about 80 people with these conditions and healthy controls. The goal is to s…

This study aims to discover new biological markers (biomarkers) for Amyotrophic Lateral Sclerosis (ALS) to help diagnose the disease earlier and track its progression. Researchers will analyze small nerve and skin samples, along with blood, from 400 participants, including people…

This study aims to better understand the health risks, especially cancer risk, in children who have a specific change in their PTEN gene. Researchers will follow 50 children and some of their affected family members in Italy for 5 years, performing regular check-ups and scans. Th…

This study is exploring if a bedside ultrasound scan of the brain can help doctors better understand and diagnose patients with severe consciousness disorders, like being in a coma or a minimally conscious state. Researchers will use ultrasound to look at brain structure and func…

This study aims to understand how vision and attention problems change over time in patients with brain tumors in the parietal lobe. Researchers will follow 40 patients before and after their tumor removal surgery, using simple paper-and-pencil tests to measure these difficulties…

This study aims to see if a special fluorescent dye used during brain surgery can help create a blood test for glioblastoma, a very aggressive brain tumor. Researchers will collect blood and urine samples from about 30 patients before and after they receive the dye to measure its…

This study aims to use Artificial Intelligence (AI) to create more consistent and effective care plans for adults with rare brain tumors. It will collect detailed health, thinking, and quality-of-life data from about 200 patients in Italy to find patterns that predict recovery af…

This study aims to understand if tracking a patient's heart rate patterns and brain wave activity after brain surgery can help predict who might develop complications. Researchers will observe 300 adult patients during their initial recovery in the post-anesthesia care unit. The …

This study aims to understand how migraine headaches affect thinking, memory, and mood. Researchers will examine 150 migraine patients to see how cognitive function changes during different headache phases and with different treatments. The goal is to create a clearer picture of …

This study aims to improve the diagnosis and understanding of rare diseases that cause strokes, which are often missed. It will enroll 500 people in Italy who have conditions like CADASIL or Moyamoya disease. Researchers will create a detailed patient registry and use virtual exp…

This study aims to understand how brain surgery for severe epilepsy affects patients' mental health and quality of life. Researchers will follow 180 adults with drug-resistant epilepsy who are eligible for surgery, tracking their mood, anxiety, and daily experiences over a year. …

This research study aims to understand if certain genes make a brain aneurysm more likely to burst. Researchers will collect blood samples and health information from 400 patients with brain aneurysms (half ruptured, half not) and 200 healthy people for comparison. The goal is to…

This study aims to better understand and distinguish between different types of inherited and immune-related nerve disorders, like Charcot-Marie-Tooth disease (CMT) and CIDP. Researchers will use specialized electrical tests and ultrasound scans on the nerves and muscles of about…

This study aims to understand the biological causes of Autism Spectrum Disorder (ASD) by collecting cells from 100 children with autism. Researchers will turn these cells into specialized brain cells in the lab to study their behavior and chemical makeup. The goal is to create a …