Less propofol during brain surgery may lead to quicker, safer awakening

NCT ID NCT06844838

Recruiting now Symptom relief Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether using lower doses of the anesthetic drug propofol during brain tumor surgery helps patients wake up more quickly and fully after the operation. Researchers will enroll 100 adults having elective brain surgery and monitor their recovery. The goal is to find the best balance between keeping patients asleep during surgery and ensuring a smooth, early awakening afterward.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propofol and remifentanil (anesthetic drugs)
What this could lead to: If it works, this could lead to a standard way to give anesthesia that helps brain surgery patients wake up sooner and more clearly.
What could go wrong: This is a small, early-phase study (100 people) at one hospital. The results may not apply to all patients, and the approach might not improve outcomes or could have unknown risks.

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Conditions

The condition(s) this trial relates to.

Pain supratentorial cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUPRATENTORIAL BRAIN TUMOR SURGERY

Contacts and locations

Locations

Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, 20133, Italy

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