Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This study tested a new way of delivering radiation for people with non-secreting pituitary adenomas that came back or remained after surgery. Instead of a single high dose, the radiation was given in five smaller daily doses. The goal was to see if this approach could control tu…

This study tested a personalized vaccine made from a patient's own tumor cells and immune cells (dendritic cells) for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the vaccine is safe and can help delay tumor growth. 76 participants …

This study tested whether adding acceptance and commitment therapy (ACT) to standard migraine treatment could reduce monthly headache days in people with high-frequency episodic migraine (9-14 headache days per month). Sixty-four adults were randomly assigned to either standard c…

This study tests whether ultrasound can help doctors better understand and treat people with disorders of consciousness, like coma or a minimally conscious state, after severe brain injury. Researchers will use ultrasound to look at brain structure and function, and also try low-…

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This completed study looked at 200 people with cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels, raising the risk of bleeding and cognitive decline. Researchers collected clinical data, brain scans, and samples of spinal fluid and bloo…

This completed study looked at how common cognitive (thinking) difficulties are in 150 people with myasthenia gravis. Researchers measured memory, attention, and other mental skills, and how these issues affect daily activities, work, and quality of life. The goal is to better un…

This completed observational study looked at 29 people with suspected normal pressure hydrocephalus (NPH), a condition where fluid builds up in the brain. Researchers used a special MRI technique called DTI-ALPS to measure the function of the brain's waste-clearing 'glymphatic sy…