Brain MRI may predict who benefits from hydrocephalus surgery
NCT ID NCT06857136
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed observational study looked at 29 people with suspected normal pressure hydrocephalus (NPH), a condition where fluid builds up in the brain. Researchers used a special MRI technique called DTI-ALPS to measure the function of the brain's waste-clearing 'glymphatic system.' They compared these scans to those of healthy volunteers and checked whether the MRI results could predict who would improve after a spinal tap or shunt surgery. The goal is to find a non-invasive way to guide treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to a non-invasive MRI method to better diagnose NPH and predict which patients will benefit from surgery.
What could go wrong
This is a small, completed observational study with only 29 participants. The findings are preliminary and need confirmation in larger trials before changing clinical practice.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, 20133, Italy