Chronic ulcer of skin

This study tests a special wound dressing called Hyalomatrix, made from hyaluronic acid, to see if it helps heal chronic venous leg ulcers faster than standard care alone. About 122 adults with leg ulcers that haven't healed for at least 4 weeks will take part. The main goal is t…

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive eit…

This study tests whether a special placental graft, used alongside standard wound care, helps close diabetic foot ulcers that won't heal on their own. About 350 adults with type 1 or 2 diabetes and a foot ulcer between 1 and 15 cm² will be randomly assigned to get the graft plus …

This study tests a device that uses light and magnets (COMS) to help heal chronic leg ulcers. About 122 people with venous leg ulcers will receive either standard care plus COMS or standard care alone. The goal is to see if the device speeds up wound healing and improves quality …

This study tests a special skin graft called NeoThelium FT to see if it can heal chronic pressure ulcers (bedsores) in 10 adults. The goal is complete wound closure within 16 weeks. Participants must have stage 2 or 3 ulcers on the pelvis or leg, without infection, and meet other…

This study is testing a new skin graft made from donated amniotic tissue to help heal venous leg ulcers, which are slow-healing wounds caused by poor blood flow. Ten adults with a leg ulcer between 1 and 30 square centimeters will receive the graft and be monitored for up to 13 w…

This Phase II trial tests whether placing antibiotic-releasing beads (STIMULAN VG) into the wound during surgery, plus standard antibiotics, works better than standard care alone for bone infections linked to stage IV pressure ulcers. About 60 adults will be randomly assigned to …

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This study tests a community-based care bundle for treating and preventing pressure injuries (bedsores) in older adults at home. 216 participants discharged from Singapore General Hospital will either receive the bundle (including special cushions, skin barriers, and caregiver tr…

This phase 2 trial tests whether injecting antibiotics directly into the tissue around chronic wounds helps them heal better than standard care alone. About 60 adults with non-healing wounds on their legs, arms, or trunk will either receive the antibiotic injections plus usual wo…

This study tests a new hydrogel made with plasma-activated water on chronic wounds like diabetic foot ulcers and pressure sores. Fifty adults will either get the gel or standard wound care for 12 weeks. Researchers will check if the gel helps wounds close faster and lowers bacter…

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This study compares two types of skin grafts (PelloGraft and SanoGraft) to standard wound care for healing diabetic foot ulcers and venous leg ulcers. About 180 adults with chronic wounds will be enrolled. The goal is to see if these grafts help wounds close completely within 12 …

This study tests whether a special wound dressing made from donated placental tissue, called NuShield, can help heal venous leg ulcers that won't close on their own. About 200 adults with these ulcers will receive either NuShield plus standard wound care or standard care alone. T…

This study tests a gel called EscharEx, made from pineapple enzymes, to remove dead tissue from hard-to-heal leg ulcers. About 216 adults with venous leg ulcers will receive either the active gel or a placebo. The goal is to see if the gel safely and effectively cleans the wound …

This study is testing a device called the TrueLok Elevate that uses a technique called transverse bone transport to help heal chronic lower limb ulcers. The device is attached to the leg and slowly moves a piece of bone to stimulate blood flow and tissue healing. Researchers will…

This study compares two versions of a special wound dressing for infected leg ulcers. One has an extra protective film on top. About 150 adults with infected leg ulcers will be randomly assigned to one dressing or the other, along with compression therapy. The main goal is to see…

This study tests whether a special vacuum-assisted wound system (NPWTi) helps heal chronic pressure sores better than standard wet-to-dry dressings. About 62 adults with stage 3 or 4 pressure sores on the tailbone or sitting bones will be randomly assigned to one of the two treat…

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach r…

This study is testing whether a gel made from a patient's own blood (platelet-rich fibrin) can help heal chronic leg ulcers that won't go away. About 40 adults over 35 with non-infected leg sores will receive the gel dressing. The goal is to see if the gel improves wound healing …

This study tests whether adding a placental-based skin substitute to standard wound care helps close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer present for 4 to 52 weeks will receive either the skin substitut…

This study tests a gel called ZKARE® for treating chronic ulcers that won't heal on their own. About 134 people with pressure sores, diabetic foot ulcers, or leg ulcers will either get the gel plus standard care, or standard care alone. The goal is to see if the gel helps wounds …

This study tests whether a special graft made from donated placental tissue, called XWRAP, can help heal diabetic foot ulcers that won't close with standard care alone. About 60 adults with type 1 or type 2 diabetes will receive either the graft plus standard wound care or standa…

This study tests whether a single-layer amniotic membrane (a thin tissue from donated placenta) plus standard wound care helps close nonhealing pressure ulcers better than standard care alone. About 100 adults with stage 3 or 4 pressure sores on the trunk will be followed for 20 …

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This study tests whether a special placental membrane called BR-AC, applied weekly, can help heal non-healing venous leg ulcers faster than standard care alone. About 60 adults with a leg ulcer between the knee and ankle will be randomly assigned to get either standard care plus …

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study tests whether special dressings made from placental membrane can help diabetic foot ulcers heal faster. About 30 adults with diabetes and a chronic foot ulcer will receive the placental dressing. Their healing progress will be compared to similar patients who received …

This study tests a wound dressing called Miro3D, made from pig liver tissue, to see if it helps heal hard-to-treat wounds like diabetic foot ulcers and pressure ulcers. Up to 20 adults will receive the dressing along with standard care for up to 12 weeks. Researchers will measure…

This study tests whether adding a special wound dressing called Miro3D to standard care helps diabetic foot ulcers heal faster. About 30 adults with Wagner Grade 1 foot ulcers will be randomly assigned to get either Miro3D plus standard care or standard care alone. The main goal …

This study tests a special wound covering made from donated placental tissue, called DermaBind TL, in 150 adults with diabetic foot or venous leg ulcers that won't heal. The goal is to see if the graft safely helps shrink or close the wound over 13 weeks. Participants must be 18-…

This study is testing a special soft cast for people with diabetic foot ulcers. The cast is a multi-layer wrap that cushions the foot and leg to help the wound heal. Researchers want to see if it works well, is comfortable, and safe. About 100 adults with diabetic foot ulcers wil…

This study tests a new antibacterial absorbable dressing on 30 adults with chronic non-healing wounds. The dressing is designed to break down in the body and help wounds heal faster. Researchers will measure how much the wound shrinks after 3 weeks and how many wounds fully close…

This study tests a special powder dressing called Altrazeal for treating bedsores (pressure ulcers) in stages 2, 3, and 4. About 300 adults will either get this new dressing or standard care. The main goal is to see if the new dressing needs fewer changes and helps wounds heal be…

This study tests whether a special tri-layer amnion graft or a single-layer amnion graft can help heal diabetic foot ulcers and venous leg ulcers that have not improved with standard care. About 165 adults with wounds between 2 and 25 cm² that have been open for over 4 weeks will…

This study tests whether adding live microalgae to a standard skin-regeneration scaffold helps deep wounds heal faster and with fewer infections. Twenty adults with full-thickness skin wounds will receive both the standard scaffold and the algae-enhanced version on different part…

This study explores whether a high-resolution ultrasound can better monitor healing in chronic wounds like diabetic foot ulcers. Ten participants will have their wounds scanned and biopsied to see if the ultrasound matches standard assessments. If it works, it could offer a painl…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study tests whether applying paraffin oil to the skin before using a tourniquet (a tight band that stops blood flow) during arm surgery can prevent skin injuries like redness, blisters, or burns. About 90 adults having elective upper arm surgery will be randomly assigned to …

This study compares two methods to prevent pressure ulcers (bedsores) in critically ill patients who must lie face-down (prone) for breathing support. About 262 ICU patients will receive either hyperoxygenated fatty acids or hydrocolloid dressings on at-risk areas. The goal is to…

This study works to prevent pressure injuries (bedsores) in hospitalized children and young people up to age 19. Researchers will improve a risk assessment tool to work better for those with dark skin tones. About 542 participants across 10 UK hospitals will help test the updated…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries in people with spinal cord injury. About 808 veterans from 7 VA clinics will use a survey to identify risks, and providers get a report with recommended actions. The goal is to see if the t…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests a new liquid treatment for chronic wounds like leg and foot ulcers. The goal is to clean the wound by removing dead tissue and bacteria, which may help it heal. About 80 people aged 60 and older will be randomly assigned to get either the new treatment or a stand…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study looks at whether continuously checking and adjusting the pressure of a breathing tube (laryngeal mask airway) can lower the chance of sore throat, hoarseness, and other throat problems in elderly patients after surgery. About 146 people aged 60 and older having non-eme…

This study tests whether using a virtual reality headset showing calming scenes (like puppies in a meadow) can reduce pain and discomfort for older adults in long-term care during wound dressing changes. Up to 20 residents will use VR for two weeks, with pain and mood measured be…

This study is checking how safe and effective a special dressing (3M V.A.C. Peel and Place) is when used with a standard wound vacuum therapy. About 90 adults with open wounds or surgical incisions will be treated and monitored. The goal is to see if the dressing helps wounds clo…

This early-stage study tests a topical spray called ELU42 on 15 adults with diabetic foot ulcers (Wagner grade 1-2) that have lasted 4 to 52 weeks. The spray is applied three times a week for six weeks. The main goals are to check safety and measure how much the wound shrinks. Th…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests a new two-sided pad (Debrisoft Duo) for cleaning wounds by removing dead tissue. About 104 adults with various wound types (like diabetic ulcers or burns) will be randomly assigned to the new pad or the current one-sided pad. The main goal is to see if the new pa…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

This study is testing a pad used to clean wounds, such as diabetic ulcers, leg ulcers, pressure sores, surgical wounds, and burns. The goal is to see if the pad safely removes debris and improves the wound bed right after use. About 184 adults with these types of wounds will take…

This study tests a device that delivers oxygen to chronic leg ulcers caused by vein problems. About 212 adults will get either the real oxygen therapy or a sham treatment, along with standard compression bandages, for up to 16 weeks. The main goal is to see if the oxygen therapy …

This study tests whether zinc oxide or moist exposed wound ointment (MEBO) works better for healing stage 2 pressure ulcers (bedsores). About 76 adults in hospital wards will receive daily treatment, and nurses will track wound healing using a standard scoring tool. The goal is t…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study tests whether a gamified metaverse-based training program helps nursing students learn more effectively about preventing and managing pressure ulcers (bedsores). Sixty second-year nursing students will be randomly assigned to either standard classroom teaching or stand…

This study looks at genetic and epigenetic changes in chronic wounds that don't heal normally. Researchers will compare tissue from the wound with blood samples from 256 adults to find genetic signatures linked to healing. The goal is to understand why some wounds heal and others…

This study tests whether an interactive e-book can improve home care nurses' knowledge and confidence in treating pressure injuries compared to standard PDF materials. About 132 nurses will use either the e-book or PDFs for one month and complete surveys before, right after, and …

This observational study follows 800 adults who receive Myriad™ during soft tissue reconstruction for wounds like abdominal dehiscence, pressure injuries, or anal fistulas. Researchers track healing time, complications, and side effects to understand how well the material works i…

This study follows 50 people whose diabetic foot ulcers healed in a previous trial. They will use a BlueDrop foot scanner at home each morning to take photos and thermal images, which are sent to a nurse. The goal is to see how often the ulcers come back and whether remote monito…

This study is for people with wounds that have developed hypergranulation (overgrown tissue that slows healing). Researchers will take photos and use a new assessment tool to grade the severity. About 100 adults and children in the UK will take part. The goal is to create a stand…

This study tests whether an AI-powered mobile app can help ICU nurses more accurately identify and stage pressure injuries (bedsores) compared to standard visual checks. About 90 nurses will be split into two groups: one using the AI tool, the other doing manual assessments. Thei…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This early study tests a new sensor called E-SWEAT that fits inside a prosthetic leg socket. It measures sweat, pressure, and temperature to see how these factors affect skin health. Sixteen adults with below-knee amputations will wear the sensor while walking and doing a yoga po…

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This study is testing whether a new imaging device called MIMOSA Pro can measure oxygen levels in leg tissue as accurately as standard tests like ankle-brachial index or Doppler ultrasound. Researchers will compare the device's readings to those from traditional methods in 60 adu…