Chronic ulcer of skin

This study looks at how well a product made from donated placental tissue helps close hard-to-heal wounds, such as diabetic foot ulcers and venous leg ulcers. Researchers will review medical records of 50 people who received this treatment to see how many wounds fully closed with…

This early study tested a single topical dose of stem cells (XSTEM-VLU) in 6 people with difficult-to-heal venous leg ulcers. The goal was to check safety and see if the treatment helps wounds close faster when added to standard care. Participants were followed for 10 weeks after…

This study tested using cyanoacrylate glue to close off faulty veins that cause painful leg ulcers. 38 people with venous leg ulcers received the glue treatment. The goal was to see if the procedure is safe and helps ulcers heal faster.

This study tests whether using telemedicine (remote doctor visits) helps heal chronic wounds better than usual in-person care. Adults with long-lasting wounds in the Languedoc-Roussillon region of France are randomly assigned to telemedicine or standard treatment. The main goal i…

This study tested a new way to treat venous leg ulcers, which are slow-healing wounds on the lower leg. Researchers used ultrasound to push hyaluronic acid gel into the wound and compared it to standard care in 64 patients. The goal was to see if this combination speeds up healin…

This study looked at whether special wraps made from human amniotic membrane can help heal chronic wounds like diabetic foot ulcers, venous leg ulcers, and pressure ulcers. Researchers reviewed data from 500 patients who either received the membrane wraps or standard wound care. …

This study tested two types of special mattresses—the Fluid Immersion Simulation (FIS) system and the Air Fluidized Bed (AFB)—to see which helps heal surgically closed pressure ulcers (bedsores) better. Eighty adults with stage III or IV bedsores were randomly assigned to one mat…

This study tested whether adding placental tissue grafts to standard wound care helps close diabetic foot and venous leg ulcers faster. 292 adults with nonhealing ulcers received either standard care alone or standard care plus a graft. The main goal was to see if more ulcers clo…

This study followed 191 adults with chronic leg or foot ulcers that hadn't improved for at least 6 months. They received a gel called CACIPLIQ20 added to standard wound care. Researchers tracked how many wounds fully closed within 20 weeks and checked for side effects. The goal w…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study tested a special wound dressing called MicroMatrix Flex on 25 adults with deep or tunneled wounds, such as pressure injuries, diabetic ulcers, or infected wounds. The goal was to see how safely and quickly the dressing helped close these wounds over 12 weeks. Researche…

This study tested whether adding carbon dioxide (CO₂) therapy to standard wound care helps heal recurrent diabetic foot ulcers. Thirty adults with diabetes and hard-to-heal ulcers received either standard care alone or standard care plus 20 sessions of CO₂ therapy over 4 weeks. T…

This study tested a wound patch called Oasis ECM on 41 people with non-healing sores. The patch is made from natural material to help wounds heal. Researchers measured how much the wounds closed and how patients felt about their quality of life.

This study tested whether a special dressing made from a patient's own platelets (platelet-rich plasma) helps chronic wounds heal better than a standard saline dressing. One hundred adults with long-lasting skin ulcers, including diabetic foot ulcers, took part. The goal was to s…

This study tested a new approach for treating severe bedsores (pressure injuries) in patients aged 55 and older. The treatment combined ultrasonic debridement (using sound waves to clean the wound) with photon therapy (light treatment) plus standard wound care. Out of 118 partici…

This study tested a special wound dressing called Symphony™ against standard care for people with diabetic foot ulcers that won't heal. 143 adults with mild to moderate ulcers took part. The goal was to see if Symphony™ helps more ulcers close completely within 12 weeks and how q…

This pilot study tested a staged application of two wound dressings (Endoform and Symphony) on 44 adults with chronic diabetic foot ulcers. The goal was to see if the treatment could fully close the wound within 12 weeks. Researchers measured healing rates, wound size reduction, …

This study tested a new way to help heal chronic wounds on the legs or feet of people with diabetes. The treatment involves applying carbon dioxide gas directly to the wound to improve blood flow and oxygen release. 120 adults with diabetes and non-healing ulcers took part to see…

This phase 2b trial tested a one-time application of a cell therapy made from donor skin cells (Allo-APZ2-CVU) in 159 people with chronic venous leg ulcers that hadn't healed despite standard care. The goal was to see if it could shrink or close these wounds better than a placebo…

This study looked at 240 adults with chronic or acute wounds to confirm that a silver-coated dressing (Silver II Non-Woven) is safe and works as intended. Researchers checked for signs of infection and asked clinicians how easy the dressing was to use. The dressing is already on …

This study looked at a silver alginate wound dressing (Silvercel) in 56 adults with chronic or acute wounds that were infected or at high risk. Over 6 weeks, doctors checked wound healing and any side effects. The goal was to confirm the dressing is safe and works as intended.

This study tested a borate-based bioactive glass wound matrix (Mirragen) plus standard care against standard care alone for diabetic foot ulcers. 148 adults with diabetes and a foot ulcer were enrolled. The main goal was to see if the glass dressing helped more wounds close compl…

This phase 2 pilot study tested a topical ointment called MEBO on venous leg ulcers. Only 5 people took part, and they were randomly assigned to get either MEBO or standard compression bandages. The main goal was to see if the ulcer healed completely within 8 weeks. Because the s…

This study tested whether a tri-layer amnion/chorion/amnion graft (Artacent-AC) plus standard care helps heal chronic diabetic foot ulcers better than standard care alone. 30 adults with diabetes and non-healing foot sores took part. The main goal was to see if the wound fully cl…

This study tested two types of skin substitutes for treating venous leg ulcers, which are slow-healing sores caused by poor blood flow in the legs. Sixty adults with these ulcers received either a collagen-based skin substitute or a dehydrated human amnion/chorion membrane, both …

This study tested whether a beta-blocker eye drop called timolol, applied directly to the wound, can help heal venous leg ulcers that have not improved with standard care. Forty-two adults with ulcers lasting at least 24 weeks received either timolol plus standard wound care or s…

This study tested a special nursing strategy to prevent pressure sores in patients with severe lung problems who need to lie face down (prone position). The trial included 160 adults in intensive care who were on breathing machines. The strategy involved protecting the eyes, tilt…

This study tested a special camera called the MolecuLight DX that uses fluorescence to measure the size of skin wounds. 34 adults with various types of wounds (like diabetic foot ulcers) took part. The goal was to see if the device measures wound area more accurately than a stand…

This study compared an automatic ABPI device (MESI MD) with the standard manual device (Huntleigh Dopplex) in 46 patients with lower limb ulcers. The goal was to see if the automatic device gives similar scores and ulcer classifications, potentially reducing waiting times and dis…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This study tested two special pillows—a fluidized positioner and a memory foam pillow—to see which better prevents pressure injuries on the heads of children in the pediatric intensive care unit. Thirty-two children on ventilators were enrolled. The goal is to find a simple way t…

This study tested the safety of a special silicone dressing placed on the lower back of hospital patients at risk for pressure injuries (bedsores). 67 adults took part, and the dressing was used as part of a standard prevention plan for up to 7 days. The main goal was to see if t…

This study looked at whether a powered alternating pressure air mattress can prevent pressure ulcers (bedsores) in patients at medium to high risk. 90 adults in nursing homes and long-term care used the mattress for up to 35 days. Researchers tracked how many developed at least a…

This study tested a mobile app designed to teach caregivers of bedridden patients how to prevent pressure injuries (bedsores). The app included educational modules, daily care tracking, and a way to ask a nurse questions. Researchers wanted to see if using the app for six months …

This study tested whether a silver-impregnated foam dressing prevents skin complications better than a standard foam dressing in children who had a tracheostomy. Fifty children were randomly assigned to one of the two dressings and followed for one month. The goal was to see whic…

This study looked at whether teaching caregivers how to prevent pressure ulcers (bedsores) can lower the risk for patients receiving home care. The training covered skin care, repositioning, and pressure relief methods. Researchers measured patients' risk levels before and after …

This study tested whether nursing interventions—like regularly changing a patient's position, keeping skin clean and moisturized, and avoiding pressure on bony areas—can prevent pressure ulcers (bedsores) in immobile stroke patients. 128 patients at high risk for bedsores took pa…

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tested whether taking fish oil supplements (EPA and DHA) could help heal chronic venous leg ulcers in adults aged 55 and older. The idea was that fish oil might reduce inflammation at the wound site, allowing the ulcer to heal. Researchers measured changes in blood mar…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study tested whether changing how fast pressure increases during hyperbaric oxygen therapy (HBOT) can lower the chance of ear pain and injury. Over 1,500 people receiving HBOT were randomly assigned to one of two compression schedules. The goal was to see if a non-linear (sl…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study looked at whether two silicone dressings (RespoSorb Silicone and RespoSorb Silicone Border) help heal long-lasting leg and foot wounds. 80 adults with venous leg ulcers or diabetic foot ulcers took part. The main goal was to see if the dressings reduce wound size, and …

This study tested a chemical gel that dries out wound debris against standard scraping (curettage) for cleaning venous leg ulcers. 80 participants with ulcers at least 6 weeks old were included. The goal was to see which method is safer and more effective at reducing wound size a…

This study looked at how well a special dressing called Aquacel WSF Ribbon works for healing foot ulcers and other wounds in everyday medical practice. Researchers reviewed the medical records of 214 people who used this dressing. The main goal was to see how long it took for wou…

This study tested whether listening to music during wound dressing changes can help reduce pain and anxiety in people with venous leg ulcers. 97 patients were split into three groups: one listened to Turkish instrumental music, one to Western music without lyrics, and one had no …

This study tested two special wound dressings—AQUACEL® Ag+ Extra™ and Cutimed® Sorbact®—in 203 adults with venous leg ulcers. The goal was to see which one helps wounds heal better over 12 weeks. Participants had ulcers for at least 2 months and received compression therapy. The …

This study tested whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific body points, could reduce kinesiophobia (fear of movement) and pressure sore risk in 148 adults who had obesity surgery. Participants received EFT sessions, and researchers me…

This study looked at whether a special interactive dressing (UrgoStart Plus) used with compression bandages can help heal venous leg ulcers faster than standard dressings. Sixty adults with chronic leg ulcers were treated for up to 12 weeks. The goal was to see if the new dressin…

This study tested whether a face-to-face training session on pressure ulcer prevention improves the knowledge of caregivers of palliative care patients. 70 caregivers participated, and their knowledge was measured before and after training. The goal was to see if this simple educ…

This study tested whether using genetic information to guide surgical cleaning (debridement) could improve healing in people with hard-to-heal venous leg ulcers. Researchers analyzed genes and proteins from wound samples before and after the procedure. The goal was to see if this…

This completed study from Israel examined 4,500 ICU patients to see if intermittent pneumatic compression (IPC) devices, which are used to prevent dangerous blood clots, might also cause pressure sores. The researchers focused on sores around the ankles and other bony areas. The …

This study tested whether a Spanish pressure injury risk scale, called EVARUCI, works well in Turkish intensive care units. Researchers translated it and checked its accuracy in 100 adult ICU patients without existing bedsores. The goal was to give nurses a reliable way to spot p…

This study tested whether playing an escape room game helps nursing students learn about pressure ulcers (bedsores) better than just listening to a lecture. 51 senior nursing students took part. The game group showed improved knowledge right after and one month later compared to …

This study looked at medical records of 500 adult ICU patients to see if computer algorithms could predict who might develop pressure injuries (bedsores). The researchers used data like lab results and nursing notes to test different prediction methods. No treatments or patient c…

This study tested a training program for 30 intensive care nurses to improve their knowledge and care for medical device-related pressure injuries (like sores from tubes or masks). Nurses learned through a structured program and were tested before, right after, and one month late…

This study looked at how doctors in the UK currently diagnose and manage venous leg ulcers. Researchers surveyed 135 primary care doctors and vascular specialists to understand current practices and what guidelines are needed. The goal is to find the most effective and cost-effic…

This study tested a Turkish version of the CALCULATE scale, a tool to predict pressure injuries (bedsores) in intensive care patients. Researchers followed 76 adults in the ICU, checking their risk daily with both the new scale and the standard Braden scale. The goal was to see i…

This completed study tested two ways of dressing central venous catheters in 78 intensive care patients: one using gauze and tape, the other using a clear, medicated patch. The goal was to see which method leads to fewer medical device-related pressure injuries at the insertion s…

This study tested whether online training sessions could help wheelchair users learn how to prevent pressure injuries (also called bedsores). Researchers split 78 wheelchair users into two groups: one received three online training sessions over two weeks, while the other did not…

This study looked at how compression therapy changes oxygen levels in the skin of people with leg ulcers that involve both arteries and veins. Researchers measured oxygen before and during compression in 38 adults. The goal was to better understand how compression works and how w…

This study looked at 82 intensive care patients to see how the time they spend in one position affects their risk of developing pressure injuries (bedsores). Researchers checked skin changes like redness, bruising, and moisture, and used a standard risk scale. The goal was to fin…

This completed study from Versailles Hospital looked back at 200 medical reports of adults with skin injuries like cuts, scrapes, burns, and leg ulcers. The goal was to see how well pain was controlled during treatment. Researchers also interviewed some patients and staff to chec…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study looked back at photos from a previous trial to confirm how well two types of wound dressings helped close venous leg ulcers. Researchers checked if wounds had fully healed (100% skin coverage) by 12 weeks. The goal was to make sure the original results were accurate by…

This study looked at whether placing a small compress under the plastic connector of a child's IV tube can prevent pressure sores. About 360 children from 1 month to 18 years old took part. Researchers compared the usual method (no compress) with the compress method to see which …

This study tested whether video-based training helps caregivers of patients at risk for pressure injuries. 270 caregivers were split into three groups: video training, standard verbal training, or routine care. Researchers measured changes in knowledge, attitudes, and caregiving …

This study collected fluid from the wounds of 13 people with hard-to-heal leg ulcers. Researchers analyzed the fluid to see how it affects skin cells and bacteria. The goal was to learn more about why some wounds don't heal, not to test a new treatment.

This study tested whether a smartphone app called MyDerm can help patients and doctors monitor chronic leg wounds from home. 25 adults with a single leg wound that had lasted more than 6 weeks took part. Patients used the app to take photos of their wound and answer questions abo…

This study tested a computer program called ACE that helps nurses decide which products to use for treating chronic wounds. Researchers compared outcomes when nurses used ACE versus their usual approach in 73 patients across 18 clinics. The goal was to see if the tool improves he…

This study looked at how powered ankle prostheses change the pressure inside the prosthetic socket and the health of the residual limb in people with below-knee amputations. Six adults who already use a standard prosthetic leg walked on level ground with different types of prosth…

This study tested whether an automatic device (IntelliCuff) or manual checks by nurses better maintain safe air pressure in breathing tubes for 32 children in intensive care. The goal was to see which method keeps pressure in the ideal range and reduces nurse workload. Results wi…

This study measured the pressure on the tailbone (sacral area) from two different hospital bed systems: a low air loss mattress and a standard hospital mattress. 18 healthy adults were tested lying flat and with the head of the bed raised 30 degrees. The goal was to see which bed…

This study tested whether an intelligent computer program could help nurses better prevent and manage bedsores (pressure injuries) in hospitalized patients. Over 75,000 patients took part, and researchers compared data before and after using the program to see if it improved care…

This study followed 104 people with venous leg ulcers to see which factors were linked to complete healing after 24 weeks. Researchers looked at medical history, wound size, and also psychological and social factors like mood and self-esteem. The goal was to find better ways to p…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…

This study tested whether a jigsaw-style group learning method helps nursing students better understand pressure ulcer prevention. Sixty-two senior nursing students were split into two groups: one learned using the jigsaw technique, the other with traditional lectures. Researcher…