Can a common antibiotic beat yaws? new trial puts linezolid to the test
NCT ID NCT05764876
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either linezolid for 7 days or a single dose of azithromycin, and researchers track whether their skin lesions heal and if the infection clears from the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Linezolid (oral tablet)
What this could lead to
If linezolid works as well as azithromycin, it could provide an alternative treatment for yaws, especially in areas where antibiotic resistance is a concern.
What could go wrong
This is a single trial with 384 participants, so results may not apply broadly. Linezolid may cause side effects like nausea or diarrhea, and it is not yet proven to be as effective as the standard treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Department of Health
Port Moresby, Papua New Guinea