New hope for rare blood cancer: targeted drug trial opens

NCT ID NCT04996875

Recruiting now Disease control Sponsor: Cogent Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen May 03, 2026 · Last updated May 15, 2026 · Updated 2 times

Summary

This study tests a new drug called CGT9486 (bezuclastinib) in people with advanced systemic mastocytosis, a rare and serious blood disorder. The drug aims to control the disease by targeting a specific genetic mutation. About 140 adults with aggressive forms of the condition will take part to see if the drug is safe and effective.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AKH Wien, Universitatsklinikum
ACTIVE_NOT_RECRUITING

Vienna, 1090, Austria
AOU San Giovanni di Dio e Ruggi dAragonia
ACTIVE_NOT_RECRUITING

Salerno, 84131, Italy
Azienda Ospedaliero Universitaria Careggi
ACTIVE_NOT_RECRUITING

Florence, 50134, Italy
Azienda Ospidaleira Universitaria Integrata Verona
WITHDRAWN

Verona, 37124, Italy
CHU de Liege
WITHDRAWN

Liège, 4000, Belgium
Centre Hospitalier Universitaire (CHU) de Poitiers
ACTIVE_NOT_RECRUITING

Poitiers, 86000, France
Centre Hospitalier Universitaire (CHU) de Toulouse
ACTIVE_NOT_RECRUITING

Toulouse, 31300, France
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic Taussig Cancer Center
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44106, United States
Columbia University Irving Medical Center
WITHDRAWN

New York, New York, 10032, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Galiz Research
WITHDRAWN

Hialeah, Florida, 33016, United States
Gold Coast University Hospital
RECRUITING

Southport, Queensland, 4215, Australia
Guy's Hospital - NHS Foundation Trust
RECRUITING

London, London, SE1 9RT, United Kingdom
Hospital Universitario Ramón y Cajal
ACTIVE_NOT_RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08740, Spain
Huntsman Cancer Institute - University of Utah Health
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS Azienda Ospedaliero Universitaria di Bologna
ACTIVE_NOT_RECRUITING

Bologna, 40138, Italy
Institut Català d'Oncologia - Hospital Duran i Reynals
ACTIVE_NOT_RECRUITING

Barcelona, 08908, Spain
Leeds Teaching Hospitals NHS Trust
RECRUITING

Leeds, LS9 7TF, United Kingdom
MUSC Health University Medical Center
RECRUITING

Charleston, South Carolina, 29425, United States
Mayo Clinic Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Necker-Enfants Malades Hospital
ACTIVE_NOT_RECRUITING

Paris, 75015, France
Nepean Hospital
RECRUITING

Kingswood, New South Wales, 2747, Australia
Oslo University Hospital
ACTIVE_NOT_RECRUITING

Oslo, 0450, Norway
Peter MacCallum Cancer Centre
RECRUITING

Melbourne N., Victoria, 3051, Australia
Public University Hospital No. 1 in Lublin
ACTIVE_NOT_RECRUITING

Lublin, 20-400, Poland
Rush University Medical Center
WITHDRAWN

Chicago, Illinois, 60612, United States
St. Michael's Hospital - Unity Health Toronto
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
Stanford Cancer Institute
RECRUITING

Stanford, California, 94305, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
UKSH Campus Lubeck
ACTIVE_NOT_RECRUITING

Lübeck, 23562, Germany
University College London Hospital - NHS Foundation Trust
RECRUITING

London, NW1 2BU, United Kingdom
University Hospital Aachen
ACTIVE_NOT_RECRUITING

Aachen, 52074, Germany
University Medical Center Groningen
ACTIVE_NOT_RECRUITING

Groningen, 9713, Netherlands
University of Alabama at Birmingham (UAB) Hospital
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35233, United States
University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G 2G3, Canada
Universitätsklinikum Freiburg
ACTIVE_NOT_RECRUITING

Freiburg im Breisgau, 79104, Germany
Universitätsklinikum Mannheim
ACTIVE_NOT_RECRUITING

Mannheim, 68167, Germany
Universitätsspital Basel
RECRUITING

Basel, 4031, Switzerland
Winship Cancer Institute - Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED SYSTEMIC MASTOCYTOSIS (ADVSM) AGGRESSIVE SYSTEMIC MASTOCYTOSIS (ASM) MAST CELL LEUKEMIA (MCL) SM WITH AN ASSOCIATED HEMATOLOGIC NEOPLASM (SM-AHN)