New hope for tough blood cancers: experimental drug MGD024 enters human testing

NCT ID NCT05362773

Ongoing Disease control Sponsor: MacroGenics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This early-stage study tests a new drug called MGD024 in people with certain blood cancers (like leukemia and lymphoma) that came back or didn't get better with standard treatments. The main goal is to find the safest dose and watch for side effects. About 130 adults will receive the drug for up to a year, and doctors will check how the body responds.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia aggressive systemic mastocytosis B-cell acute lymphoblastic leukemia Blastic Plasmacytoid Dendritic Cell Neoplasm CD4+/CD56+ hematodermic neoplasm chronic myelogenous leukemia, BCR-ABL1 positive classic Hodgkin lymphoma hairy cell leukemia Leukemia, B-Cell Leukemia, Myelogenous, Chronic, BCR-ABL Positive Mastocytosis, Systemic myelodysplastic syndrome Myelodysplastic Syndromes precursor B-cell acute lymphoblastic leukemia systemic mastocytosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM CHRONIC MYELOID LEUKEMIA CLASSICAL HODGKIN LYMPHOMA LEUKEMIA ACUTE MYELOID LEUKEMIA, B-CELL LEUKEMIA, HAIRY CELL MASTOCYTOSIS, AGGRESSIVE SYSTEMIC MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

Colorado Blood Cancer Network

Denver, Colorado, 80218, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
START - Midwest

Grand Rapids, Michigan, 49503, United States
South Austin Medical Center

Austin, Texas, 78704, United States
University of Maryland, Greenbaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.