Could a Once-a-Week acne pill replace daily antibiotics?
NCT ID NCT06225570
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a weekly dose of isotretinoin (a vitamin A derivative) to daily tetracycline antibiotics for treating moderate acne. Researchers want to see if the weekly approach works just as well, with fewer side effects and less reliance on antibiotics. The trial will enroll 50 people aged 12 and older and track acne improvement, side effects, and patient satisfaction over four months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isotretinoin (a vitamin A derivative) taken weekly, compared to standard tetracycline antibiotics taken daily
What this could lead to
If it works, this could offer a new, safer way to treat moderate acne with fewer side effects and less antibiotic use.
What could go wrong
This is a very early (Phase 1) trial with only 50 people, so results may not hold up in larger studies. Isotretinoin has known side effects like dry skin and mood changes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29403, United States
Contact Phone: •••-•••-••••