Can acne drug harm the eyes? new study investigates

NCT ID NCT07753811

Completed Knowledge-focused Sponsor: Benha University Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and after six months of treatment. The goal is to better understand and potentially predict dry eye as a side effect of isotretinoin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral isotretinoin
What this could lead to: If this trial succeeds, it could help doctors predict or manage dry eye as a side effect of isotretinoin, improving quality of life for acne patients.
What could go wrong: This is a small, early-stage observational study, so results may not apply broadly. It does not test a new treatment, and findings may not change clinical practice.

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Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris dry eye syndrome Meibomian Gland Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACNE VULGARIS DRY EYE DISEASE (DED) MEIBOMIAN GLAND DYSFUNCTION (DISORDER)

Contacts and locations

Locations

faculty of Medicine

Banhā, 13518, Egypt

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