Skin disorder

This study tests two doses of an experimental oral drug, LXE408, against a standard treatment (miltefosine) for localized cutaneous leishmaniasis, a parasitic skin disease. About 250 adults in the Americas will take the medicine for several weeks. The main goal is to see if the s…

This study tests whether a newer antifungal cream (luliconazole) works better than the standard treatment (ketoconazole) for pityriasis versicolor, a common fungal skin infection that causes light or dark patches. About 86 adults with the infection will use one of the two creams …

This study tests a new chickenpox vaccine called NBP608 in about 780 children aged 1 to 12 years. The vaccine is compared to licensed vaccines to see how well it triggers immunity and if it is safe. Children receive one or two shots, and researchers monitor their immune response …

This study tests a new chickenpox vaccine in 300 healthy children aged 1 to 12 years. All children will receive one dose of the vaccine. Researchers will check if the vaccine triggers a strong immune response and is safe to use.

This study tests a new vaccine designed to prevent hand, foot, and mouth disease (HFMD) and herpangina in children aged 6 months to 5 years. About 6,000 healthy children will receive either the vaccine or a placebo to see if it safely protects against four common virus types that…

This study tests a new vaccine that protects against measles, mumps, rubella, and chickenpox (MMRV) in healthy children aged 15 months to 6 years. It compares the new vaccine to an already approved one (ProQuad) to see if it works as well and is safe. About 1,200 children will re…

This study tests a new mRNA vaccine called SYS6017 to prevent shingles, a painful rash caused by the chickenpox virus. About 800 healthy adults aged 40 and older will receive either the new vaccine, a placebo, or an existing shingles vaccine. Researchers will check how well the v…

This early-stage trial tests a new vaccine designed to protect against hand, foot, and mouth disease caused by two common viruses. About 144 healthy volunteers aged 6 months to 59 years will receive either the vaccine or a placebo. The main goal is to check safety and see how wel…

This study tests an oral medication called remibrutinib for adults with moderate-to-severe papulopustular rosacea, a skin condition causing red bumps and pustules on the face. The drug works by blocking a protein involved in inflammation. Researchers will measure whether it reduc…

This study tests whether a cream containing ruxolitinib (Opzelura) combined with corticosteroid injections or pills can improve facial vitiligo. It includes people aged 12 and older with active, non-segmental vitiligo affecting the face. Participants use the cream twice daily and…

This study tests whether combining a fractional laser with a biostimulator (poly-L-lactic acid) can repair sun-damaged skin better than either treatment alone. The goal is to improve skin health and potentially lower the risk of skin cancer. Researchers will use AI-assisted imagi…

This early-stage trial is testing an experimental drug called KK2223 in 72 adults with T-cell lymphoma (a type of blood cancer) that has returned or not responded to prior treatments. The main goals are to check the drug's safety, find the best dose, and see how the body processe…

This study compares two treatments for actinic keratoses—rough, scaly spots that can turn into skin cancer—on the arms. One treatment uses a light-sensitizing gel followed by blue light (photodynamic therapy), while the other uses a two-step chemical peel. About 60 adults with sp…

This pilot study tests whether adding manual lymphatic drainage (a gentle massage technique) to standard wound care can help heal pressure injuries (bedsores) in patients hospitalized in intensive care. The trial randomly assigns 60 adults with a pressure injury on the sacrum (ta…

This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway invo…

This study tests a new approach for treating keloids—thick, raised scars that can be painful and itchy. The treatment combines wide-band ultrasound with a traditional Chinese medicine preparation applied to the skin. The goal is to soften scar tissue, reduce symptoms, and prevent…

This study tests whether a rapamycin cream, applied after laser treatment, can improve the appearance of port wine stain birthmarks in children aged 10 and under. Thirty participants will receive laser therapy plus either a low or high dose of the cream or a placebo cream for 12 …

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This study compares the standard antifungal drug itraconazole alone versus itraconazole combined with isotretinoin (an acne medication) in adults with tinea corporis or cruris (ringworm of the body or groin). The goal is to see if the combination shortens treatment time and impro…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This study tests whether Maraviroc, a drug currently used for HIV, can reduce muscle inflammation and improve function in adults with myositis that hasn't responded to standard treatments. Ten participants will take a daily 300mg tablet for 12 weeks and undergo muscle biopsies an…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study compares two topical medications—clascoterone cream and adapalene gel—for treating mild acne vulgaris. Researchers will enroll 60 people aged 12 to 35 with mild acne and randomly assign them to use one of the treatments for 12 weeks. The goal is to see which treatment …

This pilot study tests whether fecal microbiota transplantation (FMT) can improve moderate to severe hidradenitis suppurativa (HS), a painful skin condition. Researchers will give 24 adults a single FMT and track changes in their skin lesions over 12 weeks. The goal is to see if …

This phase 3 study tests the long-term safety and effectiveness of remibrutinib, an oral drug, in 710 adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses. Participants have already completed a prior remibrutinib study. …

This phase 2 trial tests whether adding an experimental immune-boosting pill (PRTX007) to standard immunotherapy (pembrolizumab) before surgery can improve outcomes for people with stage III melanoma. About 48 adults with resectable melanoma will take the combination for 9 weeks …

This study tests two surgical techniques to treat stable white patches on the skin that are not caused by vitiligo. Both methods involve transplanting the patient's own skin cells, followed by laser therapy to boost color return. Twenty-two adults will each receive both treatment…

This study explores whether giving people with mild-to-moderate eczema a straightforward treatment plan using only Opzelura cream helps them stick to their medication routine. Participants apply the cream twice daily until their skin clears, then as needed. Some participants also…

This study compares two standard steroid treatments for hypertrophic lichen planus, a chronic skin condition that causes thick, intensely itchy plaques. Fifty adults will be randomly assigned to apply a strong steroid cream twice daily for 12 weeks or receive steroid injections i…

This early-stage trial tests a new topical film called ZYG24004 for athlete's foot (tinea pedis). About 64 adults with the infection will apply the film to their feet once or twice. The main goals are to check safety, how the body processes the drug, and whether it can clear the …

This phase 2a trial tests whether a daily pill called ACT-777991 can help return color to the face of adults with non-segmental vitiligo. About 30 participants will take either the drug or a placebo for 24 weeks. Researchers will measure changes in skin color using a standard sco…

This Phase 3 trial tests whether the oral drug nerandomilast can slow disease progression in adults with systemic sclerosis (scleroderma). About 448 participants will be randomly assigned to receive either nerandomilast or a placebo twice daily for up to 4 years. Researchers will…

This study tests a cream called benvitimod (tapinarof) for people with cutaneous T-cell lymphoma, a rare skin cancer that causes red patches and itching. The cream is non-steroidal and works by targeting a specific receptor in skin cells. About 35 adults with the disease will app…

This study tests a drug called nemolizumab in toddlers aged 6 to 23 months with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams or ointments. The goal is to see how the drug moves through the body, if it is safe, and if it helps control the conditio…

This study tests whether adding a fractional CO₂ laser to standard Glucantime injections helps heal skin sores from leishmaniasis faster and with less scarring. About 150 adults will be randomly assigned to get either the injection alone or the injection plus laser. Researchers w…

This study tests whether adding axelopran, a drug that blocks opioid side effects in the gut, to the immunotherapy nivolumab can help people with advanced melanoma that no longer responds to PD-1 inhibitors. The trial includes about 28 adults with unresectable or metastatic cutan…

This pilot study tests the drug ivonescimab in people with advanced or metastatic cutaneous angiosarcoma, a rare and aggressive skin cancer. Participants must have already received chemotherapy with paclitaxel or docetaxel. The study aims to see if ivonescimab is safe and can shr…

This study looks at how safe and effective Takhzyro is for teenagers and adults with hereditary angioedema (HAE) in everyday medical care in South Korea. HAE is a rare condition that causes sudden swelling under the skin or inside the body. The study will track side effects and h…

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This trial tests whether the drug sebetralstat can prevent swelling attacks in people with hereditary angioedema (HAE) when taken before a medical procedure. Participants aged 12 and older with HAE type I or II will take sebetralstat just before their scheduled procedure. The mai…

This study tests if a special wound dressing called MIRRAGEN® can help heal venous leg ulcers (open sores on the legs caused by poor blood flow) faster than standard care alone. About 110 adults with these ulcers will either get MIRRAGEN® plus standard care or standard care only.…

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This Phase 3 trial tests YCANTH, a topical solution containing cantharidin (a substance from blister beetles), against a placebo for treating common warts. About 300 people aged 2 and older with at least one wart on their body (excluding certain areas) will receive either the act…

This study follows 470 adults with chronic spontaneous urticaria (hives) who are starting remibrutinib, a new drug. Researchers will track how well it controls symptoms and any side effects over two years in real-world clinics. The goal is to see if remibrutinib works as well out…

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne…

This study tests an experimental pill called ENV-294 for adults with moderate-to-severe atopic dermatitis (eczema). About 200 participants will take either one of three doses of ENV-294 or a placebo daily for 12 weeks. Researchers will measure changes in eczema severity, symptoms…

This study will test whether a special electrical stimulation device (FREMS) plus the drug phenytoin can help heal chronic ulcers in people with diabetes. Twenty-six participants will be split into two groups: one gets the new combo, the other gets standard care. Researchers will…

This study looks at 120 adults with moderate-to-severe psoriasis who take secukinumab, a biologic drug. It compares two maintenance schedules: the standard every-4-week injection versus a non-standard schedule (longer intervals or lower dose). The goal is to see which schedule ke…

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This trial tests a drug called ivarmacitinib in people with Behçet's disease who have not improved with standard treatments. Ivarmacitinib blocks a key inflammation pathway (JAK-STAT) to reduce symptoms. Participants take the drug daily for 24 weeks, and researchers monitor their…

This study will test whether a newer cream called tapinarof works better than the standard betamethasone cream for mild-to-moderate plaque psoriasis. About 120 adults will use one of the two creams daily for up to 12 weeks. The main goal is to see how many people get at least a 7…

This early-phase trial is testing whether adding sitagliptin, a diabetes drug, to the immunotherapy pembrolizumab is safe and can help people with advanced kidney cancer or melanoma whose cancer has stopped responding to standard treatment. The study will first find the safest do…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests an experimental drug called D-2570 in 160 adults with non-segmental vitiligo, a condition that causes white patches on the skin. Participants take either D-2570 or a placebo pill once daily for 24 weeks, with an optional 24-week extension. The goal is to see if t…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink melanoma tumors in people with stage IIIB to IV melanoma. About 35 adults will receive the drugs, then have surgery to remove any remaining cancer. The main goal is to see…

This early-stage trial tests a gel called LUT017 on chronic wounds like venous leg ulcers. The gel is applied once a week for up to 8 weeks to see if it's safe and might help wounds heal. About 12 to 18 adults with a leg wound that hasn't healed for at least 4 weeks will take par…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests if injecting polidocanol (a medicine that reduces blood flow) into keloids and hypertrophic scars can make them flatter and less noticeable. About 90 people with scars that are less than a year old will receive either polidocanol or a standard steroid injection. …

This pilot study will test a new type of radiation called FLASH radiotherapy for people with cutaneous lymphoma, a rare skin cancer. Ten participants will receive a single, ultra-fast dose of radiation to their skin lesions. The main goal is to see if the treatment is safe and to…

This early-phase trial tests whether a topical cream called squaric acid dibutyl ester (SADBE) can safely reduce pigment-producing cells in large congenital moles before they are surgically removed. Thirty adults with these birthmarks will apply the cream or a placebo for several…

This study tests whether freezing precancerous skin spots (cryotherapy) followed by a medicated ointment (tirbanibulin) works better than freezing alone for actinic keratosis on the scalp and forehead. About 59 adults with at least 8 spots will receive the combo treatment or a pl…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This Phase 2 trial tests whether small interfering RNA (siRNA) microneedle patches can improve the appearance of earlobe keloid scars after laser surgery. About 158 adults with earlobe keloids will receive either standard steroid injections alone or steroid injections plus the si…

This study looks at whether adding stem cells from the shoulder bursa and platelet-rich plasma (PRP) to standard rotator cuff repair helps the tendon heal better. About 200 adults with full-thickness supraspinatus tears will be followed for a year. Researchers will compare those …

This study tests a new cream called VC005 for people aged 12 and older with mild to moderate atopic dermatitis (eczema). The goal is to see if the cream can clear or nearly clear the skin rash better than a cream without medicine. About 360 participants will use either the study …

This study tests a cream called ruxolitinib on children aged 2 to 11 with a common type of vitiligo (white patches on skin). The goal is to see if the cream can safely bring back skin color over 24 weeks. About 20 children will apply the cream daily and visit the clinic for check…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study compares two types of compression bandages for treating venous leg ulcers, which are slow-healing wounds on the lower leg. About 386 adults will receive either the new Mepi Press 2 or the standard UrgoK2 bandage for up to 12 weeks. The goal is to see if the new bandage…

This early study will test whether a daily omega-3 cream and serum can change the balance of bacteria on eczema-affected skin. Ten adults with eczema will apply the treatment for 14 days, and researchers will measure four types of bacteria before and after. The study is explorato…

This Phase 3 study tests whether lebrikizumab, an injectable drug, can safely and effectively treat nummular eczema in adults who haven't gotten enough relief from topical steroids or can't use them. About 270 participants will receive either lebrikizumab or a placebo injection. …

This Phase 2 trial tests whether adding benralizumab (a drug already used for asthma) to standard corticosteroid treatment can help people with DRESS syndrome recover faster and spend fewer days in the hospital. DRESS is a rare, severe allergic reaction to certain medications tha…

This study tests a new drug called Bmab1800 to see if it works like the approved drug Keytruda in people with stage IIB, IIC, or III melanoma after their tumor has been removed by surgery. About 138 adults will get either Bmab1800 or Keytruda, and researchers will compare how the…

This study tests a special stent (a small mesh tube) placed in veins to treat blockages, narrowing, or leg ulcers caused by poor blood flow. About 150 adults will receive the stent and be followed to see if it keeps the vein open and safe. The goal is to improve blood flow and re…

This study tests a new type of radiation called FLASH therapy, which delivers the entire dose in milliseconds instead of minutes. The goal is to see if it can treat skin cancers (squamous cell and basal cell carcinomas) just as well as standard radiation but with fewer side effec…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study compares two oral medications, methotrexate and tofacitinib, for treating chronic plaque psoriasis. About 88 adults with moderate to severe psoriasis who haven't improved with topical treatments will be randomly assigned to one of the drugs and followed for six months.…

This study compares a new dressing called POLTX_Fiber to a standard one for chronic wounds like leg ulcers and pressure sores. Sixty adults with moderate-to-heavy wound drainage will be followed for 30 days. Researchers will track healing, infection, pain, and patient satisfactio…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This early-phase study tests whether the drug efgartigimod (VYVGART) can lower harmful collagen VII antibodies and improve wound healing in people with two rare blistering skin conditions: recessive dystrophic epidermolysis bullosa (RDEB) and epidermolysis bullosa acquisita (EBA)…

This phase 1/2 trial tests whether a patient's own stem cells, taken from belly fat and grown in a lab, can heal leg ulcers caused by severe peripheral artery disease. 40 participants will either receive stem cell injections and a special cell-containing dressing, or standard hyd…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This early-stage study tests a wound spray (APR-TD011) on skin lesions caused by cutaneous T cell lymphoma. Researchers want to see if the spray can reduce harmful bacteria (Staphylococcus aureus) on the skin and if it is well tolerated. The study will include 30 adults with earl…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether shining a special low-level laser on chronic leg ulcers can help them heal faster. 96 adults with venous leg ulcers will receive either real laser treatment plus standard compression, or a sham laser plus compression, twice a week for 16 weeks. The goal i…

This study tests an experimental pill called LW402 in 180 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The pill works by blocking certain immune signals. Participants will take one of three doses or a placebo for up to 52 weeks to see if …

This study compares two treatments for stable vitiligo: microneedling with a topical solution (minoxidil) alone versus microneedling with the same solution plus narrow-band UV light therapy. Thirty adults with stable non-segmental vitiligo will be enrolled. The goal is to see if …

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests whether combining an anti-IL-17A/F antibody (bimekizumab) with a non-ablative fractional laser can safely reduce symptoms of mild to moderate hidradenitis suppurativa, a chronic skin condition causing painful lumps. Fifty adults will receive the combination every…

This study tests a device that moves a small piece of shinbone to improve blood flow and help heal chronic foot ulcers in people with diabetes. One hundred adults with stubborn ulcers that haven't healed after 12 weeks will be enrolled. The goal is to see if this procedure, added…

This study tests whether wearing compression stockings alone can prevent repeat episodes of erysipelas (a bacterial skin infection) as well as the usual approach of antibiotics plus stockings. About 200 adults who have had at least two infections in the same leg will be randomly …

This study looks at whether switching to a pill called ivarmacitinib can help people with moderate-to-severe eczema (atopic dermatitis) who did not get enough relief from standard injectable drugs. About 300 adults will take the pill for 16 weeks. The goal is to see if their skin…

This pilot study tests whether injecting dexpanthenol (a vitamin B5 derivative) under the skin around chronic wounds can help them heal faster. 40 adults with diabetic foot ulcers, venous leg ulcers, or arterial ulcers will receive either standard wound care alone or standard car…

This study tests two oral medications—roflumilast and methotrexate—for psoriasis in skin folds and genital areas, which are often hard to treat with creams alone. Fifty-six adults with topical-resistant psoriasis will take one of the two pills for 16 weeks. Researchers will measu…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This early-stage trial tests a stem cell injection (HS_SW01) in 21 adults with systemic sclerosis, a disease where the immune system attacks the body, causing skin hardening and organ damage. The main goal is to see if the treatment is safe and tolerable. Researchers will also ch…

This phase 3 trial tests whether RSS0393 ointment can improve plaque psoriasis compared to a placebo. About 600 adults with mild-to-moderate psoriasis will apply the ointment daily for 8 weeks. The main goal is to see if more people achieve clear or almost-clear skin with RSS0393…

This study tests a new drug called MG-K10 in 180 teens aged 12-17 with moderate-to-severe eczema that hasn't responded well to creams. The drug is given as a shot every two weeks for a year. Researchers will check if it clears skin and reduces itching better than a placebo.

This early-stage trial will test a new drug called firsekibart in 30 people with systemic sclerosis (scleroderma), a disease that causes skin thickening and organ damage. Firsekibart is an antibody that blocks a protein involved in inflammation. The study will measure changes in …

This study tests a combination of four chemotherapy drugs (aclarubicin, cyclophosphamide, vincristine, and prednisone) in people with cutaneous T-cell lymphoma that has come back or not responded to prior treatment. The trial has two phases: first, finding the safest dose of acla…

This study tests the drug adalimumab in 30 Chinese children aged 4 to 17 with severe plaque psoriasis that hasn't improved with creams or light therapy. The goal is to see if adalimumab can safely reduce skin symptoms like redness and scaling. The main measure is how many childre…

This Phase II trial tests a new drug called VG712 against an existing drug, mogamulizumab, in about 386 people with advanced mycosis fungoides, a rare type of skin lymphoma. VG712 is designed to kill cancerous immune cells by blocking protein production. The study aims to see if …

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This early study tests a new drug called HN2302, which aims to create CAR-T cells inside the body to target and control autoimmune diseases like lupus and scleroderma. The trial will enroll 12 adults to check safety and see if the treatment works. It is a first step, so results w…

This study tests whether adding a bone-marrow concentrate injection during routine back surgery helps the spinal disc heal better. About 90 adults with a herniated disc will get either surgery alone or surgery plus the injection. Researchers will use MRI scans and pain questionna…

This early-stage study tests a new drug called cizutamig in about 20 adults with IgE-mediated allergies, including food allergies. The main goal is to see if the drug can safely lower IgE levels, which are antibodies that trigger allergic reactions. Researchers will also monitor …

This Phase 3 trial tests whether combining two drugs, tofacitinib and imatinib, can safely clear the painful pustules of palmoplantar pustulosis (PPP), a rare chronic skin disease on the palms and soles. About 135 adults with moderate-to-severe PPP will receive either the combo o…

This study tests whether a special wound covering made from donated human placental tissue, called NeoThelium FT, can help heal venous leg ulcers when used with standard care. About 132 adults with open leg ulcers that haven't healed well will be randomly assigned to get either t…

This study tests a vaccine called KSD-101 in 80 people with blood cancers linked to the Epstein-Barr virus (EBV). The vaccine uses a patient's own immune cells to target EBV and cancer. Researchers want to see if it can shrink tumors or keep the disease from coming back.

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study is testing a gel called CABTREO, which combines three acne-fighting ingredients (clindamycin, adapalene, and benzoyl peroxide), in children aged 9 to 11 with moderate to severe acne. The goal is to see if it is safe and works well over 12 weeks. About 100 kids will app…

This study tests whether exosomes from umbilical cord stem cells can safely help restore skin color in adults with vitiligo. 96 participants with active or stable vitiligo will receive either exosome infusions or injections alongside standard light therapy and ointment. The goal …

This study compares two prescription creams, tacrolimus and crisaborole, for treating mild to moderate eczema in children and teens aged 2 to 20. Both creams are steroid-free and aim to control inflammation without the side effects of long-term steroid use. Over 8 weeks, 72 parti…

This phase 2 trial tests three immune-boosting drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery in 20 people with advanced but removable melanoma. The goal is to see if the combination is safe and can shrink tumors, potentially improving outcomes. Participants m…

This study tests an ointment called HW211026 in 80 adults with actinic keratosis, rough skin patches caused by sun damage. The goal is to see if the ointment can completely clear these lesions on the face. Participants will use the ointment and be monitored for safety and effecti…

This study tests whether a wound covering made from donated human placenta, called NeoThelium FT, helps heal chronic pressure ulcers (bedsores) better than standard care alone. About 148 adults with pressure ulcers on the pelvis or legs will be randomly assigned to receive either…

This study tests whether adding a special cell secretion (called secretome) to standard light therapy helps restore skin color better in people with vitiligo. About 150 adults with stable vitiligo will receive either light therapy alone, or light therapy plus secretome applied th…

This study tests a combination of darolutamide, hormone therapy, and a lower dose of the chemotherapy drug docetaxel in men with metastatic hormone-sensitive prostate cancer. The goal is to see if this approach can keep PSA levels very low (below 0.2 ng/mL) at 24 weeks while redu…

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can shrink tumors in people with a specific type of skin cancer called acral melanoma, which is stage IIB or III and can be removed. About 30 adults will receive the drug combi…

This Phase 2 study tests a new biologic drug called AK139 in 168 adults with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams. Participants will receive either AK139 or a placebo by injection. The study aims to see if AK139 can safely clear skin and …

This study tests three different gels for mild-to-moderate acne: a standard clindamycin-retinoid combo, a clindamycin-retinoid-dexamethasone combo, and a gel made from stem-cell secretions (secretome). About 189 people will use one of the three gels for 8 weeks. Researchers will …

This phase 2 trial tests two drugs, cemiplimab and cetuximab, given before surgery to people with advanced skin cancer that is hard to remove. The goal is to shrink the tumor enough to make surgery easier or even unnecessary. The study will enroll 27 participants across three sit…

This early-stage trial will test whether injecting adalimumab (Humira) into the eye during Boston KPro surgery is safe for 8 patients with severe corneal damage. The study focuses on side effects and tolerability, not yet on how well it works. It is for people who have run out of…

This study tests whether the drug Bimzelx (bimekizumab) can improve skin symptoms in adults with pityriasis rubra pilaris, a rare condition causing red, scaly patches. Researchers will enroll 12 participants and measure how many achieve at least 75% improvement in skin severity a…

This study tests whether omega-3 supplements or a special anti-demodex eyelid cleanser can help treat and prevent chalazia (styes) in children aged 4 to 17. All 168 participants will use warm compresses, and they will be split into three groups: one adds omega-3 fish oil and stan…

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests whether adding metformin (a diabetes drug) to the standard psoriasis treatment secukinumab works better than secukinumab alone for overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. About 186 participants will be randomly assigned to r…

This phase 3 trial tests whether a cream called SD-101 can help close wounds in children with epidermolysis bullosa (EB), a condition that causes fragile, blistering skin. About 80 children aged 1 month to 12 years will apply the cream or a placebo to their whole body for 2 month…

This phase 3 trial tests whether injecting a patient's own blood (autologous whole blood therapy) can help control chronic hives that don't respond to high-dose antihistamines. 40 adults with chronic idiopathic urticaria will receive either the blood injections plus antihistamine…

This Phase 2 trial tests a new cell therapy called RAPA-201 for people with advanced melanoma that has stopped responding to PD-(L)1 inhibitors. The therapy uses a patient's own immune cells, modified to resist the drug rapamycin, and is given along with chemotherapy. The study a…

This phase 2 trial tests the drug everolimus in 67 people with vascular anomalies (abnormal blood vessels) that haven't responded to standard treatments. The goal is to shrink the lesions and improve symptoms. Participants take everolimus daily for 6 months, with doses adjusted b…

This phase 3 study tests an injectable drug called MG-K10 for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams. About 498 participants will receive either MG-K10 or a placebo to see if it safely reduces skin redness, itc…

This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …

This study tests whether adding low-dose steroid pills to a standard vitiligo skin-cell transplant surgery helps prevent a pale ring around the treated area and improves overall skin color restoration. About 60 people with stable vitiligo will be randomly assigned to get surgery …

This trial tests AVT32-DRL_PB, a biosimilar (copy) of the cancer drug Keytruda, in 120 people with stage IIB/C or III melanoma whose tumors were fully removed. Half get the biosimilar, half get Keytruda, every 3 weeks. The main goal is to see if drug levels in the blood are simil…

This Phase 2 trial tests an experimental drug called CMS-D001 in 160 adults with moderate to severe atopic dermatitis (eczema) that hasn't responded well to creams. Participants will take one of three doses of the drug or a placebo daily for several weeks. The main goal is to see…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study tests whether adding FoundationDRS Solo to usual wound care helps heal chronic foot ulcers in people with diabetes. About 124 adults with a nonhealing ulcer will get either the new treatment plus standard care or standard care alone for 12 weeks. The main goal is to se…

This study tests whether clearing Staphylococcus aureus bacteria from the skin can reduce eczema severity in people with atopic dermatitis. Researchers will enroll 100 participants aged 6 and older with moderate-to-severe disease. The goal is to see if decolonization improves ski…

This study tests whether shining a specific red light on bedsores (pressure ulcers) can help them heal faster. About 46 ICU patients with stage II bedsores will either get the light treatment plus standard care, or standard care alone, for 14 days. Researchers will track wound si…

This study tests a combination of two immunotherapy drugs, nivolumab and relatlimab, in people with advanced melanoma that hasn't been treated before. The goal is to see if the combination is safe and helps shrink tumors. About 30 adults and teens (ages 12 and up) in India will t…

This phase 2 trial tests a combination of two immune-boosting drugs, L19IL2 and L19TNF, injected directly into skin tumors. It is for people with advanced cutaneous squamous cell carcinoma whose cancer has worsened despite or who cannot tolerate standard immunotherapy. Up to 92 p…

This study tests a cream called clascoterone (1%) against a placebo in 692 people aged 12 and older with moderate to severe acne. Participants apply the cream to their face twice daily for 12 weeks. The goal is to see if the cream clears acne better than a placebo, with fewer sid…

This Phase 3 trial in Ethiopia will compare four different drug regimens against the standard treatment for cutaneous leishmaniasis, a parasitic skin disease. 900 patients aged 4 to 65 will be hospitalized and treated for up to 28 days, with follow-up for 6 months. The goal is to…

This phase 2 trial tests a new drug combination, L19IL2/L19TNF, injected directly into skin tumors. It is for people with advanced basal cell carcinoma that has worsened despite or cannot tolerate standard treatments. The study will enroll 92 participants and track how many respo…

This early-stage trial tests a new drug called HB0043, a bispecific antibody that targets two inflammatory proteins (IL-17A and IL-36R) linked to acne. About 21 adults with moderate to severe facial acne will receive either the drug or a placebo. The main goal is to check safety …

This study tests whether special dressings made from donated human umbilical cord tissue, used along with standard wound care, can help close hard-to-heal leg ulcers faster than standard care alone. About 272 adults with venous leg ulcers that have not healed after 4 to 52 weeks …

This study tests whether two skin substitutes made from donated human umbilical cord tissue can help close hard-to-heal diabetic foot ulcers. About 272 adults with diabetes and a foot ulcer will receive either standard wound care alone or standard care plus weekly applications of…

This study tests a new cream made with tiny nanoparticles of the drug apremilast for people with mild to moderate plaque psoriasis. Thirty-six adults will apply the cream twice daily for 12 weeks, and researchers will compare it to a standard steroid cream and a combination of bo…

This phase 2 study tests an injection called SHR-1139 in 20 adults with pyoderma gangrenosum, a rare condition causing painful skin ulcers. The goal is to see if the drug can completely close the ulcers and how safe it is. Researchers will also measure how the body processes the …

This study looks at how safe and effective a dehydrated human placenta tissue product is for healing chronic wounds like diabetic foot ulcers, venous leg ulcers, and pressure ulcers. Researchers will review medical records of 300 adults whose wounds were treated with this product…

This study compares two steroid-free ointments—crisaborole and tacrolimus—for treating mild-to-moderate eczema in 148 Pakistani patients aged 2 and older. Researchers will measure skin improvement and side effects over 8 weeks to see which works better and is safer. The goal is t…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This study tests an experimental tablet called CMS-D001 for adults with moderate to severe plaque psoriasis. About 540 participants will receive either the drug or a placebo to see if it improves skin symptoms like redness, scaling, and thickness. The goal is to measure how many …

This study tests a drug called cosibelimab in 80 people with advanced skin cancer who also have a kidney transplant or a blood cancer. The drug works by helping the immune system attack cancer cells. Researchers will check if the tumors shrink and monitor for side effects.

This Phase II trial tests QLS12010, an oral capsule, in 102 adults with moderate-to-severe hidradenitis suppurativa (HS), a painful skin condition. The study has two parts: an open-label proof-of-concept phase and a placebo-controlled dose-ranging phase. Participants must have tr…

This study tests if intense pulsed light (IPL) is a safe and effective way to treat chalazion, a common eyelid lump. About 40 adults with an inflamed chalazion will receive IPL or a control treatment. The main goal is to see if the lump shrinks by at least 80% four weeks after th…

This study looks at whether removing keloids surgically and then applying a radioactive patch (32P) can prevent them from returning. About 401 people with keloids will get this treatment and be checked every 6 months for 2 years. The goal is to see how well the combo works and wh…

This Phase 2 trial tests whether a personalized cell therapy called HS-IT101 works better than chemotherapy for people with advanced melanoma that has stopped responding to standard treatments. HS-IT101 uses a patient's own immune cells, grown in large numbers in a lab, to fight …

This phase 3 trial tests an injection called ADSTEM for adults with moderate-to-severe atopic dermatitis (eczema) that hasn't responded well to standard treatments. About 286 people aged 19 to 70 will receive either the study drug or a placebo. The main goal is to see if the inje…

This study tests an injection called JYB1904 in 180 adults with chronic spontaneous urticaria (hives and itching lasting over 6 weeks) that isn't well controlled by standard antihistamines. Participants receive either the drug or a placebo every 12 weeks for 48 weeks. The main go…

This study compares two oral medications—tofacitinib and methotrexate—for treating severe alopecia areata, an autoimmune condition causing hair loss. 78 adults aged 18-60 with severe scalp or total body hair loss will take one of the drugs for 12 weeks. The main goal is to see wh…

This study tests a new shampoo for head lice. It aims to kill lice quickly and safely. The study will include 180 healthy people aged 2 and older with mild to moderate lice. The new shampoo will be compared to a similar product already on the market.

This early-stage trial will test whether a cream containing ivermectin (a drug used for parasites) can treat common skin warts. It will compare ivermectin alone, ivermectin combined with microneedling (tiny needles to help the cream absorb), and a standard salicylic acid treatmen…

This study tests two drugs together—pucotenlimab and becotatug vedotin—for people with advanced cutaneous squamous cell carcinoma that cannot be removed by surgery. The goal is to see if the combination shrinks tumors better than current treatments. About 38 participants will rec…

This study tests two prescription gels—metronidazole and clindamycin—to see which works better for moderate acne. Sixty adults aged 18 to 35 will apply the gel twice daily for 12 weeks. Doctors will check acne severity at the start and at weeks 4, 8, and 12 to measure improvement…

This early-phase trial tests whether adding a dietary supplement called LC-K76 to standard hormone therapy is safe for men with metastatic hormone-sensitive prostate cancer. Forty men will receive the supplement plus hormone therapy for 24 weeks, then be followed for another 24 w…

This study tests whether high intensity focused ultrasound (HIFU) works as well as standard cryotherapy (freezing) for treating low-risk basal cell carcinomas and Bowen's disease. About 294 adults with small skin cancers on their body (not face or hands) will be randomly assigned…

This early-phase trial will test different ways of using permethrin cream to treat scabies in 68 infants and children aged 1 month to 4 years. The goal is to see which strategy works best to kill the mites and relieve itching. Researchers will check skin scrapings under a microsc…

This early-phase trial tests whether low doses of erlotinib, a drug originally used for cancer, can improve symptoms of rare genetic skin conditions called keratinopathies. About 44 adults with confirmed diagnoses will take increasing doses over 24 weeks. The goal is to see if it…

This phase 3 trial compares a new injectable drug, GS101, to the established treatment Dupixent for adults with moderate-to-severe atopic dermatitis (eczema). About 572 participants will receive either GS101 or Dupixent every other week for a year. The main goal is to see if GS10…

This Phase 2 trial tests a new gel (AP4500) containing the antifungal drug terbinafine for mild to moderate toenail fungus. About 200 adults will apply the gel once or twice daily for 48 weeks. Researchers will compare it to a placebo and an existing treatment (Jublia) to see if …

This study compares two treatments for generalized vitiligo: PUVA therapy (a light-based treatment) and the pill Tofacitinib. Researchers will enroll 64 adults with stable vitiligo covering more than 10% of their body. The goal is to see which treatment works better and is safer …

This phase 4 trial tests whether adding recaticimab to vunakizumab works better than vunakizumab alone for adults with moderate-to-severe plaque psoriasis and high cholesterol. Forty participants will be randomly assigned to receive either the drug combo or vunakizumab plus a pla…

This early-phase study tests a new mRNA therapy that targets CD19, a protein on immune cells, to treat autoimmune diseases like lupus and immune anemia. The treatment uses lipid nanoparticles to deliver mRNA that helps the body clear harmful B cells. About 47 participants aged 14…

This study tests whether surgically removing the central mole (halo nevus) in people with vitiligo leads to better skin color restoration than using medication alone. Sixty participants aged 6 to 45 will be randomly assigned to either have the mole removed plus standard treatment…

This study compares two surgical techniques—Duhamel and Soave—for treating total colonic Hirschsprung disease, a severe birth defect where nerve cells are missing from the colon. Fifty children who had a first surgery as newborns will receive one of the two procedures. Researcher…

This study tests a combination of two experimental drugs (iparomlimab and tuvoraleimab) plus standard chemotherapy for people with advanced acral or mucosal melanoma, rare and aggressive skin cancers. About 48 adults who have had little or no prior treatment will receive the ther…

This phase 2 trial tests an injection called SHR-1139 in 10 adults with ulcerative pyoderma gangrenosum, a rare skin condition that causes painful, open sores. The main goal is to see if the drug can completely close the target ulcer within 12 weeks. Researchers will also check f…

This study compares two treatments for pityriasis versicolor, a fungal skin infection that causes discolored patches. One group will apply a clotrimazole cream twice daily for two weeks, while the other takes itraconazole pills daily for five days. The trial aims to see which app…

This study tests whether Coenzyme I injections can reverse vascular aging in 60 adults aged 40-70 with stiff arteries. Participants receive either the coenzyme or a placebo, and researchers measure changes in blood vessel function and stiffness over 28 days. The goal is to see if…

This study tests a treatment called Tropocells Autologous PRF, made from a patient's own blood, for chronic wounds that won't heal. About 16 adults with non-healing wounds will receive this gel plus standard care. The goal is to see if it safely helps wounds close completely.

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This Phase 3 trial tests an oral drug called KP-001 in 150 people aged 2 and older with venous malformations, lymphatic malformations, or KTS/CLOVES syndrome. Participants receive either KP-001 or a placebo for 24 weeks, then everyone gets the drug for another 28 weeks. The goal …

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study tests whether a patch made from donated human placenta tissue, plus standard wound care, helps close nonhealing venous leg ulcers better than standard care alone. About 70 adults with ulcers present for at least 4 weeks will take part. Those who get standard care first…

This study will test the drug ivarmacitinib in 1,000 people aged 12 to 75 with moderate-to-severe atopic dermatitis (eczema). Participants take a daily pill for up to 52 weeks, with the option to adjust the dose. Researchers will measure how well the drug clears skin rashes and r…

This study compares injecting secukinumab directly into skin lesions versus standard under-the-skin injections for people with localized hidradenitis suppurativa (HS). The goal is to see if local delivery works better and causes fewer side effects. Thirty adults with HS lesions i…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central venous and arterial blood) can accurately diagnose low cardiac output in patients with septic shock from severe skin infections. About 74 adults will be monitored during hyperbar…

This study tests whether an AI-powered imaging tool can accurately detect the edges of common skin cancers before surgery. Researchers will compare AI-OCT scans with standard surgical results in 30 adults with basal cell carcinoma. If the AI works well, it could help surgeons rem…

This phase 3 trial tests whether a magnetic tracer (Magtrace) works as well as the standard radioactive dye plus blue dye for finding sentinel lymph nodes in people with melanoma. About 254 adults having surgery for melanoma will receive both tracers and be randomly assigned to h…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study tests whether a special camera (LC-OCT) can help surgeons remove basal cell carcinoma more efficiently. About 290 adults with skin cancer will be randomly assigned to standard surgery or surgery guided by this imaging tool. The goal is to see if the camera reduces the …

This study compares several non-invasive methods to measure foot calluses (plantar hyperkeratosis) in 50 people, half with diabetes and half without. The goal is to find the most reliable technique for assessing callus hardness and stiffness, which could help prevent foot ulcers …

This study will test whether artificial intelligence can help diagnose oral lesions that might turn into cancer. Researchers will use photos of the lesions and cell samples from the mouth, along with a special blue stain, to train an AI model. The goal is to see if the AI can mat…

This phase 3 trial tests whether adding daily calcitonin injections to standard shingles treatment can prevent postherpetic neuralgia, a painful nerve condition that can last for months or years. Researchers will enroll 168 adults aged 50 and older who have had a shingles rash fo…

This study tests whether two skin treatments—microneedling and a chemical peel—can reduce the number of precancerous spots and skin cancers in older veterans. About 96 veterans aged 60 and older with fair skin and multiple precancerous spots will receive one treatment on one arm,…

This study tests whether a silicone foam dressing placed over the breathing tube, along with regularly moving the tube, can prevent pressure injuries inside the mouth. It will involve 75 adults in intensive care who need a breathing machine. The goal is to find a simple way to pr…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This Phase 3 trial tests whether a daily imiquimod cream applied to the face for 12 weeks can prevent new basal cell carcinomas (BCC) in 1,630 veterans at high risk. Participants apply either the active cream or a placebo and are followed for up to 3 years with skin exams. The go…

This study tests whether a gel made from aloe vera and peppermint can prevent pressure injuries (bedsores) in intensive care unit (ICU) patients. Forty adults who are at risk for bedsores will be randomly assigned to receive either the natural gel or standard hospital care. The m…

This study tests whether a 30-minute online class and monthly reminders can help ultrarunners use more sunscreen and protective clothing. 110 runners in the 2026 Western States Endurance Run will be randomly assigned to the class or a general wellness brochure. Researchers will m…

This study tests whether an ultrasound-based risk score can better predict and prevent pressure injuries (bedsores) in critically ill ICU patients. In phase 1, researchers will check how accurately the score identifies high-risk patients. In phase 2, some patients will receive nu…

This study tests a new shingles vaccine in 135 healthy adults aged 50 and older. Researchers will compare the immune response and safety of the new vaccine against an existing one to find the best dose. The goal is to prevent shingles, a painful rash caused by the chickenpox viru…

This study tests a gel called TAR-0520 to see if it can prevent hand-foot syndrome, a painful skin reaction caused by the chemotherapy drug capecitabine. About 25 people with breast or colorectal cancer will apply the gel to their hands twice daily for 12 weeks. Their feet will n…

This study tests whether an extra dose of the shingles vaccine (Shingrix) can boost immunity in people who have had a solid-organ transplant, like a kidney or liver. About 30% of transplant patients still get shingles after the standard two-dose vaccine, likely due to immune-supp…

This study tests whether a gel containing polyhexanide and biguanide can prevent biofilm (a tough layer of bacteria) from forming in pressure ulcers (bedsores). About 140 adults over 65 with stage II or III bedsores will receive the gel alone or with a special dressing. The goal …

This study tests whether a genetic test can prevent rare but severe skin reactions caused by the common gout drug allopurinol. About 228 Vietnamese adults with gout will either get the test before treatment or receive standard care. Those with a high-risk gene will take a differe…

This study tests whether leaving the white, creamy coating (vernix caseosa) on a newborn's skin for at least 24 hours after birth can prevent eczema (atopic dermatitis) during the first year of life. Over 1,300 mother-infant pairs in Chile will be randomly assigned to either keep…

This study will look at 250 people who received the CYFENDUS anthrax vaccine after being exposed to anthrax bacteria during a mass event. Researchers want to see if the vaccine, given along with antibiotics, can prevent inhalational anthrax and anthrax meningitis. The study is ob…

This study tested whether taking a cistanche supplement for 8 weeks, along with a supervised training program, improves anaerobic exercise performance and recovery in young men. 56 men aged 18-25, either elite or amateur athletes, were randomly assigned to receive cistanche extra…

This early-phase trial tests a new drug called TLL-018 in 36 adults with moderate-to-severe chronic spontaneous urticaria (hives) that standard antihistamines can't control. The goal is to see how quickly TLL-018 reduces itching and hives after the first dose. Participants will r…

This study tests a small, portable device called SNaP that uses gentle suction to help surgical wounds on the lower legs heal faster after Mohs surgery for skin cancer. About 60 adults aged 19-79 with lower leg wounds will either use the SNaP device or receive standard wound care…

This study tests a new barrier cream (Dermategrity "Anti-fecal" Barrier Cream) that contains zinc oxide and a natural plant extract to protect and heal skin damaged by incontinence. Sixty adults with incontinence-associated dermatitis will receive either the new cream or a standa…

This virtual clinical trial will test whether GenLabs' Social Skin products—a cleanser, serum, and cream—can improve acne symptoms and help skin heal better than a placebo. About 150 healthy adults aged 18 to 65 with acne will use the products for 30 days. The main goal is to see…

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study tests whether an artificial intelligence-powered digital education program can reduce the severity of radiodermatitis (skin irritation from radiation) and improve quality of life in women with breast cancer. 38 patients will be randomly assigned to either receive the A…

This phase 2 trial tests a medicated foam called roflumilast on skin rashes caused by checkpoint inhibitor cancer drugs. Twenty adults with mild to severe rash will apply the foam daily for 16 weeks. The goal is to see if it safely reduces rash severity and improves quality of li…

This study looks at whether lowering salt in your diet can make eczema less severe. Forty adults with eczema will eat a low-salt diet for 24 weeks. For 5 weeks they'll take salt pills, and for another 5 weeks they'll take placebo pills, to see the real effect of sodium. Researche…

This study tests whether adding a pill called pentoxifylline to standard skin creams can improve mild-to-moderate psoriasis. About 140 adults will take either the study drug or a placebo twice daily for 12 weeks. Researchers will measure changes in skin severity, itch, and qualit…

This study tests whether isotretinoin or doxycycline works better for treating an acne-like rash that can appear in people taking certain cancer drugs. About 50 participants who already have a moderate to severe rash will receive one of the two medications. The goal is to see whi…

This study tests a new 'smart bandage' that checks wound moisture, temperature, and acidity, then sends updates to a nurse's app. About 110 adults with hard-to-heal leg ulcers will either get the smart bandage plus standard care or standard care alone. The goal is to see if the s…

This early-phase trial tests whether a home-based morning light therapy program can help people with advanced melanoma who are receiving tumor-infiltrating lymphocyte (TIL) therapy. The light therapy is delivered through an iPad app and aims to improve the body's natural sleep-wa…

This Phase 2 study tests lebrikizumab (Ebglyss) in 15 adults with moderate-to-severe prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants receive injections every two weeks for 24 weeks. The main goals are to measure how much itching decreases …

This Phase 1 trial will test the safety and tolerability of multiple doses of PG-033 tablets in 30 healthy adults. Participants will be randomly assigned to receive either PG-033 or a placebo. The study aims to find out how the drug moves through the body and whether it causes an…

This Phase 2 trial tests whether the experimental drug HRS-3095 can reduce itching and wheals in adults with chronic spontaneous urticaria (hives) that isn't well controlled by antihistamines. About 190 participants will receive either the drug or a placebo daily for 4 weeks. The…

This study tests whether adding oral iron supplements to standard eczema treatment can reduce skin symptoms and improve quality of life in adolescents aged 12 to 16 with mild to moderate atopic dermatitis. Researchers will also check if iron levels in the blood affect how well th…

This study tests whether Changji'an capsules, a traditional Chinese medicine, can reduce diarrhea and stomach pain in people with irritable bowel syndrome (IBS) where diarrhea is the main symptom. About 636 adults aged 18 to 65 will take the capsule or a placebo for 8 weeks. The …

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study compares three lying positions (on your back, side, or stomach) before a routine injection into the buttock muscle. Researchers will measure pain, comfort, and satisfaction in 111 adults. The goal is to find the best position to make injections less uncomfortable.

This pilot study will test whether a device that gently stimulates a nerve in the ear (taVNS) can reduce facial redness and flushing in people with rosacea. Ten adults with moderate-to-severe rosacea will use the device daily for 4 weeks, then be followed for another 4 weeks to s…

This study tests a gel called VC005 on adults with mild to moderate atopic dermatitis (eczema). About 120 participants will use either the gel or a placebo to see if it safely reduces skin redness, itching, and rash. The goal is to ease symptoms, not cure the condition.

This study tests whether using a fractionated CO₂ laser on wound edges during Mohs skin cancer surgery can improve scar appearance. Fifty adults having Mohs surgery will have half their wound treated with the laser and the other half left untreated. Researchers will compare scar …

This study tests whether a topical eye drop called timolol can help surgical wounds on the scalp heal faster and look better after Mohs surgery. About 40 adults will either use timolol or standard wound care. Researchers will check healing and scar appearance at 4, 8, and 12 week…

This pilot study will test whether taking a high dose of oral hyaluronan (HA35) daily for 40 days can reduce facial fullness, double chin, skin redness, and improve skin vitality and body weight. Thirty adults seeking non-invasive aesthetic improvement will participate. The study…

This study will test whether methotrexate or apremilast works better at reducing itching and improving daily life in 80 adults with psoriasis. Participants will take one of the two oral medications for 8 weeks. The main goal is to see which drug provides more relief from the itch…

This study looks at two ways to care for wounds after Mohs surgery for skin cancer: using a skin substitute or letting the wound heal naturally. About 50 adults will take part to see which method leads to better-looking scars and faster healing. The goal is to find the best optio…

This early-phase trial tests a probiotic capsule containing five bacterial strains to treat moderate to severe acne in 34 adults aged 18 to 45. The idea is that improving gut health and reducing inflammation may calm acne breakouts. Researchers will also track blood sugar spikes …

This study tests a gel made from hyaluronan (HA35) to see if it can quickly relieve moderate-to-severe itching from conditions like eczema, insect bites, and hives. About 30 adults will apply the gel once, and researchers will check itch levels at several time points up to 24 hou…

This study tests whether adding ear acupressure (using tiny seed patches on specific ear points) to a standard antihistamine (Loratadine) can better reduce hives symptoms and improve quality of life compared to a sham ear treatment. Sixty-six adults with Wind-Heat type urticaria …

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study looks at whether adding a bacterial lysate (OM-85) to standard antihistamines can better control chronic spontaneous urticaria (CSU), also known as chronic hives. Researchers will observe 132 adults who have not responded well to antihistamines alone. The main goal is …

This small pilot study will test a new type of light therapy for moderate-to-severe acne. A special gel is applied to the face, then activated with red light to kill bacteria and reduce inflammation. Ten people aged 16 and older will receive treatments twice a week. The goal is t…

This study tests whether Xdemvy eye drops can reduce eyelash mite irritation and improve comfort for people who wear special scleral lenses. Five adult lens users with moderate to severe Demodex blepharitis will use the drops and report changes in symptoms like dryness, itching, …

This study tests a cream called roflumilast 0.15% for itching in people with mild to moderate atopic dermatitis (eczema). About 40 participants aged 12 and older will apply the cream once daily for 4 weeks. Researchers will track how patients describe their itch and other skin se…

This study tests whether daily soaks with normal saline (salt water) can reduce severe skin reactions caused by radiation therapy. About 150 adults with head and neck cancer or sarcoma will either get standard care or standard care plus a 5-10 minute saline soak each day. Researc…

This study will see if adding a cold plasma device to standard scar care helps improve scars like keloids, burn scars, and acne scars. About 800 people will take part, with half getting standard care plus plasma and half standard care alone. Researchers will track changes in scar…

This study tests whether alexandrite laser works as well as Nd:YAG laser for treating hidradenitis suppurativa (HS), a painful skin condition. Twenty-one people will receive both lasers on different sides of their body to compare results. The goal is to see if alexandrite can red…

This early-stage study tests a new drug called HXN5003 in 28 healthy adults to see if it is safe and how the body processes it. The drug is being developed for atopic dermatitis (eczema). Participants receive either the drug or a placebo, and researchers monitor for side effects …

This early-stage trial is testing an experimental drug called IBI3033 in 16 adults with moderate-to-severe atopic dermatitis (eczema). The main goal is to check if the drug is safe and how the body processes it. Participants will receive either IBI3033 or a placebo injection over…

This study tests whether the experimental drug LAD328 can reduce symptoms of hidradenitis suppurativa, a chronic skin condition causing painful lumps. About 50 adults with moderate-to-severe disease will receive either LAD328 or a placebo. The main goal is to see if the drug lead…

This study tests two injection treatments for common warts: one using a patient's own blood components (platelet-rich fibrin) and the other using vitamin D. About 70 adults with warts will receive one of the two injections. The goal is to see which treatment shrinks warts more an…

This study tests a new medicine called MG-K10 for people with chronic hives (itchy welts) that don't get better with standard allergy pills. About 226 teens and adults will receive either the drug or a placebo injection every few weeks. The goal is to see if MG-K10 reduces itchin…

This study tests two medical creams containing urea (20% and 40%) on people with mild plaque psoriasis or non-pustular palmoplantar psoriasis. Each participant applies the cream to one affected area and leaves a similar area untreated for comparison. The goal is to see if the cre…

This study tests a cream called PROXERA PSOMED 30, which contains 30% urea, for treating nail psoriasis. 21 adults with nail psoriasis will apply the cream to one nail and Vaseline to another nail twice daily for 24 weeks. Researchers will compare how much each nail improves usin…

This study tests whether taking oral probiotics for 12 weeks can reduce acne lesions and lower inflammation in people with moderate acne. Researchers will compare probiotics to a placebo in 64 Pakistani participants aged 15-35. The goal is to find a safe, antibiotic-free way to m…

This study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…

This study tests whether a special gel containing carbon dioxide (carboxytherapy paste) can reduce redness and swelling after microneedling, a cosmetic procedure for facial aging. Twenty adults will receive the gel on one side of their face and a placebo on the other, then be mon…

This study compares three types of CPAP masks (binasal prong, nasal cannula, and nasal mask) to see which causes fewer nasal pressure injuries in preterm infants. 75 babies in the NICU will be randomly assigned to one mask type and monitored for 4 days. The goal is to find the ge…

This study tests whether a special dermocosmetic cream can reduce facial redness and visible blood vessels in people with a common type of rosacea. Fifty adults will apply the cream to one side of their face and a placebo to the other, twice daily for two months, then continue wh…

This study tests whether a cream made from metformin, a common diabetes drug, can safely improve mild psoriasis. About 55 adults will apply either the metformin cream or a placebo twice daily for two months. Researchers will check skin biopsies and symptom scores to see if the tr…

This study compares two treatments for keloids (raised scars that grow beyond the original wound). One group gets a special freezing treatment inside the scar (intralesional cryosurgery) alone. The other group gets the same freezing plus an injection of two medicines (5-fluoroura…

This study tests whether a plaster containing uracil can reduce symptoms of hand-foot syndrome (HFS) in adults undergoing chemotherapy. HFS causes redness, swelling, and pain on the hands and feet. Researchers will compare the uracil plaster to a standard soothing cream. About 80…

This study tests whether a probiotic called Lactiplantibacillus plantarum Dad-13, originally from buffalo milk curd, can improve gut health and physical performance in 30 adolescent athletes. Participants will take the probiotic and have their gut bacteria, inflammation markers, …

This phase 2 trial tests whether verteporfin, a drug injected into the skin during tummy tuck surgery, can reduce scar formation. Twelve adults will receive different doses of verteporfin and a placebo in separate parts of their surgical wound. Researchers will compare scar appea…

This Phase 3 study tests the safety of SD-101 cream (6% allantoin) in 80 people with epidermolysis bullosa, a condition that causes fragile, blistering skin. Participants must have completed a prior study (SD-007). The main goal is to track any side effects over time.

This Phase 2 trial tests a daily nail lacquer containing 2% tofacitinib for nail psoriasis. Ten adults with nail psoriasis will apply the lacquer at home for 26 weeks. Researchers will measure changes in nail appearance using the Nail Psoriasis Severity Index and quality of life …

This study tests a new topical gel containing 5% spironolactone against a standard 0.1% adapalene gel for treating acne. Forty people with mild to moderate acne will apply each gel to opposite sides of their face, allowing direct comparison. The goal is to see if the spironolacto…

This study tests whether daily red light therapy can prevent or reduce skin and mouth side effects in children aged 0-16 receiving radiation for cancer. About 248 kids will get a daily LED light treatment on the radiated area. Researchers will compare their side effects to those …

This study looks at whether using ketoconazole 2% shampoo for seven days works better than using it for three days to treat pityriasis versicolor, a common fungal skin condition that causes discolored patches. About 76 people aged 12 and older with confirmed infection will be ran…

This study tests a special care plan to help Chinese patients with advanced EGFR-mutated lung cancer who are taking the drug amivantamab. The plan focuses on preventing common side effects like blood clots, skin rashes, and infusion reactions. About 122 adults will join to see if…

This study will test the safety of a new biologic drug called stapokibart, given as a shot, in 400 adults with seasonal allergic rhinitis (SAR). Participants are already prescribed the drug by their doctor. The main goal is to track any side effects. This is an open-label study, …

This study tests whether an oral collagen supplement (Collagendep) can reduce vulvar dryness in 40 women with genital lichen sclerosus who are also receiving fat grafting. Participants take the supplement daily for 4 months. The main goal is to see if dryness improves, with secon…

This study tests whether playing a person's favorite music before and during wound care can reduce pain and help pressure injuries (bed sores) heal faster. Researchers will compare wound care with music to standard care without music in 50 older adults living in long-term care ho…

This study compares Vashe solution, a wound cleanser, to standard saline for treating leg ulcers that show signs of heavy bacterial infection. About 102 adults with venous or mixed leg ulcers will be randomly assigned to one of the two solutions. The goal is to see if Vashe reduc…

This study tests whether a medicated cream called crisaborole works better than a placebo cream for people with mild to moderate eczema. About 270 people aged 12 to 50 will apply the cream twice daily for four weeks. The goal is to see if the cream can clear or nearly clear the e…

This study tests whether adding MELA B3 serum to a 35% glycolic acid peel works better than the peel alone for treating dark spots (melasma, post-acne marks, age spots) and signs of aging. About 80 adults aged 30-70 in Buenos Aires will use the treatments for 3 months. The goal i…

This phase II trial tests whether giving preventive medications (loperamide for diarrhea and cetirizine for rash) can reduce common side effects of the cancer drug capivasertib when combined with fulvestrant. About 108 adults with HR+/HER2- metastatic breast cancer will participa…

This study tests whether a small, watch-sized device that delivers mild electrical stimulation to the skin can improve symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Researchers will compare the real device to a sham (fake) version in 200 adults ag…

This study will test whether a gel containing dutasteride, a drug usually used for hair loss, can treat facial acne. Fifty adults with acne will apply the dutasteride gel to one side of their face and either a placebo or a standard triple-combination acne gel to the other side. R…

This study looks at whether a natural compound from licorice root, called glycyrrhetinic acid, can help calm irritated skin and repair the skin barrier. Researchers will apply a mild irritant to the skin of 30 healthy adults, then treat the area with a cream containing the compou…

This study tests whether a single 23-30 minute session of specially designed music or pink noise can reduce anxiety in adults with psoriasis. About 120 participants will listen at home using headphones. The goal is to see if audio therapy offers a quick, accessible way to manage …

This study looks at whether losing weight can make psoriasis treatments more effective in overweight or obese patients. About 70 adults with moderate-to-severe plaque psoriasis will either get standard care alone or standard care plus a personalized weight loss plan (diet, exerci…

This study tests whether a traditional Chinese herbal formula called Qibei Jiedu can prevent or ease the painful skin rash (radiation dermatitis) that often occurs during breast cancer radiotherapy. Sixty women with early-stage breast cancer will receive either the herbal drink o…

This study tests whether a traditional Chinese medicine hand-foot soak can reduce nerve pain and skin reactions caused by chemotherapy. About 300 adults with solid tumors who have these side effects will use the soak. The goal is to see if it improves symptoms and quality of life…

This phase 3 study tests an oral tablet called LW402 in 480 adults with moderate-to-severe atopic dermatitis (eczema). Participants will take either the drug or a placebo daily for 16 weeks. The goal is to see if LW402 can significantly improve eczema severity and skin clearance …

This study tests a new wound therapy system called ConvaVAC™ Ag+ in 87 people with chronic venous leg ulcers. The device uses negative pressure and silver to clean and help heal wounds that won't close on their own. Researchers will check if it safely reduces wound size after 14 …

This study compares two prescription ointments, crisaborole and tacrolimus, for treating mild to moderate eczema (atopic dermatitis) in people aged 5 to 25. Researchers will measure how much the skin improves after treatment with each ointment. The goal is to find out which one w…

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This pilot study tests whether giving dexamethasone (a steroid) to children hospitalized with orbital cellulitis (a serious eye infection) is worth studying further. Thirty children will receive either dexamethasone or a placebo by IV. The main goal is to see if a larger trial is…

This study compares a new emollient balm made from seawater (Relipid+) to a leading balm (Lipikar) for mild to moderate eczema in people aged 6 months to 70 years. The goal is to see if the new balm works just as well at reducing symptoms and improving skin health. Researchers wi…

This study tests whether adding platelet-rich plasma (PRP) to microneedling improves itching and dark patches in macular amyloidosis better than microneedling alone. Thirty adults with the condition will have each side of their face treated differently, and results will be checke…

This study tests if a cream made from diacerein can safely reduce psoriasis symptoms like redness and scaling. About 60 adults with mild psoriasis will apply the cream or a placebo twice a day for two months. Doctors will check their skin at several visits to see if the cream lea…

This study compares two skin-protective strategies—a fragrance-free emollient plus foam dressing versus a silicone-based barrier film—in 104 head and neck cancer patients receiving TomoTherapy. The goal is to see which approach better prevents or reduces painful radiation dermati…

This study tests an experimental capsule called QLS12010 in 160 adults with moderate-to-severe atopic dermatitis (eczema). The goal is to see if it reduces skin redness, itching, and rash better than a placebo over 16 weeks. Participants must have had eczema for at least one year…

This study tests a new cream called KR230109 for mild to moderate acne. About 180 people aged 18 to 40 will use the cream or a placebo for 12 weeks. The goal is to see if the cream safely reduces pimples and skin bumps better than no treatment.

This study tests whether a mouthwash containing sodium hyaluronate and Sh-Oligopeptide-85 can reduce pain and sores in people with oral lichen planus, a chronic inflammatory condition. Forty adults with painful mouth lesions will use either the test mouthwash or a standard cortic…

This study tests a cosmetic cream made with postbiotics (natural bacteria extracts) to see if it safely reduces wrinkles and age spots. About 45 women aged 35-60 with mild to moderate skin aging will apply the cream twice daily for 3 months. Researchers will measure changes in sk…

This study tests whether dexamethasone palmitate, a steroid, can better relieve shingles pain and prevent long-term nerve pain compared to standard care. About 954 adults with shingles rash and severe pain will receive the drug by injection or infusion. Researchers will track pai…

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks.…

This study tests whether taking a daily saffron extract capsule can improve skin health by reducing wrinkles, fine lines, and dark spots. Fifty healthy adults aged 30 to 55 will take either the saffron supplement or a placebo for a set period. Researchers will use special skin sc…

This study compares two ways of cleaning chronic skin wounds: using a surgical microscope versus just the naked eye. About 98 adults with wounds from diabetes, pressure, or injury will be randomly assigned to one method. Researchers will measure wound healing, pain, and drainage …

This study tests whether adding URGO FilmoCream Eczema to standard steroid cream works better than steroid cream alone for treating atopic dermatitis. Researchers will compare two similar eczema lesions on each of 44 adults—one treated with steroids only, the other with steroids …

This study will test a special laser called the Vbeam Pro on 40 adults with rosacea or port-wine stain birthmarks. The goal is to see if the laser can safely clear or improve these red skin conditions. Participants will receive laser treatments and be evaluated for changes in app…

This study looks at whether applying moisturizer while still in the shower or bath is better than applying it after towel drying for teens with eczema. Thirty participants aged 12-18 will try each method for one month and report which they prefer. Researchers will also measure sk…

This study tests a new system called Tight Alright that uses a small wearable device under bandages to measure pressure on leg ulcers. The device sends real-time pressure data to a mobile app and healthcare team, helping ensure the right pressure is applied for healing. About 40 …

This study tests whether a cream containing both testosterone and estrogen works better than estrogen alone to reduce pain during sex for women with vulvodynia. About 44 adult women with moderate to severe pain will use one of the two creams daily. The goal is to find a more effe…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study tests whether letting patients report their symptoms online can help doctors schedule follow-up visits only when needed. About 250 adults with chronic skin conditions like eczema or psoriasis will either get standard fixed appointments or flexible scheduling based on m…

This study will collect information from medical records and routine clinic visits of 100 people in Egypt with hereditary angioedema (HAE) type I or II. The goal is to understand how the condition is diagnosed and managed in current medical practice. No new treatments are being t…

This study tests a paper-based decision aid designed to help people with intermediate-risk melanoma decide whether to have a sentinel lymph node biopsy. The tool provides clear information about the procedure, its risks and benefits, and helps patients think about their personal …

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study looks at how muscle tiredness changes the way female volleyball players move their legs when landing on one foot. Researchers will use smartphone videos to measure hip, knee, and ankle motion in 35 athletes. The goal is to understand injury risks better, not to test a …

This study aims to create stem cell lines from blood samples of 16 people: 4 with severe scleroderma, 4 with mild scleroderma, and 8 of their healthy relatives. These stem cells will be turned into various tissue types (like heart, skin, and immune cells) in the lab to study how …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study will test if blocking a protein called TL1A can reverse skin scarring in systemic sclerosis, a rare autoimmune disease. Researchers will take blood and skin samples from 10 patients with early diffuse scleroderma and 10 healthy people. They will treat the samples in th…

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …

This study looks at whether changing how much salt you eat can affect skin sodium levels and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either sodium tablets or a placebo for several weeks. The goal is to see if this approach is practic…

This study looks at whether using genetic markers from a child's skin tumor can help doctors decide how much surgery is needed. About 51 children and young adults up to age 25 with localized melanoma or similar growths will have their tumor tissue reviewed centrally. Based on ris…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study tests a tiny microdevice, about the size of a grain of rice, that holds up to 20 different FDA-approved skin medications. Placed directly on the skin, it releases very small amounts of each drug to see how the skin reacts. The goal is to find out if this device can saf…

This study will test an artificial intelligence system that analyzes smartphone photos of hard-to-heal wounds to see if they are getting better, staying the same, or getting worse. Researchers will enroll 1,000 people with wounds that have not healed for over a month. The goal is…

This study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This early-stage study looks at how a drug called Flonoltinib maleate (being developed for a bone marrow condition) is processed and removed from the body. Six healthy adult men will take a single dose, and researchers will measure the drug and its breakdown products in blood, ur…

This study follows 34 adults with moderate-to-severe hidradenitis suppurativa (HS) who are taking secukinumab as part of their routine care. Researchers will use a special CT scan to check if the drug affects the buildup of plaque in the heart arteries over 12 months. The goal is…

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study aims to create a new questionnaire that measures how well nurses can prevent pressure injuries (also known as bedsores). Pressure injuries are a common problem in hospitals that can cause pain and longer stays. Researchers will test the questionnaire with 300 nurses in…

This early-phase trial will test the safety and tolerability of a single injection of BW-41012 in 40 healthy adults aged 18 to 65. Participants will be randomly assigned to receive either the drug or a placebo, and researchers will monitor for side effects and measure how the dru…

This study looks at how often people develop allergic skin reactions to two different wound dressings used after open shoulder surgery: one made from silk protein and another from a medical glue mesh. About 350 adults having shoulder surgery will be randomly assigned to one dress…

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…

This study looks at how different positions and positioning devices affect pressure on areas like the heels, tailbone, elbows, and back of the head in burn patients. Researchers will use a special pressure-sensing mat to find which setups create the least pressure. The goal is to…

This study looks at how the skin barrier changes in intensive care patients who are at risk for pressure injuries (bedsores). Researchers will use non-invasive biosensors to measure things like skin moisture, acidity, and temperature in areas prone to bedsores. The goal is to und…

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study tests a new imaging technique called full-field OCT to see if it can spot muscle inflammation faster than the usual method, which takes weeks. Researchers will compare both methods on muscle samples from 20 healthy adults and people with suspected myositis. The goal is…

This study explores whether short, AI-generated videos from a virtual doctor can help people with psoriasis stick to their topical medication routine. Fifteen adults will be split into three groups: weekly AI videos, weekly human doctor videos, or standard care (one follow-up vis…

This study looks at whether the placement of hand sanitizer in a doctor's office affects how much psoriasis patients trust their doctor and feel stigmatized. Researchers will observe doctors' hand hygiene habits and ask 250 patients to fill out questionnaires. The goal is to find…

This study looks at how two common psoriasis drugs, cyclosporine and methotrexate, affect a protein called IL-33 in the blood. Researchers will measure IL-33 levels and track psoriasis severity in 118 adults with moderate to severe psoriasis. The goal is to understand how these d…

This study is testing a new, non-invasive way to collect and analyze skin oil (sebum) using a simple adhesive patch called Sebutape. Researchers will recruit 200 people, including healthy volunteers and patients with acne, eczema, psoriasis, or seborrheic dermatitis. The goal is …

This study looks at how body composition (like fat and muscle) and metabolism (how the body uses energy) are connected in adult and older Filipino athletes. Researchers will measure things like body fat, muscle mass, resting energy use, and fitness levels in 120 athletes and non-…

This early-stage study tests a single dose of an experimental drug called BW-20805-2 in 24 healthy adults aged 18 to 60. The main goal is to check for side effects and see how the drug moves through the body. Participants receive one injection under the skin and are monitored for…

This study looks back at the medical records of 350 adults diagnosed with cutaneous T-cell lymphoma, a rare type of skin cancer, treated at Hospital México in Costa Rica between 2019 and 2025. Researchers aim to describe the patients' backgrounds, the treatments they received, an…

This study looks at whether operating room nurses who know more about pressure injuries caused by medical devices make better decisions in the operating room. About 165 nurses from three hospitals in Turkey will take a knowledge test and answer questions based on real-life scenar…

This study tests whether using a smartphone app to monitor chronic wounds at home can reduce the number of in-person doctor visits. One hundred adults with a single chronic wound (like a diabetic foot ulcer or pressure sore) will be split into two groups: one using the app with a…

This study will follow 50 Costa Rican patients with moderate-to-severe atopic dermatitis (eczema) who are receiving advanced treatments like dupilumab or JAK inhibitors as part of their regular care. Researchers will collect information on patient characteristics, treatment patte…

This study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how many also have conditions like obesity, diabetes, high blood pressure, heart disease, or psoriatic arthritis. Researchers want to understand how these problems relate to psoriasi…

This study will review medical records of 300 children under 18 with psoriasis in Costa Rica. Researchers want to learn about the children's symptoms, how severe the disease is, what other health problems they have, and what treatments they receive. No new treatments or tests are…

This study tests a non-invasive imaging technique called LC-OCT for diagnosing basal cell carcinoma, the most common skin cancer. Researchers will review medical records of about 300 patients to see if LC-OCT can accurately detect cancer and guide treatment without needing a biop…

This study aims to develop and test an AI system that uses smartphone photos with a color card to measure redness in psoriasis lesions. Fifty adults with psoriasis will take weekly photos at home and have clinic photos taken. The goal is to see if this simple, low-cost method mat…

This observational study will follow 45 adults with severe plaque psoriasis to see how standard treatment affects their skin, dermoscopic images, and quality of life. Participants will be evaluated at the start and again after 12 and 24 weeks of treatment. The goal is to better u…

This study looks at the blood immune cells of 10 adults with a rare inherited skin condition called NIPAL4 ichthyosis. Researchers want to understand why three patients with this skin disease also developed a very rare lymphoma (Sezary syndrome). By describing the normal immune c…

This observational registry will follow 50 patients with psoriasis or psoriatic arthritis who are receiving IL-23 inhibitors (guselkumab or risankizumab) as part of their routine care in Costa Rica. Researchers will track how well the drugs improve skin and joint symptoms and qua…

This study tests whether taking statins (a common cholesterol drug) can protect the heart and brain from the harmful effects of breathing bushfire smoke. Healthy adults aged 18-64 will be exposed to simulated smoke in a controlled setting, with some taking statins short-term (2 d…

This study creates a national registry for people with generalized pustular psoriasis (GPP) in Costa Rica. Researchers will collect information from about 50 patients to better understand the disease, how it progresses, and what treatments are used. The goal is to improve care fo…

This study looks at a new way to detect cancer cells in the portal vein blood of people with pancreatic cancer. The goal is to see if these cells can warn early if the cancer comes back or spreads. The study will involve 20 participants and uses a special ultrasound-guided proced…

This study will test a new device that uses a camera and machine learning to measure foot pressure and foot area. Researchers will compare it to the current standard pressure mat in 150 healthy adults. The goal is to see if the new tool is accurate and reliable enough for future …

This study looks at whether professional e-sports players are more physically fit than amateur players. Researchers will measure reaction time, endurance, and grip strength in 40 adults aged 18 to 30. The goal is to understand how different levels of gaming affect physical health…

This study will test whether a facial cream containing postbiotics (beneficial bacteria byproducts) can improve the skin microbiome and appearance in 45 women aged 40-60 with sensitive skin. Participants will use a placebo cream for 6 weeks, then the active cream for 8 weeks. Res…

This study looks at how the antibiotic delafloxacin spreads through the body in 20 adults with serious skin, soft tissue, bone, or joint infections. Researchers will measure drug levels in blood and in tissues collected during surgery. The goal is to understand if the drug reache…

This study will take high-resolution photos of the eyes of 950 people with psoriasis, eczema, or hives, plus healthy volunteers. Using artificial intelligence, researchers aim to find eye patterns linked to these skin conditions. The goal is to create a noninvasive tool for earli…

This study will look at 200 people aged 18 to 25 with mild, moderate, or severe acne, plus healthy volunteers, to understand how acne develops in Singapore's tropical climate. Researchers will analyze skin bacteria, immune responses, and use AI to grade acne from photos. The goal…

This study aims to find out whether some women diagnosed with polycystic ovary syndrome (PCOS) actually have a rare genetic condition causing severe insulin resistance. Researchers will compare 25 women with a known LMNA gene mutation (linked to lipodystrophy) to 50 women with cl…

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This study tests whether training intensive care nurses in evidence-based practices can lower rates of ventilator-associated pneumonia, pressure ulcers, and central line bloodstream infections. Researchers will train nurses and use advanced equipment, then compare infection rates…

This study aims to create a reliable, long-lasting itch model by combining heat with substances that cause itching, like histamine and cowhage. Researchers will measure how 28 healthy adults rate their itch and pain sensations, along with skin blood flow. The goal is to better un…

This study will test a new, gentle device that collects fluid from the skin of babies up to 6 months old. Researchers want to see if it's comfortable and can measure chemical signals that may explain why some babies get eczema. By comparing healthy babies and those with eczema, t…

This study tests whether training nurses to follow evidence-based guidelines can reduce infections and other complications in intensive care units (ICUs) in low- and middle-income countries. About 50 nurses will be trained and their patients' outcomes compared to usual care. The …

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This study looks at how certain immune cells, called MAIT cells, behave in people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will take skin and blood samples from 45 adults with HS and compare them to samples from people with other skin diseases. Th…

This study looks at whether a deep cleaning of the gums can improve symptoms in people with oral lichen planus, a chronic inflammatory condition affecting the mouth. Thirty participants will receive the cleaning and be monitored for changes in signs, symptoms, and immune cell lev…

This study looks back at 238 patients with a common skin cancer called squamous cell carcinoma. Researchers will compare special skin photos (dermoscopic images) with lab results from removed tumors. The goal is to see if certain features in the photos can tell how deep the cance…

This study looks at how caring for a child with mild to moderate eczema (atopic dermatitis) affects caregivers' work and family life. About 100 Canadian caregivers will answer questionnaires about missed work, reduced productivity, and family impact. The goal is to better underst…

This study looks at whether using a high-frequency ultrasound before surgery for common skin cancers on the head and neck can help surgeons remove the entire tumor the first time. About 400 adults with basal or squamous cell skin cancer will be in the study. Some will get the sta…

This study looks at whether tongue and facial images can help doctors understand psoriasis better. Researchers will collect photos and lab data from 450 people with and without psoriasis. The goal is to find patterns that link Traditional Chinese Medicine signs to blood tests and…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study will use a special headband that reads brain waves to see how adults with mild to moderate atopic dermatitis (eczema) respond to a single application of a marketed cream compared to plain water. Twenty participants will have their brain activity measured for signals re…

This study looks at whether people with oral lichen planus, a chronic mouth condition, have higher risks for heart problems or blood clots. Researchers will check blood samples from 55 adults for natural anticoagulant deficiencies and antiphospholipid antibodies. The goal is to b…

This study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will track 50 newly diagnosed patients to see how different gene patterns affect treatment resp…

This study will create and test simple picture-based tools (pictograms) to help children aged 8 to 17 describe symptoms like constipation, bloating, and stomach pain. Many kids struggle to explain what they feel, which can lead to misdiagnosis. The goal is to see if these pictogr…

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…

This study looks at how sex hormones, especially during pregnancy, change the immune cells in the skin. Researchers will compare pregnant women, non-pregnant women, and men, both with and without a skin condition called hidradenitis suppurativa. The goal is to understand how horm…

This study will follow 100 Canadian adults with hidradenitis suppurativa (HS), a painful skin condition, to measure how it affects their work and daily life. Participants will fill out questionnaires about work productivity and quality of life. No treatment is given—the goal is t…

This study will develop and test a digital twin-haptic mixed reality simulation to teach nursing students how to manage pressure injuries (bedsores). About 130 second-year nursing students will be randomly assigned to either the mixed reality simulation or a standard high-fidelit…

This study will measure 12 immune-signaling proteins (cytokines) in the blood of 125 people with vitiligo and healthy volunteers. The goal is to create a model that can predict when the disease will become active and how well a patient will respond to treatment. Currently, doctor…

This study aims to find the best way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how complete, …

This study aims to find biological markers (biomarkers) in blood, tears, and eye cells from 110 adults with seven rare eye diseases. Researchers will compare these markers between patients and healthy controls to see if they differ and if they relate to disease symptoms. The goal…

This study compares two types of numbing medicine for upper limb surgery: a standard one and a longer-acting version. Researchers want to see how quickly the diaphragm (the main breathing muscle) recovers after the nerve block. 120 adults having arm or hand surgery will be split …

This study aims to better understand why some people's immune cells attack their own body, causing autoimmune diseases like lupus and scleroderma. Researchers will analyze blood samples from 200 adults with these conditions to identify and measure specific harmful immune cells. T…