Could a booster shot shield transplant patients from shingles?
NCT ID NCT07443709
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether an extra dose of the shingles vaccine (Shingrix) can boost immunity in people who have had a solid-organ transplant, like a kidney or liver. About 30% of transplant patients still get shingles after the standard two-dose vaccine, likely due to immune-suppressing medications. The trial will randomly assign 75 participants to receive either the booster or no booster, then measure antibody levels and track safety for one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Shingrix (recombinant zoster vaccine) booster dose
- What this could lead to
- If it works, this could lead to a simple booster shot that helps prevent shingles in transplant patients, reducing severe complications and hospital visits.
- What could go wrong
- This is a small, early-phase pilot study (75 people) and may not prove the booster is effective or safe for all transplant patients. Immune responses can vary, and there is a risk of side effects or organ rejection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Lausanne University Hospital
Lausanne, Canton of Vaud, 1011, Switzerland