Can a pill clear psoriasis on hands and feet?
NCT ID NCT07752108
First seen Aug 07, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This trial tests whether an oral medication called zasocitinib (TAK-279) can reduce the redness, thickening, scaling, and painful cracks of palmoplantar psoriasis, a type of psoriasis that affects the palms and soles. Adults with moderate-to-severe non-pustular palmoplantar psoriasis will take the drug daily for up to a year or more, with regular clinic visits to monitor progress. The study aims to see if the treatment can make the skin clear or almost clear, and whether it improves the area affected by psoriasis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- zasocitinib (TAK-279), an oral tablet
- What this could lead to
- If successful, this could offer a new oral treatment option for people with hard-to-treat palmoplantar psoriasis, potentially improving quality of life by reducing pain, itching, and scaling on hands and feet.
- What could go wrong
- This is an early-phase study with a small number of participants, so results may not apply to everyone. The drug may not work as hoped or could cause side effects, and long-term benefits are not yet known.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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