Could botox calm the painful skin flares of hidradenitis suppurativa?

NCT ID NCT07756346

Not yet recruiting Disease control Sponsor: University of Massachusetts, Worcester Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether injecting botulinum toxin (Botox) into skin affected by hidradenitis suppurativa (HS) can reduce the number of painful abscesses, nodules, and draining tunnels, and ease pain. About 40 people with HS will receive either Botox or a saline placebo injection twice, three months apart. Researchers will also use skin biopsies and ultrasound to see how the treatment affects the skin and underlying inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Botulinum toxin A (Botox) injected into affected skin areas
What this could lead to: If effective, this could offer a new treatment option for hidradenitis suppurativa, reducing painful lesions and improving quality of life.
What could go wrong: This is a small, early-stage trial. The treatment may not work for everyone, and there are risks like injection-site reactions or temporary muscle weakness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hidradenitis suppurativa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIDRADENITIS SUPPURATIVA (HS)

Contacts and locations

Locations

UMass Chan Medical School

Worcester, Massachusetts, 01605, United States

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