University Of Massachusetts, Worcester

This study tests a program for adults with type 2 diabetes who are leaving the hospital. Participants will work with a patient navigator to address unmet social needs like food, housing, or transportation. The goal is to see if this support reduces emergency visits and readmissio…

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests whether adding lumateperone (Caplyta) to clozapine can reduce common side effects like weight gain and high blood sugar in people with schizophrenia or schizoaffective disorder. Fifty participants will take either lumateperone or a placebo for 12 weeks while cont…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study tests whether having school staff supervise children taking their asthma medication can improve symptoms and reduce hospital visits. About 350 children aged 5-14 with poorly controlled asthma will either receive school-supervised therapy plus an educational workbook, o…

This study compares home-based skilled nursing and rehab care to traditional facility-based care for 650 adults leaving the hospital. Participants are randomly assigned to recover at home with a care team or go to a skilled nursing facility. The main goal is to see if home care l…

This study compares continuous glucose monitors (CGMs) to standard fingerstick testing in 180 pregnant women with type 2 diabetes. The goal is to see if CGMs reduce the number of large babies and improve blood sugar control. Participants will use either a CGM or traditional finge…

This study is testing whether Botox injections can reduce inflammation in people with hidradenitis suppurativa (HS), a chronic skin condition that causes painful lumps. Researchers believe that blocking certain nerve signals may calm the immune response. The study will enroll 20 …

This study tests whether screening for gestational diabetes in the first trimester (instead of the usual third trimester) can detect the condition earlier in high-risk pregnancies. Researchers will use a combination of risk factors and blood markers to predict GDM. The goal is to…

This study is testing whether an artificial intelligence program called Mirai can better identify women at high risk for breast cancer compared to traditional risk models. Researchers will invite 200 women flagged as high-risk by Mirai to receive an additional breast MRI. The goa…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study tests whether providing health education and helping mothers form supportive social networks can prevent dental cavities and unhealthy weight gain in their young children. About 460 Bangladeshi mothers and their children (ages 1-4) will take part. One group gets educat…

This study looks at how to keep an HIV prevention program running well in Bahamian schools over several years. Researchers will test different support strategies for teachers, like regular check-ins and mentorship. About 3,705 students and teachers will take part, and the study w…

This study is testing a mobile app designed to help young Thai adults (ages 18-29) overcome stigma and start or stick with HIV prevention pills (PrEP). The app uses motivational interviewing and tailored content delivered over four sessions. Researchers will enroll 154 participan…

This study is testing a mobile health app called Moms@Home to help pregnant women with high blood pressure monitor their readings at home. About 100 women with gestational or chronic hypertension will use the app and share their home blood pressure data. The goal is to see if the…

This study tests whether adding poverty alleviation (like financial support) to group talk therapy helps low-income rural women in Bangladesh with depression more than therapy alone. Six hundred women aged 18-45 with depression and economic hardship will be randomly assigned to e…

This study tests whether a digital avatar (virtual coach) program can help young adults aged 18-29 who come to the emergency department with alcohol misuse and suicidal thoughts. About 60 participants will either use the avatar program with supportive texts or a free suicide safe…

This pilot study is testing whether a structured program of exercise, nutrition counseling, and support—called prehabilitation—can help adults with pancreatic cancer get stronger before surgery. Twenty participants will follow the program while receiving chemotherapy before their…

This study tests whether a specific injection technique called erector spinae plane block (ESPB) reduces pain and opioid use after lumbar spinal fusion better than standard subcutaneous anesthesia. Researchers will enroll 66 adults scheduled for one- or two-level lumbar fusion. P…

This pilot study tests a therapy called Deaf-MET, which is a version of motivational enhancement therapy designed specifically for Deaf adults who use American Sign Language. The goal is to see if the therapy is practical, acceptable, and helps participants become more ready to c…

This study is testing a digital platform called Jaspr Health that provides suicide risk assessment and coping skills to people in the emergency department who are having suicidal thoughts. About 670 participants will use the app with help from a research coordinator and continue …

This study tests a new program called PEACE, where specially trained paramedics visit people with COPD at home when their symptoms suddenly worsen. The goal is to treat flare-ups early and avoid trips to the emergency room. The study will enroll 50 adults with moderate to severe …

This study tests whether injecting sterile saline into the space behind the pubic bone before placing a sling for stress incontinence can reduce the risk of accidentally poking the bladder. About 300 women scheduled for this surgery will be randomly assigned to receive the inject…

This study follows 1000 younger adults (ages 30-55) who smoke or are at risk for COPD. Researchers will use CT scans, blood and sputum tests, and lung function tests to find early warning signs of the disease. The goal is to better understand how COPD starts and how to catch it s…

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. One approach focuses on improving care within doctor's offices, while the other partners with community groups. About 1,270 participants across 32 U.S. clinics will …

This study looks at whether giving weekly cash payments to low-income mothers of preterm babies can help them visit the NICU more often. The goal is to see if more visits lead to more breastfeeding and skin-to-skin care, which are good for the baby's health. About 420 mothers wil…

This study uses remote eye-tracking to see which vaccine promotion messages grab attention best in rural New England adults. Participants view sample social media posts from experts or influencers while their eye movements are tracked. The goal is to find the most effective messa…

This study follows 500 adults with progressive pulmonary fibrosis (a type of lung scarring) for 24 months. Researchers will collect medical images, lung function tests, and blood samples to better classify the disease and predict its course. The goal is to improve how doctors ide…

This study tests a training program called MRWeight to help medical residents improve their weight management counseling skills. About 630 first-year residents will either receive the program (sessions and email modules) or standard training. Their counseling skills will be asses…