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Could a vaccine protect your heart? study tests shingles and RSV shots against artery plaque

NCT ID NCT07712380

Not yet recruiting Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study investigates whether two common vaccines—the shingles vaccine (RZV) and an RSV vaccine (RSVPreF3)—can slow the buildup of fatty plaque in the coronary arteries. The trial enrolls adults aged 50 and older who are at risk for cardiovascular events. Participants receive either one of the vaccines or a placebo, and changes in plaque volume are measured using CT scans over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
adjuvanted recombinant zoster vaccine (RZV) or adjuvanted respiratory syncytial virus PreFusion protein 3 (RSVPreF3) vaccine
What this could lead to
If successful, this could show that common vaccines have an unexpected benefit: slowing the progression of artery plaque and reducing heart attack risk.
What could go wrong
This is an early exploratory study, so the vaccines may have no effect on plaque. Also, any benefit would be modest and not a replacement for standard heart treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder coronary artery disorder herpes zoster

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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