Scientists heat up itch research to uncover how skin and brain talk

NCT ID NCT07395882

Not yet recruiting Knowledge-focused Sponsor: Aalborg University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to create a reliable, long-lasting itch model by combining heat with substances that cause itching, like histamine and cowhage. Researchers will measure how 28 healthy adults rate their itch and pain sensations, along with skin blood flow. The goal is to better understand the neurophysiology of itch, which could improve future research on itch treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cowhage, histamine, and heat
What this could lead to: If successful, this could lead to better lab models for studying itch, helping future itch treatments.
What could go wrong: This is a small, early-stage observational study in healthy volunteers, not a treatment trial. Results may not apply to people with chronic itch conditions.

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Conditions

The condition(s) this trial relates to.

miliaria Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAT ITCH ITCHING

Contacts and locations

Locations

Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark

Aalborg, Aalborg, 9620, Denmark

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