New drug could shorten hospital stays for rare drug reaction

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult patients (minimum 18year-old) 2. diagnosed at D0 (= baseline and inclusion) with DRESS defined by: 1. with a REGIScar score at D0 calculated at at least 4 (4 or 5: probable DRESS; \>5: definite case of DRESS), see Annex: REGIScar criteria 2. Skin eruption with an onset considered as compatible with a DRESS syndrome according to the investigator's opinion after the uptake of one or several drug(s) 3. AND Fever ≥ 38°C at the time of the examination or notion of a thermal peak ≥ 38°C in the preceding 72 hours. 4. At least 1 organ disorder compatible with the diagnosis of DRESS syndrome among the following disorders: * Adenopathies present in at least 2 different sites and ≥ 1 cm in size * Acute hepatitis defined by : * Elevation of liver enzymes in serum: ALAT (Alanine Aminotransferase) and/or ASAT (Aspartate Aminotransferase) * AND/OR an increase in serum total bilirubin, according to the standards of the local analysis laboratory (in the absence of a history of liver disease: ASAT and/or ALAT ≥ 3N (=3 times normal) * AND/OR total bilirubin ≥ 2N * Acute renal failure defined by : * An increase in creatinine according to local laboratory standards * AND a sterile cytobacteriological examination (in the absence of a history of renal disease: creatininaemia ≥ 1.5N * AND/OR increase in creatinine ≥ 0.3 mg/dl (or ≥ 26.5 mol/L) * AND/OR urine output \< 0.3 ml/kg/h (over ≥ 24h). * Pulmonary impairment defined by: * Oxygen saturation (SpO2) measured by pulse oximetry ≤ 95% in room air * And/or the presence of an interstitial syndrome on a standard chest X-ray or a CT scan of the chest (in the absence of any other cause of lung damage). 3. With eosinophilia (blood eosinophil count ≥ 500/mm3 or ≥0.5 G/L). 4. Patient having given written informed consent 5. patient with social insurance Exclusion Criteria: 1. Patients \<18 year-old 2. Patients with DRESS with REGIScar score \<4 3. Patients without skin eruption at baseline 4. Eosinophils blood count \<500/mm3 or \< 0.5 G/L at baseline 5. Patients with contra-indication to blood samples dedicated to the biocollection, according to the investigator's opinion 6. Patients with contra-indication to stop the culprit drug(s) involved in DRESS 7. Past history of hypersensitivity to biological drugs 8. Patients who received a previous anti-IL5 or anti-IL5 receptor therapy within 5 half lives (= 4 months) before inclusion 9. Patients with a contra-indication of topical corticosteroids (mainly a past history of contact eczema with clobetasol propionate) 10. Pregnancy and lactation