One pill may tame both itchy skin and stubborn liver disease
NCT ID NCT07678645
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway involved in both itching and liver inflammation. Researchers will measure changes in itch severity, liver enzyme levels, and liver stiffness over 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- upadacitinib
- What this could lead to
- If it works, this could offer a new treatment option for people with both atopic dermatitis and hard-to-treat autoimmune liver disease, potentially easing itching and slowing liver damage.
- What could go wrong
- This is a small, early-phase study with no placebo group, so results may not be conclusive. Upadacitinib can have side effects like infections or blood clots.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
RenJi Hospital
Shanghai, Shanghai Municipality, 200001, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new antibody calm severe eczema?
- Can a common cholesterol drug help manage a rare liver disease?
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- Menthol gloves may offer quick itch relief for eczema sufferers