Renji Hospital

This early-phase trial is testing a new treatment called GC012F (CD19-BCMA CAR-T cells) for people with severe lupus that hasn't improved with standard medications. The therapy uses a patient's own immune cells, modified to target and destroy faulty B cells driving the disease. T…

This study compares two medical devices used to remove large blood clots from the leg veins. About 180 adults with acute deep vein thrombosis (DVT) will receive either the ClotTriever System or an aspiration device. The goal is to see which device clears clots better and reduces …

This study is testing whether adding an immunotherapy drug called QL1706 to standard chemotherapy before surgery can improve outcomes for people with HR-positive, HER2-negative breast cancer. About 55 participants will receive the combination, and researchers will measure how man…

This phase 2 trial is testing whether adding the immunotherapy drug serplulimab to standard chemotherapy before surgery can improve outcomes for people with triple-negative breast cancer. The study will enroll 46 participants and measure how many achieve a complete response (no c…

This trial tests a drug called Disitamab vedotin (RC48-ADC) in 36 people with HER2-low advanced breast cancer that cannot be cured. Participants have had only one prior chemotherapy. The goal is to see if the drug can shrink tumors and how safe it is. This is an early study, so r…

This study tests a new approach to remove blood clots from deep leg veins in people with acute deep vein thrombosis (DVT). The standard method accesses the vein behind the knee, while the new method uses veins in the calf or the opposite leg. Researchers want to see if the new ap…

This study tests whether washing out infected fluid from the brain's cavities (ventricular irrigation) can improve survival and recovery in people with severe ventriculitis, a life-threatening brain infection. About 310 adults aged 18-65 with confirmed ventriculitis will be rando…

This study is testing a drug called dalpiciclib in people with a specific type of advanced breast cancer (HR-positive, HER2-negative). The goal is to see how long the drug can keep the cancer from growing and what side effects it causes. About 103 participants will take dalpicicl…

This study tests a special filter device designed to catch debris during procedures that clear blockages in the leg arteries. The goal is to prevent small particles from traveling downstream and causing serious complications. About 150 adults with leg artery disease will be enrol…

This phase 2 trial tests two drugs—RC48 and Tislelizumab—given before kidney-sparing surgery in 20 people with high-risk upper tract urothelial carcinoma. The goal is to control the cancer while preserving the kidney, avoiding complete removal. Researchers will track how long pat…

This study tests whether giving a combination of adebrelimab (an immunotherapy) plus chemotherapy before bladder removal surgery can completely eliminate neuroendocrine bladder cancer in 22 adults. Participants will receive up to 4 cycles of the drug combo before surgery. The mai…

This study tests whether a medicine called tranexamic acid can reduce blood loss during adult liver transplant surgery. About 1,546 people will be randomly assigned to receive either the drug or a placebo. The main goal is to see if the drug works better than placebo at controlli…

This Phase 3 trial is testing whether extending treatment with the drug pyrotinib (either continuously or in cycles) can help prevent HER2-positive breast cancer from returning. About 488 adults who have already completed initial therapy will be randomly assigned to one of two ex…

This study is looking at how well a drug called Disitamab vedotin (RC48-ADC) works for breast cancer patients in real-world settings, outside of strict clinical trials. Researchers will track 45 patients to see how long they live without their cancer getting worse and what side e…

This study tests whether adding the drug pyrotinib to standard trastuzumab therapy can lower the risk of cancer coming back in women with HER2-positive breast cancer who still have cancer cells after initial treatment. About 316 women will take pyrotinib daily for a year. Researc…

This study tests whether a long-term rehabilitation program—combining home exercise and breathing muscle training—can improve clinical outcomes and heart-lung function in people with pulmonary arterial hypertension. About 104 adults with stable disease will be randomly assigned t…

This study is testing a new type of PET scan that uses special radioactive tracers to find and map solid tumors in the body. The tracers target a protein called Trop2, which is often found on cancer cells. Researchers will enroll 400 people with various cancers (including bladder…

This study tests a special PET/CT scan that uses radioactive tracers to find cancers that have a protein called CD70 on their surface. The cancers being studied include kidney cancer, lymphoma, and nasopharyngeal cancer. About 300 adults will receive an injection of the tracer an…

This study tests two new radioactive imaging probes that target specific markers on breast cancer cells. Researchers will use PET/CT scans to see how well these probes find tumors and their spread in 200 women with breast cancer. The goal is to improve diagnosis and help guide tr…

This study tests a new radioactive imaging agent called [18F]RCCB6 for PET/CT scans to see if it can better detect kidney cancer, especially the most common type, clear cell renal cell carcinoma. Researchers will enroll 300 adults with confirmed or suspected kidney cancer. The go…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study tests three new radioactive imaging probes that attach to proteins found on pancreatic cancer cells. By using PET/CT scans, doctors hope to see where the cancer has spread and predict which patients might respond to targeted drugs. The trial will enroll 90 adults with …

This study tests whether electrically pacing the diaphragm through a vein near the heart can improve heart function in people with heart failure. Ten adults who are already scheduled for a heart device (CRT) will have an extra pacing lead placed temporarily. Researchers will chec…

This study follows 275 infants who received a liver transplant to see how they grow over time. Researchers want to understand growth patterns and find ways to improve care. The study is observational, meaning no new treatment is being tested.

This study will review the medical records of 10 patients who developed acute pancreatitis within two weeks after a procedure to remove blood clots (percutaneous mechanical thrombectomy). The goal is to find out how often this complication happens, what patient or procedure facto…

This study looks at 3,000 people with primary biliary cholangitis (PBC) to see how their blood levels of alkaline phosphatase (ALP) after treatment relate to their risk of liver complications. The goal is to create a model that predicts who will do well and who might need stronge…

This study is looking at how different treatments given before surgery (like chemo, radiation, or hormone therapy) affect breast cancer patients' response and long-term survival. Researchers will compare results based on the type of treatment and patient characteristics. The goal…

This study is testing a device called GILUPI CellCollector® that captures circulating tumor cells (CTCs) from a vein in breast cancer patients who have already completed surgery and chemotherapy. The goal is to see if the presence of these cells can help predict whether the cance…

This study looks at 2,000 people with a type of brain bleed called an epidural hematoma to see which surgery works best. Researchers will track recovery over time using a scale that measures how well people can function. The goal is to find the safest and most effective surgical …

This study looks at whether replacing a narrowed heart valve (TAVI) can reverse damage to the heart muscle in people with severe aortic stenosis. Researchers will use special PET scans to measure scarring and remodeling in the heart before and 6 months after the procedure. The go…

This study looks at whether tumor DNA found in blood and urine can help predict if cancer will come back after surgery in people with a rare type of bladder and kidney cancer. Researchers will follow 84 patients who have had surgery and are receiving chemotherapy or immunotherapy…

This study is for adults who have had a liver transplant and now have kidney issues. Researchers want to learn how often kidney function gets worse and what factors might cause that decline. They will look at results from kidney biopsies already done in the past 3 months. The goa…

The SMILE study is tracking 10,000 adults aged 18 and older to see how sarcopenia (age-related muscle loss) and metabolic diseases like diabetes influence overall health and lifespan. Researchers will collect data from medical records, tests, and surveys over time. This is an obs…