Renji Hospital

This study is testing whether adding a new immunotherapy drug (QL1706) to standard chemotherapy before surgery can help eliminate tumors in people with hormone receptor-positive, HER2-negative breast cancer. About 55 adults with early-stage disease will receive the combination, a…

This study tests whether adding the drug serplulimab to standard chemotherapy before surgery can improve outcomes for people with triple-negative breast cancer. About 46 women aged 18-70 with early-stage disease will receive the combination. The main goal is to see if the cancer …

This study looks at how well and how safely the drug dalpiciclib works for people with a certain type of advanced breast cancer (HR+/HER2-). About 103 participants will take the drug, and researchers will track how long the cancer stays under control and any side effects. The goa…

This early study tests if electrically pacing the diaphragm (the muscle that helps you breathe) can improve heart function in people with heart failure. Ten adults already scheduled for a heart device will get temporary pacing during their procedure. Researchers will check if it'…

This study tests whether tranexamic acid, a drug that helps blood clot, can reduce blood loss during adult liver transplant surgery. About 1,546 adults receiving a new liver will be randomly given either the drug or a placebo. The goal is to see if the drug lowers bleeding withou…

This study compares three methods of removing blood clots from deep leg veins in people with acute deep vein thrombosis (DVT). The goal is to see if newer approaches work as well as the standard method and reduce the risk of long-term complications like post-thrombotic syndrome. …

This study tests whether giving two drugs (disitamab vedotin and tislelizumab) before a kidney-sparing surgery can help people with high-risk upper urinary tract cancer avoid losing their kidney. About 20 participants will receive the drugs every 3 weeks, then undergo surgery to …

This study tests whether giving a combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (etoposide and cisplatin) before bladder removal surgery can completely eliminate a rare and aggressive type of bladder cancer (neuroendocrine carcinoma). About 22 adu…

This study tests a special filter device placed in the leg artery to catch debris during procedures that clear blockages. The goal is to prevent small particles from traveling downstream and causing serious complications like amputation or heart attack. About 150 adults with leg …

This study tests a drug called Disitamab vedotin in 36 women with advanced breast cancer that has low HER2 levels and has spread. Participants have had only one previous chemotherapy and no prior antibody-drug treatments. The goal is to see if the drug can shrink tumors and contr…

This study tests whether adding the drug pyrotinib to standard trastuzumab therapy can further reduce the chance of breast cancer returning in women with HER2-positive breast cancer who still have cancer cells after initial chemotherapy and anti-HER2 treatment. About 316 women wi…

This study is testing a drug called Disitamab vedotin (RC48-ADC) in 45 people with breast cancer. The goal is to see how long the drug can keep the cancer from growing and to check for side effects. Participants must have already used or be currently using this drug as part of th…

This study tests whether washing out infected fluid from the brain's cavities (ventricular irrigation) is safe and works better than standard antibiotics alone for ventriculitis, a severe brain infection with a high death rate. About 310 adults aged 18-65 with confirmed ventricul…

This study is for people with HER2-positive breast cancer who have already had initial treatment. It compares taking the drug pyrotinib every day versus taking it on a schedule with breaks. The goal is to see if intermittent dosing works as well as continuous dosing to prevent th…

This study is testing a new type of PET/CT imaging that uses special probes to target and highlight digestive system cancers, including cancers of the liver, stomach, colon, pancreas, and more. Researchers want to see how these probes spread in the body and how well they can find…

This study tests a new type of PET scan that targets a protein called CD70, which is found on some cancer cells. The goal is to see if this scan can better detect kidney cancer, lymphoma, and nasopharyngeal cancer compared to standard scans. About 300 adults with known or suspect…

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study is testing two new imaging agents that light up breast cancer cells on PET scans. Researchers want to see if these agents can find tumors and their spread more accurately than current methods. About 200 women with breast cancer or suspected breast cancer will receive t…

This study is testing special PET imaging probes that light up pancreatic cancer cells. The goal is to see if these scans can find tumors and show which patients might benefit from targeted therapies. About 90 adults with pancreatic cancer will receive an injection of a radioacti…

This study aims to see if a new imaging agent called [18F]RCCB6 can improve the detection of kidney cancer, especially the most common type (clear cell renal cell carcinoma). Researchers will enroll 300 adults with confirmed or suspected kidney cancer to measure how well the trac…

This study tests whether long-term rehabilitation training can improve heart and lung function in people with pulmonary arterial hypertension (PAH). About 104 adults with stable PAH will be randomly assigned to either a rehab program or standard care. Researchers will measure wal…

This study looks at whether DNA from tumors found in blood and urine can help detect leftover cancer cells and predict if the cancer will come back after surgery. About 84 people with advanced upper tract cancer who had their kidney and ureter removed will provide samples over ti…

This study looks at 3,000 adults with primary biliary cholangitis (PBC) to see how changes in a key blood marker (alkaline phosphatase) after treatment relate to their risk of liver complications or death. Researchers aim to build a model that predicts survival without major live…

This study follows 2000 people with traumatic brain injury who need surgery for a blood clot on the brain (epidural hematoma). Researchers will compare different surgical methods to see which leads to better recovery and fewer complications. The goal is to find the best treatment…

This study is following 10,000 adults aged 18 and older to learn how muscle loss (sarcopenia), metabolic diseases, and aging are connected. Researchers will collect health data, lifestyle info, and biosamples over time. The goal is to understand what leads to earlier death and po…

This study looks at whether fixing a tight heart valve with a procedure called TAVI can reverse damage to the heart muscle. Researchers will use a special PET scan to measure scarring in the heart before and 6 months after TAVI in 25 patients. A control group of patients who do n…

This study is for people who have had a liver transplant and now have kidney issues. Researchers will use kidney biopsies to learn why kidney problems happen and how they get worse over time. The goal is to better understand the disease, not to test a new treatment.

This study is testing whether a special blood test can help predict if breast cancer will come back in people who have already had chemotherapy and surgery. Researchers will follow 484 women for several years to see if finding cancer cells in the blood is linked to the cancer ret…

This study follows 275 infants who received a liver transplant to see how they grow and develop over time. Researchers want to understand growth patterns so they can create better care plans and follow-up schedules. The study does not test a new treatment but gathers information …

This study is looking at a rare but serious side effect—acute pancreatitis—that can happen after a procedure to remove blood clots from the body. Researchers will review medical records of 10 patients to find out how often this complication occurs, what might make it more likely,…

This study aims to understand how well pre-operative therapy works for breast cancer and how it impacts long-term survival. Researchers will compare different treatment plans and patient characteristics in about 488 women with early or advanced breast cancer. The goal is to find …