Heart valve fix may heal scarred muscle, small study hints

NCT ID NCT07335900

Recruiting now Knowledge-focused Sponsor: RenJi Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether replacing a narrowed heart valve (TAVI) can reverse damage to the heart muscle in people with severe aortic stenosis. Researchers will use special PET scans to measure scarring and remodeling in the heart before and 6 months after the procedure. The goal is to understand if relieving the blockage helps the heart heal and work better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcatheter Aortic Valve Implantation (TAVI) procedure
What this could lead to: If successful, this could show that TAVI not only fixes the valve but also helps reverse heart muscle scarring and improve heart function.
What could go wrong: This is a small, early-stage imaging study (25 people) with no control group for the procedure. It measures changes in scans, not long-term health outcomes, so results may not lead to direct treatment changes.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE AORTIC VALVE STENOSIS

Contacts and locations

Locations

Renji Hospital,Shanghai
RECRUITING

Shanghai, 201203, China

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