CT scan could guide safer blood thinner use after TAVI

NCT ID NCT06168370

Recruiting now Disease control Sponsor: St. Antonius Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a CT scan 3 months after TAVI (aortic valve replacement) can help doctors decide who needs blood thinners and who can stop them. Currently, patients take aspirin for life, which can cause bleeding. The trial will enroll 2,500 people and compare this personalized approach to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: apixaban (a blood thinner)
What this could lead to: If successful, this approach could reduce the risk of blood clots and strokes after TAVI without increasing bleeding, potentially replacing lifelong aspirin for many patients.
What could go wrong: This is a large trial but still experimental. The CT-guided strategy may not prove better than standard care, and some patients may still experience bleeding or clotting events.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE AORTIC VALVE STENOSIS

Contacts and locations

Locations

St. Antonius Hospital
RECRUITING

Nieuwegein, Netherlands

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