Renji Hospital

This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway invo…

This study tests whether removing a blood clot from a specific thigh vein (the profunda femoris vein) during standard treatment for a large leg vein clot can prevent long-term complications like pain and swelling. About 140 adults with recent leg clots will be randomly assigned t…

This study tests whether giving a combination of two drugs (a PD-L1 inhibitor called TQB2450 and anlotinib) before surgery can shrink complex kidney tumors enough to allow surgeons to remove only the tumor and save the rest of the kidney. About 33 adults with advanced clear cell …

This study tests a two-drug treatment (disitamab vedotin plus tislelizumab) for people with a rare, aggressive cancer of the upper urinary tract that has a specific marker (HER2-positive). The goal is to shrink the tumor so that the kidney can be saved, avoiding complete removal.…

This study looks at two ways to treat people with a type of heart attack (NSTE-ACS) who have multiple blocked arteries. One group gets all blockages fixed during the same emergency procedure, while the other group fixes the main blockage first and the others later. The goal is to…

This phase 2 trial tests a virus-based drug given directly into the bladder for people with high-risk non-muscle invasive bladder cancer. The virus is designed to attack cancer cells and trigger the immune system. About 18 participants will receive increasing doses to find the sa…

This study tests whether using a smartwatch combined with artificial intelligence can improve recovery for people who have had a heart attack. 200 adults aged 18-75 who recently had a heart attack and a stent placed will wear a smartwatch that tracks health data. The AI analyzes …

This study tests a device called a flow diverter to treat brain aneurysms that are not balloon-shaped. The goal is to block blood flow into the aneurysm, helping it heal and preventing rupture. About 168 adults aged 18 to 80 will be enrolled, and the main outcome is complete bloc…

This phase 2 trial tests a new drug called JS004, a BTLA antibody, combined with toripalimab (an immunotherapy) in 31 people with advanced kidney cancer that has worsened after prior immunotherapy. The goal is to see if the combination can shrink tumors or slow disease progressio…

This study tests whether a single dose of the drug disitamab vedotin, given directly into the bladder right after kidney removal surgery, can prevent bladder cancer from coming back. It involves 49 adults with HER2-positive upper tract cancer who are at risk for recurrence. The m…

This study tests whether a non-invasive brain stimulation technique called TMS can shorten the duration of delirium (sudden confusion) that often occurs after heart surgery in people aged 50 and older. Half of the 144 participants will receive real TMS, and half will receive a sh…