Can removing the prostate boost drug therapy in advanced cancer?
NCT ID NCT06306612
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial is testing whether adding surgery to remove the prostate to standard drug therapy helps men with advanced, hormone-sensitive prostate cancer that has spread to multiple sites. Participants will receive either the usual drug treatment alone or the same drugs plus surgery. The study aims to see if the combined approach delays cancer progression and improves survival compared to standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Combination of chemotherapy (docetaxel), hormone therapy (darolutamide), and surgery to remove the prostate (cytoreductive prostatectomy)
- What this could lead to
- If successful, this could establish a new treatment approach that delays cancer progression and improves survival for men with advanced prostate cancer.
- What could go wrong
- The trial is early and not yet proven; surgery plus drugs may not improve outcomes over standard care and could carry added risks from the operation and stronger side effects from combined treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Renji Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, 200127, China
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