Brain-Wash breakthrough? new trial takes on deadly ventriculitis

NCT ID NCT06358209

Recruiting now Disease control Sponsor: RenJi Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether washing out infected fluid from the brain's cavities (ventricular irrigation) can improve survival and recovery in people with severe ventriculitis, a life-threatening brain infection. About 310 adults aged 18-65 with confirmed ventriculitis will be randomly assigned to receive either standard antibiotic treatment or standard treatment plus ventricular irrigation. The goal is to see if the irrigation procedure leads to higher cure rates and fewer long-term problems like brain damage or epilepsy.

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Conditions

The condition(s) this trial relates to.

central nervous system infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CENTRAL NERVOUS SYSTEM INFECTIONS

Contacts and locations

Locations

904 Hospital of the People's Liberation Army Joint Logistic Support Force
NOT_YET_RECRUITING

Wuxi, Jiangsu, China
Affiliated Hospital of Nantong University
NOT_YET_RECRUITING

Nantong, Jiangsu, China
Affiliated Hospital of Yangzhou University
NOT_YET_RECRUITING

Yangzhou, Jiangsu, China
First Affiliated Hospital of Zhejiang University
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Ganzhou People's Hospital
NOT_YET_RECRUITING

Ganzhou, Jiangxi, China
Henan Provincial People's Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, China
Inner Mongolia People's Hospital
NOT_YET_RECRUITING

Hohhot, The Nei Monggol Autonomous Region, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, China
Nanfang Hospital, Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
Nanjing Drum Tower Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, China
Qilu Hospital of Shandong University
NOT_YET_RECRUITING

Jinan, Shandong, China
Renji Hospital, School of Medicine, Shanghai Jiaotong University
RECRUITING

Shanghai, Shanghai Municipality, China
Shanghai Donglei Brain Hospital
RECRUITING

Shanghai, Shanghai Municipality, China
Shanghai East Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Shanghai Tenth People's Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Shenzhen Second People's Hospital
NOT_YET_RECRUITING

Shenzhen, Guangdong, China
South taihu hospital affiliated to huzhou college
RECRUITING

Huzhou, Zhejiang, China
The First Affiliated Hospital of Fujian Medical University
NOT_YET_RECRUITING

Fuzhou, Fujian, China
The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Harbin, Heilongjiang, China
The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, China
The First Affiliated Hospital of University of Science and Technology of China
NOT_YET_RECRUITING

Hefei, Anhui, China
The First Affiliated Hospital of Wannan Medical College
NOT_YET_RECRUITING

Wuhu, Anhui, China
The First Affiliated Hospital of Xinjiang Medical University
NOT_YET_RECRUITING

Ürümqi, Xinjiang Uygur Autonomous Region, China
The Fourth Affiliated Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, China
The Second Affiliated Hospital of Air Force Medical University
NOT_YET_RECRUITING

Xi'an, Shaanxi, China
The Second Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, China
The Second Affiliated Hospital of Naval Medical University
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
The Second People's Hospital of Anhui Province
NOT_YET_RECRUITING

Hefei, Anhui, China
The affiliated people's hospital of ningbo university
NOT_YET_RECRUITING

Ningbo, Zhejiang, China
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, China
West China Hospital, Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, China
Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, China
Xuanwu Hospital Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, China
Zhongshan Hospital of Traditional Chinese Medicine
NOT_YET_RECRUITING

Zhongshan, Guangdong, China
Zhujiang Hospital of Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, China

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