Immunotherapy plus chemo shows promise in Triple-Negative breast cancer trial
NCT ID NCT07283692
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether adding the immunotherapy drug serplulimab to standard chemotherapy before surgery can improve outcomes for people with triple-negative breast cancer. The study will enroll 46 participants and measure how many achieve a complete response (no cancer cells left in the removed tissue). It also tracks side effects to assess safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Serplulimab (an immunotherapy drug) combined with paclitaxel and carboplatin (chemotherapy drugs)
- What this could lead to
- If successful, this combination could become a new standard neoadjuvant treatment for triple-negative breast cancer, potentially increasing the chance of a complete response before surgery.
- What could go wrong
- This is an early-phase, single-arm trial with only 46 participants, so results may not apply broadly. Immunotherapy can cause immune-related side effects, and the added benefit over existing treatments is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Renji Hospital, School of Medicine, Shanghai Jiaotong University
RECRUITINGShanghai, 200127, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a High-Fiber diet shield the gut during breast cancer therapy?
- Can mapping tumor DNA unlock personalized breast cancer care?
- Can a Two-Pronged antibody boost Chemo's power against a tough breast cancer?
- Can a new drug rally the immune system against Hard-to-Treat cancers?
- Could an oral chemo pill improve breast cancer treatment?
- Can a new nucleotide analogue boost cancer treatment?