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Menthol gloves may offer quick itch relief for eczema sufferers

NCT ID NCT07693400

Symptom relief Sponsor: Taiwan Municipal An-Nan Hospital-China Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether wearing menthol-infused gloves and foot-covers for just five minutes a day can reduce itching in people with atopic dermatitis (eczema). Participants will use the gloves five days on, two days off for four weeks, then stop for two weeks of follow-up. The trial measures itch severity, skin appearance, quality of life, and blood markers. It also explores how menthol might work through tiny particles called exosomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
menthol-based hand and foot gloves
What this could lead to
If it works, this could offer a simple, drug-free way to reduce itching in eczema patients.
What could go wrong
This is a small Phase 2 trial with only 44 participants. The effect may be modest or no better than a sham, and some people may be allergic to menthol.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Age 12 years or above. * 2\. Clinical diagnosis of atopic dermatitis based on Hanifin and Rajka criteria. * 3\. Pruritus severity defined as PP-NRS ≥ 4. * 4\. Signed the informed consent form that has been approved by the Institutional Review Board. * 5\. No changes in AD medications within four weeks before enrollment and no change in dosage during the study period. Exclusion Criteria: * 1\. Allergy to menthol. * 2\. Marked fluctuation of AD symptoms. * 3\. Secondary infection of skin lesions. * 4\. Severe peripheral vascular disease, skin lesions, or severe edema at hands/feet. * 5\. Pregnancy or breastfeeding. * 6\. Severe psychiatric conditions. * 7\. With conditions such as uremia, cirrhosis, congestive heart failure with pulmonary edema, coagulation disorders, epilepsy, alcoholism, drug abuse. * 8\. Unable to comply with the study protocol or unwilling to provide written consent. * 9\. Participation in another clinical study within the previous month. The research team may also exclude any participant who is considered unsuitable for the study.

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Conditions

The condition(s) this trial relates to.

atopic eczema Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atopic dermatitis (AD)

Contacts and locations

Locations

  • An Nan Hospital, China Medical University

    Tainan, Taiwan, 709, Taiwan

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