PRIMARY BILIARY CHOLANGITIS (PBC)
Clinical trials for PRIMARY BILIARY CHOLANGITIS (PBC) explained in plain language.
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New hope for PBC patients: drug aims to slow liver damage
Disease control Recruiting nowThis Phase 3 trial tests elafibranor, a daily pill, against a placebo in 276 adults with primary biliary cholangitis (PBC) and cirrhosis. The goal is to see if elafibranor can prevent disease worsening, such as liver failure or death, over up to 3.5 years. Researchers will also m…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Ipsen • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New combo therapy aims to tame rare liver disease
Disease control Recruiting nowThis long-term study is testing whether adding fenofibrate to standard ursodeoxycholic acid is safe for people with primary biliary cholangitis (PBC), a rare liver disease. About 300 adults who have already completed a prior fenofibrate study will take the combination and be moni…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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New combo therapy aims to tame rare liver disease in Long-Term trial
Disease control Recruiting nowThis study tests the long-term safety of combining fenofibrate with standard treatment (ursodeoxycholic acid) in 150 adults with primary biliary cholangitis, a chronic liver disease. Participants previously completed a related study and will take fenofibrate capsules daily. Resea…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Could fenofibrate be a Game-Changer for PBC patients?
Disease control Recruiting nowThis study tests whether fenofibrate, a drug used for high cholesterol, can improve liver function in adults with primary biliary cholangitis (PBC) who haven't been treated before. About 132 participants will take either fenofibrate or the standard drug UDCA for 12 months. The go…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New study aims to spot hidden liver disease before standard tests show trouble.
Diagnosis Recruiting nowThis study looks for early signs of primary biliary cholangitis (PBC) in adults who have certain antibodies (AMA) but normal liver enzyme levels (ALP). Researchers will perform liver biopsies and special blood tests on 80 participants to find clues that could lead to earlier diag…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: Hospital Universitario La Paz • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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New drug aims to lift fatigue and brain fog in liver disease patients
Symptom relief Recruiting nowThis study tests a drug called golexanolone in 84 people with primary biliary cholangitis (PBC) who suffer from significant fatigue and cognitive problems. Participants receive either the drug or a placebo for up to 28 days. The goal is to see if the drug is safe and can improve …
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE1, PHASE2 • Sponsor: Umecrine Cognition AB • Aim: Symptom relief
Last updated Jun 28, 2026 00:00 UTC
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Can exercise, diet, and counseling beat fatigue in PBC?
Symptom relief Recruiting nowThis study tests whether a program combining exercise, nutritional advice, and psychological support can reduce fatigue in people with primary biliary cholangitis (PBC). 64 participants with moderate to severe fatigue will be randomly assigned to either the rehab program or stand…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: NA • Sponsor: Hospital Clinic of Barcelona • Aim: Symptom relief
Last updated Jun 26, 2026 14:53 UTC
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3000-Patient study aims to predict PBC outcomes from blood tests
Knowledge-focused Recruiting nowThis study looks at 3,000 people with primary biliary cholangitis (PBC) to see how their blood levels of alkaline phosphatase (ALP) after treatment relate to their risk of liver complications. The goal is to create a model that predicts who will do well and who might need stronge…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: RenJi Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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4,000-Patient study aims to unlock mysteries of rare liver disease
Knowledge-focused Recruiting nowThis study will follow 4,000 people with primary biliary cholangitis (PBC), a chronic autoimmune liver disease, across multiple hospitals in China. Researchers will track survival, need for liver transplant, and common symptoms like fatigue and itching. The goal is to better unde…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:32 UTC