PRIMARY BILIARY CHOLANGITIS (PBC)
Clinical trials for PRIMARY BILIARY CHOLANGITIS (PBC) explained in plain language.
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Could fenofibrate beat standard care for PBC?
Disease control Recruiting nowThis study tests if fenofibrate can improve liver function in adults with primary biliary cholangitis (PBC) who haven't been treated before. About 132 participants will take either fenofibrate or the standard drug UDCA daily for 12 months. The goal is to see which drug better nor…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated May 17, 2026 02:44 UTC
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New combo therapy for bile duct disease moves to Long-Term safety check
Disease control Recruiting nowThis study is testing the long-term safety of combining two drugs, fenofibrate and ursodeoxycholic acid, for people with primary biliary cholangitis (PBC), a chronic liver disease. About 300 adults who have already completed a related PBC study will take the combination and be mo…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated May 17, 2026 02:38 UTC
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New hope for PBC patients: drug aims to prevent liver transplants
Disease control Recruiting nowThis study tests a daily pill called elafibranor in adults with primary biliary cholangitis (PBC) who already have liver scarring (cirrhosis). The goal is to see if the drug can prevent the disease from getting worse, reducing the need for a liver transplant or risk of death. Abo…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Ipsen • Aim: Disease control
Last updated May 14, 2026 12:01 UTC
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New combo therapy for bile duct disease moves to Long-Term safety check
Disease control Recruiting nowThis study looks at the long-term safety of taking fenofibrate together with ursodeoxycholic acid for people with primary biliary cholangitis (PBC), a chronic liver disease. About 150 adults who have already completed a previous fenofibrate study will take the combination and be …
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE3 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated May 07, 2026 18:40 UTC
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Silent liver disease unmasked: new study targets early PBC detection
Diagnosis Recruiting nowThis study looks for early signs of primary biliary cholangitis (PBC) in people who have a specific antibody (AMA) but normal liver enzyme levels (ALP). Researchers will perform a liver biopsy and special blood tests on 80 adults to find factors that predict PBC before it causes …
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: Hospital Universitario La Paz • Aim: Diagnosis
Last updated May 12, 2026 13:39 UTC
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New hope for PBC fatigue: exercise and diet may beat tiredness
Symptom relief Recruiting nowThis study tests a non-drug program of exercise, nutrition advice, and psychological support to reduce fatigue in people with primary biliary cholangitis (PBC). About 64 adults with moderate to severe fatigue will join. The goal is to see if this approach improves tiredness, qual…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: NA • Sponsor: Hospital Clinic of Barcelona • Aim: Symptom relief
Last updated May 17, 2026 02:45 UTC
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New drug trial aims to lift brain fog and fatigue in PBC patients
Symptom relief Recruiting nowThis study is testing an experimental drug called golexanolone in people with primary biliary cholangitis (PBC) who struggle with severe fatigue and cognitive problems like brain fog. The trial has two parts: first, a short safety check in 84 adults, then a longer 28-day comparis…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase: PHASE1, PHASE2 • Sponsor: Umecrine Cognition AB • Aim: Symptom relief
Last updated May 17, 2026 02:41 UTC
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Massive study aims to unlock mysteries of rare liver disease in china
Knowledge-focused Recruiting nowThis study will follow 4,000 people with primary biliary cholangitis (PBC), a chronic autoimmune liver disease, to learn more about their symptoms, treatment responses, and long-term health outcomes. Researchers want to understand why some patients do not respond well to standard…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 02:46 UTC
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Blood test levels after PBC treatment may predict survival, study finds
Knowledge-focused Recruiting nowThis study looks at 3,000 adults with primary biliary cholangitis (PBC) to see how changes in a key blood marker (alkaline phosphatase) after treatment relate to their risk of liver complications or death. Researchers aim to build a model that predicts survival without major live…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: RenJi Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 02:43 UTC