New drug aims to lift fatigue and brain fog in liver disease patients
NCT ID NCT07304843
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called golexanolone in 84 people with primary biliary cholangitis (PBC) who suffer from significant fatigue and cognitive problems. Participants receive either the drug or a placebo for up to 28 days. The goal is to see if the drug is safe and can improve quality of life, including tiredness and mental clarity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- golexanolone
- What this could lead to
- If it works, this could point toward a treatment that eases fatigue and brain fog in people with primary biliary cholangitis.
- What could go wrong
- This is an early phase 1b/2 trial with only 84 people, so results may not apply broadly. The drug may not improve symptoms or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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9 Eylul University Research and Application Hospital Department of Gastroenterology
NOT_YET_RECRUITINGBalçova, 35340, Turkey (Türkiye)
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A. Gemelli Polyclinic, Sacro Cuore Catholic University
RECRUITINGRoma, 168, Italy
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Bekes County Central Hospital
WITHDRAWNGyula, 5700, Hungary
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Dept of Gastroenterology & Hepatology Portsmouth Hospitals University NHS Trust Queen Alexandra Hospital
RECRUITINGPortsmouth, PO6 3LY, United Kingdom
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Dicle University Faculty of Medicine Department of Gastroenterology
RECRUITINGDiyarbakır, 21280, Turkey (Türkiye)
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Ege University Faculty of Medicine, Department of Gastroenterology
RECRUITINGIzmir, 35100, Turkey (Türkiye)
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Facility of CRU Hungary Ltd.
COMPLETEDKistarcsa, 2143, Hungary
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Fondazione IRCCS San Gerardo dei Tintori, Autoimmune Liver Disease Centre, ERN-Rare Liver, Department of Medicine and Surgery, Division of Gastroenterology
NOT_YET_RECRUITINGMonza, 20900, Italy
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Freeman Hospital
RECRUITINGNewcastle, NE7 7DN, United Kingdom
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Glasgow Royal Infirmary
RECRUITINGGlasgow, G4 0SF, United Kingdom
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Guy's and St Thomas' Hospital, London
RECRUITINGLondon, SE1 7EH, United Kingdom
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Hacettepe University, Fakulty of Medicine, Department of Gastroenterology and Hepatology
RECRUITINGAnkara, 06230, Turkey (Türkiye)
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Harran Üniversitesi Osmanbey Campus Department of Gastroenterology
RECRUITINGSanliurfa, 63300, Turkey (Türkiye)
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Hippokration General Hospital of Athens
RECRUITINGAthens, 11527, Greece
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Hospital 12th October, Madrid
RECRUITINGMadrid, 28041, Spain
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Hospital Clinic Barcelona
RECRUITINGBarcelona, 8036, Spain
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Hospital General Universitario Gregorio Marañón
RECRUITINGMadrid, 28007, Spain
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Hospital Universitario Parc Taulí
RECRUITINGBarcelona, 08208, Spain
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Hospital Universitario Virgen De La Victoria
RECRUITINGMálaga, 29010, Spain
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Hospital Universitario y Politécnico La Fe
RECRUITINGValencia, 46026, Spain
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Humanitas University
RECRUITINGRozzano, 20089, Italy
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Karadeniz Technical University, Farabi Hospital, Department of Gastroenterology
RECRUITINGTrabzon, 61080, Turkey (Türkiye)
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Kocaeli University Faculty of Medicine Gastroenterology and Hepatology Department
RECRUITINGKocaeli, 41100, Turkey (Türkiye)
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NIHR Birmingham BRC
RECRUITINGBirmingham, B15 2TT, United Kingdom
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Nottingham Digestive Diseases Centre and Biomedical Research Centre Nottingham University Hospitals NHS Trust, Queen's Medical Centre
RECRUITINGNottingham, NG7 2UH, United Kingdom
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Oxford University Hospitals NHS Foundation Trust
RECRUITINGOxford, United Kingdom
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Recep Tayyip Erdoğan University Training and Research Hospital, Department of Gastroenterology
RECRUITINGRize, 53020, Turkey (Türkiye)
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Royal Free London NHS Foundation Trust
RECRUITINGLondon, NW3 2QG, United Kingdom
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Royal Wolverhampton NHS Trust, New Cross Hospital
RECRUITINGWolverhampton, WV10 0QP, United Kingdom
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University Hospital Complex of Pontevedra & IIS Galicia South, Pontevedra
RECRUITINGPontevedra, 36071, Spain
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University Hospital Düsseldorf
RECRUITINGDüsseldorf, 40225, Germany
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University Hospital Marquez de Valdecilla, Santander
RECRUITINGSantander, 39008, Spain
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University Hospital Paolo Giaccone, University of Palermo
RECRUITINGPalermo, 90127, Italy
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University Hospital of Patras
RECRUITINGPátrai, 26504, Greece
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University Medical Center "Zvezdara"
RECRUITINGBelgrade, 11000, Serbia
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University of Leipzig
RECRUITINGLeipzig, 04103, Germany
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University of Padova, Department of Surgery, Oncology and Gastroenterology
RECRUITINGPadova, 35128, Italy
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University of Udine
RECRUITINGUdine, 33100, Italy
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Università di Milano-Bicocca, S.C. ASST Grande Ospedale Metropolitano Niguarda, Dipartimento di Medicina e Chirurgia, Epatologia e Gastroenterologia
RECRUITINGMilan, 20162, Italy
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Virgen del Rocio University Hospital
RECRUITINGSeville, 41013, Spain
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