Could a simple cream reduce the need for major mole removal surgery?
NCT ID NCT04999631
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether a topical cream called squaric acid dibutyl ester (SADBE) can safely reduce pigment-producing cells in large congenital moles before they are surgically removed. Thirty adults with these birthmarks will apply the cream or a placebo for several weeks before their planned excision. The goal is to see if the treatment lowers the number of melanocytes and lightens the mole, potentially making surgery easier or less extensive.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Squaric acid dibutyl ester (SADBE) applied as a topical solution
What this could lead to
If it works, this could point toward a non-surgical way to lighten or shrink congenital moles before removal, potentially reducing scarring or need for extensive surgery.
What could go wrong
This is a very early (Phase 1) trial with only 30 people, so it may not show clear benefit. The treatment is topical but could cause skin irritation or allergic reactions.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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