Could stem cells save limbs? new trial tests healing power for leg ulcers

NCT ID NCT06326203

Not yet recruiting Disease control Sponsor: UPECLIN HC FM Botucatu Unesp Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 1/2 trial tests whether a patient's own stem cells, taken from belly fat and grown in a lab, can heal leg ulcers caused by severe peripheral artery disease. 40 participants will either receive stem cell injections and a special cell-containing dressing, or standard hydrogel wound care. The study will track wound healing and safety over 120 days, aiming to find a new way to prevent amputations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: autologous mesenchymal stem cells (from the patient's own fat tissue)
What this could lead to: If successful, this could offer a new way to heal leg ulcers and reduce amputations in people with severe peripheral artery disease who have no other options.
What could go wrong: This is an early phase 1/2 trial with only 40 people, so results are preliminary. The treatment involves a surgical procedure and may not work for everyone; risks include infection or worsening of the ulcer.

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Conditions

The condition(s) this trial relates to.

Leg Ulcer limb ischemia peripheral arterial disease ulcer of lower limbs

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEG ULCER PERIPHERAL ARTERIAL DISEASE

More trials for these conditions

Other studies related to the condition(s) this trial covers.