Can a new Four-in-One vaccine match the gold standard for childhood protection?

NCT ID NCT07742644

Not yet recruiting Prevention Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study tests an investigational vaccine that combines protection against measles, mumps, rubella, and chickenpox (varicella) in a single shot. It will be given as a second dose to healthy children aged 4 to 6 years who have already received a first dose of a similar vaccine. The trial aims to see if the new vaccine produces a consistent immune response across different manufacturing lots and whether it works as well as an existing licensed vaccine. It will also check if the vaccine can be safely given at the same time as another routine childhood vaccine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an investigational combined measles, mumps, rubella, and varicella (MMRVNS) vaccine
What this could lead to: If successful, this could provide a new option for protecting children against four common childhood diseases with a single shot, potentially matching the effectiveness of existing vaccines.
What could go wrong: This is an early-stage trial, so the vaccine may not produce a strong enough immune response or could cause unexpected side effects. Results from this study will need further confirmation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chickenpox measles mumps infectious disease rubella

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MEASLES MEASLES-MUMPS-RUBELLA+CHICKENPOX VACCINE MUMPS RUBELLA VARICELLA (CHICKENPOX)

Contacts and locations

Locations

ACC Pediatric Research

Haughton, Louisiana, 71037, United States
Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611-2605, United States
Applied Research Center of Arkansas

Little Rock, Arkansas, 72212, United States
Atrium Health

Charlotte, North Carolina, 28203, United States
Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

Bari, Italy
Benchmark Research

Covington, Louisiana, 70433, United States
BioMD Clinical Research

Coral Gables, Florida, 33134, United States
Boeson Research MSO

Missoula, Montana, 59804, United States
Carolina Family Care

Summerville, South Carolina, 29486, United States
Center for Clinical Trials of Sacramento, Inc.

Sacramento, California, 95823, United States
Center for Clinical Trials of San Gabriel

West Covina, California, 91790, United States
Centro Clin-PR

Corozal, Puerto Rico
Century Research Institute Inc

Huntington Park, California, 90255, United States
Chang Gung Memorial Hospital, Linkou

Taoyuan City, Taiwan
Children's Clinic of Jonesboro, AR

Jonesboro, Arkansas, 72401, United States
China Medical University Hospital

Taichung, Taiwan
Clinica Mayo de Urgencias Medicas Cruz Blanca SRL

San Miguel de Tucumán, Argentina
Clinica Privada del Sol SA

Córdoba, Argentina
Clinica del Nino y la Familia de Mar del Plata

Mar del Plata, Argentina
Clinical Research Partners, LLC

Richmond, Virginia, 23236, United States
Complete Children's Health

Lincoln, Nebraska, 68516, United States
Complete Children's Health

Lincoln, Nebraska, 68522-1231, United States
D&H Pompano Research Center LLC

Margate, Florida, 33063, United States
Equipo Ciencia

Buenos Aires, Argentina
Finnish Vaccine Research, Espoo Clinic

Espoo, Finland
Finnish Vaccine Research, Helsinki South Clinic

Helsinki, Finland
Finnish Vaccine Research, Järvenpää Clinic

Jarvenpaa, Finland
Finnish Vaccine Research, Kokkola Clinic

Kokkola, Finland
Finnish Vaccine Research, Oulu Clinic

Oulu, Finland
Finnish Vaccine Research, Seinäjoki Clinic

Seinäjoki, Finland
Finnish Vaccine Research, Tampere Clinic

Tampere, Finland
Finnish Vaccine Research, Turku Clinic

Turku, Finland
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Rome, Italy
Helios Salud

Ciudad Autonoma Buenos Aires, Argentina
Hospital del Nino Jesus

San Miguel de Tucumán, Argentina
Instituto Medico Rio Cuarto

Río Cuarto, Argentina
Jefferson City Medical Group PC

Jefferson City, Missouri, 65109, United States
Kentucky Pediatric/ Adult Research

Bardstown, Kentucky, 40004, United States
MacKay Memorial Hospital Taipei Branch

Taipei, Taiwan
Marshfield Clinic Research Foundation, a Division of Marshfield Clinic, Inc

Marshfield, Wisconsin, 54449, United States
Matrix Clinical Research

Los Angeles, California, 90057, United States
Medical Research Partners

Ammon, Idaho, 83406, United States
Meharry Medical College

Nashville, Tennessee, 37208, United States
Midwest Children's Health Research Institute, LLC

Lincoln, Nebraska, 68504, United States
Midwest Children's Health Research Institute, LLC

Lincoln, Nebraska, 68505, United States
National Taiwan University Hospital

Taipei, Taiwan
Neighbors Clinical Research

Charleston, South Carolina, 29407, United States
Norton Childrens Research Institute

Louisville, Kentucky, 40202, United States
Ogden Clinic Canyon View

Ogden, Utah, 84404, United States
Ospedale D'Avanzo

Foggia, Italy
PAS Research

Tampa, Florida, 33613, United States
Pas Research

Edinburg, Texas, 78539, United States
Pediatric Associates

Houston, Texas, 77087, United States
Pediatric Research of Charlottesville, LLC

Charlottesville, Virginia, 22902, United States
Senders Pediatrics

Cleveland, Ohio, 44121-4243, United States
Taichung Veterans General Hospital

Taichung, Taiwan
Tanner Clinic Kaysville

Kaysville, Utah, 84037, United States
Tanner Clinic Layton Parkway

Layton, Utah, 84041, United States
Tekton Research - Beaumont, TX

Beaumont, Texas, 77706, United States
Tribe Clinical Research LLC/Parkside Pediatrics

Greenville, South Carolina, 29607, United States
Tribe Clinical Research LLC/Parkside Pediatrics

Simpsonville, South Carolina, 29681, United States
Velocity Clinical Research, Gulfport

Lafayette, Louisiana, 70508, United States

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