Can a single cream tackle both skin and nail psoriasis?
NCT ID NCT07725822
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether a daily application of roflumilast 0.3% cream can improve both chronic plaque psoriasis and moderate-to-severe nail psoriasis. People aged 12 and older with stable disease for at least 6 months apply the cream to affected nails and plaques daily for 24 weeks. The main goal is to measure changes in nail psoriasis severity from the start to week 24.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- roflumilast 0.3% topical cream
- What this could lead to
- If effective, this cream could offer a new daily treatment option for both skin plaques and nail psoriasis with a single application.
- What could go wrong
- This is a small, open-label trial with only 15 participants, so results may not apply broadly. Side effects from topical roflumilast are possible, including skin irritation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Modern Research Associates, PLLC
Dallas, Texas, 75231, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••