New gel aims to heal stubborn leg ulcers

NCT ID NCT07463365

Not yet recruiting Disease control Sponsor: Antoni Ribas Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a gel called LUT017 on chronic wounds like venous leg ulcers. The gel is applied once a week for up to 8 weeks to see if it's safe and might help wounds heal. About 12 to 18 adults with a leg wound that hasn't healed for at least 4 weeks will take part. The study first checks if standard bandages alone work, then treats eligible participants with the gel.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LUT017 gel (a topical BRAF inhibitor)
What this could lead to: If it works, this could point toward a new treatment for chronic wounds like venous leg ulcers that are hard to heal.
What could go wrong: This is a very early Phase 1 trial with only 18 people, so it's mainly checking safety. The gel may not help wounds heal, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

chronic ulcer of skin ulcer of lower limbs Varicose Ulcer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC NON-HEALING CUTANEOUS WOUNDS VENOUS LEG ULCER VLU

Contacts and locations

Locations

University of California, Los Angeles

Los Angeles, California, 90095, United States

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