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Gene therapy skin graft aims to heal wounds in 'Butterfly Children'

NCT ID NCT07717736

Not yet recruiting Disease control Sponsor: Abeona Therapeutics, Inc Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial evaluates a gene therapy skin graft called prademagene zamikeracel (pz-cel) for treating wounds in people with recessive dystrophic epidermolysis bullosa (RDEB), a severe genetic condition that causes fragile skin and chronic wounds. The study includes three parts: one tests a non-conforming version of the graft in RDEB patients, another collects extra skin samples from those receiving standard pz-cel, and a third assesses the graft in patient groups not included in earlier trials. The main goals are to see if wounds heal by at least 50% and if pain is reduced after six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a gene therapy skin graft called prademagene zamikeracel (pz-cel)
What this could lead to
If successful, this treatment could provide a way to heal chronic wounds in people with a severe form of epidermolysis bullosa, potentially reducing pain and improving quality of life.
What could go wrong
This is a Phase 4 study, so the treatment is already approved; however, it is being tested in specific patient groups not fully studied before, and results may vary. There is also a risk that the non-conforming product used in one part of the trial may be less effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dystrophic epidermolysis bullosa, dog epidermolysis bullosa epidermolysis bullosa dystrophica recessive dystrophic epidermolysis bullosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DYSTROPHIC EPIDERMOLYSIS BULLOSA (DEB) EPIDERMOLYSIS BULLOSA (EB) RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA (RDEB)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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