Engineered immune cells take on Hard-to-Treat scleroderma in landmark trial

NCT ID NCT07335562

Not yet recruiting Disease control Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can improve lung function and skin hardening better than current treatments for people with active systemic sclerosis, a rare autoimmune disease. About 92 adults with lung involvement will be randomly assigned to receive either the CAR T therapy or standard care. The main goal is to see if the new treatment can increase lung capacity and reduce disease activity.

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Conditions

The condition(s) this trial relates to.

systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC SCLEROSIS

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Local Institution - 0001

Denver, Colorado, 80218, United States
Local Institution - 0002

Charleston, South Carolina, 29425, United States
Local Institution - 0004

Milan, Milano, 20162, Italy
Local Institution - 0008

Seattle, Washington, 98109, United States
Local Institution - 0009

Málaga, 29011, Spain
Local Institution - 0012

Bron, 69500, France
Local Institution - 0016

Cologne, 50937, Germany
Local Institution - 0026

Sapporo, Hokkaido, 0608648, Japan
Local Institution - 0028

Erlangen, 91054, Germany
Local Institution - 0031

Strasbourg, Alsace, 67098, France
Local Institution - 0032

München, 80336, Germany
Local Institution - 0033

Tübingen, 72076, Germany
Local Institution - 0034

Ann Arbor, Michigan, 48109, United States
Local Institution - 0035

Scottsdale, Arizona, 85259, United States
Local Institution - 0037

Rochester, Minnesota, 55905, United States
Local Institution - 0038

Würzburg, 97080, Germany
Local Institution - 0042

Leipzig, 04103, Germany
Local Institution - 0046

Berlin, 10117, Germany
Local Institution - 0047

Basel, 4031, Switzerland
Local Institution - 0049

Bordeaux, 33076, France
Local Institution - 0052

Paris, 75679, France
Local Institution - 0057

Leuven, Vlaams-Brabant, 3000, Belgium
Local Institution - 0059

London, NW3 2QG, United Kingdom
Local Institution - 0060

Barcelona, 08907, Spain
Local Institution - 0061

Toulouse, Haute-Garonne, 31059, France
Local Institution - 0063

Leeds, West Yorkshire, LS8 7TF, United Kingdom
Local Institution - 0068

Bern, 3010, Switzerland
Local Institution - 0069

Miami, Florida, 33136, United States
Local Institution - 0074

Dallas, Texas, 75390, United States
Local Institution - 0078

Zurich, 8091, Switzerland
Local Institution - 0080

Liège, 4000, Belgium
Local Institution - 0082

Summit, New Jersey, 07901, United States
Local Institution - 0084

Worcester, Massachusetts, 01655, United States
Local Institution - 0088

Sherbrooke, Quebec, J1H 5N4, Canada
Local Institution - 0091

Sheffield, S10 2JF, United Kingdom
Local Institution - 0103

Rome, Lazio, 00168, Italy
Local Institution - 0104

Halifax, Nova Scotia, B3H2Y9, Canada
Local Institution - 0106

Milan, 20132, Italy
Local Institution - 0108

Pisa, Tuscany, 56126, Italy
Local Institution - 0117

Bunkyo-ku, Tokyo, 1138603, Japan
Local Institution - 0118

Okayama, 700-8558, Japan
Local Institution - 0123

Fukuoka, 812-8582, Japan
Local Institution - 0129

A Coruña, A Coruña [La Coruña], 15006, Spain
Local Institution - 0132

Yokohama, Kanagawa, 236-0004, Japan
Local Institution - 0136

Maebashi, 371-8511, Japan
Local Institution - 0137

Suita, Osaka, 565-0871, Japan
Local Institution - 0138

Barcelona, Catalunya [Cataluña], 08041, Spain
Local Institution - 0139

Chicago, Illinois, 60611, United States
Local Institution - 0140

London, London, City of, NW1 2PG, United Kingdom
Local Institution - 0141

Rennes, 35033, France
Local Institution - 0142

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0143

Pittsburgh, Pennsylvania, 15224, United States
Local Institution - 0144

Houston, Texas, 77030, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States

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