New drug combo aims to outsmart lymphoma resistance

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age greater than or equal to 18 years. 2. Confirmed diagnosis of mycosis fungoides (MF) or primary cutaneous anaplastic large cell lymphoma (pcALCL). 3. CD30 positive confirmed by skin biopsy (at least 2 lesion biopsies for MF patients, and at least 1 lesion biopsy for pcALCL patients). CD30 positivity is defined as greater than or equal to 10% of target lymphocytes showing CD30 membrane, cytoplasmic, and/or Golgi-like staining, with a staining intensity higher than the background staining of the corresponding negative control. 4. Prior treatment requirements: * pcALCL: Must have received ≥ 1 prior systemic therapy or radiotherapy. * MF: Must have received ≥ 1 prior systemic therapy. * Note: Patients must be chemotherapy-naïve. 5. Eastern Cooperative Oncology Group (ECOG) performance status score of less than or equal to 2. 6. Adequate hepatic, renal, and hematopoietic function. 7. Females of childbearing potential must be willing to use highly effective methods of contraception during the study and for 6 months after the last dose of study drug; or must be postmenopausal for greater than or equal to 1 year, or surgically sterile. 8. Males, even if surgically sterilized (i.e., post-vasectomy), must agree to use highly effective methods of contraception during the study and for 6 months after the last dose of study drug. 9. No cognitive or communication barriers; capable of understanding and willing to sign a written informed consent form (ICF), and willing to comply with the study visits and procedures. 10. Good venous access for required blood sampling. Exclusion Criteria: 1. Concomitant diagnosis of systemic anaplastic large cell lymphoma (sALCL), other non-Hodgkin lymphomas (except lymphomatoid papulosis), Sézary syndrome, or stage B2 disease. 2. Active central nervous system (CNS) involvement of lymphoma. 3. Prior treatment with chemotherapy, allogeneic or autologous stem cell transplantation. 4. Prior treatment with brentuximab vedotin or any B-cell lymphoma 2 (BCL-2) inhibitors. 5. Receipt of corticosteroids for cutaneous T-cell lymphoma (CTCL) or skin-directed therapies within 3 weeks prior to the first dose of study drug. 6. Receipt of antibody-directed therapy, immunoglobulin therapy, or other monoclonal antibodies within 12 weeks prior to the first dose of study drug. 7. History of other primary malignancies not in complete remission for greater than or equal to 3 years (exceptions: adequately treated carcinoma in situ of the cervix, non-melanoma skin cancer, squamous intraepithelial lesions, or localized prostate cancer with no evidence of recurrence based on prostate-specific antigen (PSA) levels). 8. Presence of severe organ dysfunction or history of major organ diseases, including: * Cardiac: Left ventricular ejection fraction (LVEF) less than 50%; unstable angina; acute myocardial infarction within the past 6 months; New York Heart Association (NYHA) class III-IV congestive heart failure; clinically significant arrhythmias. * Renal: Creatinine clearance ≤ 50 mL/min. * Hepatic: Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or alkaline phosphatase \> 3 × Upper Limit of Normal (ULN), or Total Bilirubin \> 1.5 × ULN. 9. Active liver or biliary disease (exceptions: Gilbert's syndrome, asymptomatic gallstones, liver involvement by lymphoma, or stable chronic liver disease assessed by the investigator). 10. History of severe cerebrovascular disease within the past 6 months, or current presence of symptomatic/sequelae cerebrovascular events. 11. History of pancreatitis or high-risk factors for pancreatitis. 12. Uncontrolled systemic bacterial, fungal, viral, or other severe infections. 13. Positive test for Human Immunodeficiency Virus (HIV) or Hepatitis B virus (positive HBsAg or HBcAb). 14. Known hypersensitivity to recombinant proteins, murine proteins, or any excipients of the study drugs. 15. Female patients who are pregnant, lactating, or planning to become pregnant within 6 months. 16. Presence of severe concurrent medical/psychiatric conditions that may compromise patient safety or compliance, or interfere with informed consent, study participation, or interpretation of results. 17. Any other conditions that, in the opinion of the investigator, make the patient unsuitable for study participation.