Can a lower dose of acne drug work just as well with fewer side effects?

NCT ID NCT07639073

Not yet recruiting Disease control Sponsor: Pakistan Institute of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne improvement and any side effects over the treatment period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Isotretinoin (also known as Accutane or Roaccutane)
What this could lead to: If successful, this could show that a lower dose of isotretinoin works just as well as the standard dose but with fewer side effects like dry skin and chapped lips.
What could go wrong: This is a small, early-phase trial (164 participants) in one country, so results may not apply to everyone. Lower doses might not clear acne as effectively, and side effects could still occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACNE VULGARIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACNE VULGARIS

Contacts and locations

Locations

Pakistan Institute of Medical Sciences(PIMS)

Islamabad, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.