Can a cholesterol cream repair the skin barrier better than standard urea cream?
NCT ID NCT07689435
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This study tests whether a cream containing 10% cholesterol improves skin barrier function and quality of life more than a standard 10% urea cream in people with autosomal recessive congenital ichthyosis (ARCI), a rare genetic condition causing dry, scaly skin. Each participant applies one cream to one side of the body and the other cream to the opposite side, allowing direct comparison. Researchers measure skin water loss, hydration, dryness, itching, and quality of life over the treatment period.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 10% cholesterol cream
- What this could lead to
- If cholesterol cream works better, it could offer a more targeted way to repair the skin barrier in people with ARCI, potentially reducing dryness and itching more effectively than current standard care.
- What could go wrong
- This is a small, early-stage study with only 24 participants, so results may not apply to everyone. Cholesterol cream might not outperform urea cream, or could cause skin irritation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institute of dermatology
Bangkok, Bangkok, 10330, Thailand
More trials for these conditions
Other studies related to the condition(s) this trial covers.