New hope for rare blood vessel disorders: everolimus trial launches

NCT ID NCT07477548

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests the drug everolimus in 67 people with vascular anomalies (abnormal blood vessels) that haven't responded to standard treatments. The goal is to shrink the lesions and improve symptoms. Participants take everolimus daily for 6 months, with doses adjusted by age and other medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Everolimus (a drug that blocks a protein called mTOR, which helps control cell growth)

What this could lead to

If it works, this could offer a new treatment option for people with severe vascular anomalies that haven't responded to other therapies.

What could go wrong

This is an early phase 2 trial with no control group, so results are uncertain. Everolimus can cause side effects like mouth sores, infections, and metabolic changes.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

arteriovenous hemangioma/malformation arteriovenous malformations of the brain familial multiple nevi flammei hemangioendothelioma hemangioma Kasabach-Merritt syndrome lymphangioma melanocytic nevus tufted angioma vascular malformation vascular neoplasm venous hemangioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

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