Brain AVM drug trial pulled before it began
NCT ID NCT06098872
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study aimed to see if the oral drug trametinib could improve the structure of brain arteriovenous malformations (AVMs) in adults before their scheduled surgery. The goal was to shrink the AVM or reduce risky features. However, the trial was withdrawn before enrolling any participants, so no results are available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Trametinib (oral tablet)
What this could lead to
If it had worked, trametinib might have made brain AVMs smaller or safer before surgery, potentially reducing surgical risks.
What could go wrong
The study was withdrawn before any participants were enrolled, so no data exist. Even if conducted, it was a small pilot with no guarantee of benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University Health Network
Toronto, Ontario, Canada