Pineapple enzyme gel could revolutionize wound care for leg ulcers

NCT ID NCT07692178

Not yet recruiting Disease control Sponsor: MediWound Ltd Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This phase 2 trial tests a gel called EscharEx, made from pineapple enzymes, on people with venous leg ulcers that have stubborn dead tissue. The gel is applied to the wound to break down and remove non-viable tissue, potentially speeding up healing. The study involves 20 adults and focuses on how the gel is absorbed, its safety, and how well it cleans the wound.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EscharEx (EX-03) – a gel containing pineapple-derived enzymes that break down dead tissue
What this could lead to: If successful, EscharEx could offer a faster, less painful way to clean venous leg ulcers, helping them heal more effectively.
What could go wrong: This is a small, early-phase study with only 20 participants, so results may not apply to everyone. The gel could cause irritation or fail to fully clean the wound.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcer of lower limbs Varicose Ulcer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENOUS LEG ULCER (VLU)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

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