Can a laser and diabetes drug erase dark skin patches?
NCT ID NCT07760181
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether combining fractional carbon dioxide laser treatment with a topical metformin cream works better than laser alone for acanthosis nigricans—dark, velvety patches on the neck. About 34 adults with this condition will have one side of their neck treated with the combination and the other side with laser only, to compare results. The study measures changes in the severity of the patches using a standard scoring system and a doctor's overall assessment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fractional carbon dioxide laser plus topical metformin
- What this could lead to
- If effective, this combination could offer a more effective treatment for acanthosis nigricans, a skin condition often linked to insulin resistance.
- What could go wrong
- This is a small early-phase study, so results may not be conclusive. Risks include skin irritation, scarring, or no added benefit from the metformin.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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