Can a skin cream replace a diabetes drug for dark patches?
NCT ID NCT07751549
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests three ways to treat acanthosis nigricans, a skin condition causing dark, thick patches often linked to insulin resistance and obesity. About 54 people with the condition will receive either oral metformin, a topical metformin cream, or a glycolic acid chemical peel. The study compares how well each treatment reduces the severity of the patches, aiming to see if the cream can match the pill's effectiveness with fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- oral metformin, topical metformin 30%, and glycolic acid 70% chemical peel
- What this could lead to
- If topical metformin works as well as oral metformin, it could offer a safer, more convenient treatment for acanthosis nigricans with fewer side effects.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. Chemical peels can cause irritation or pigmentation changes, and metformin may cause gastrointestinal issues.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Tanta University Hospitals
Tanta, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.