Can a precise nerve block stop shingles pain before it becomes chronic?

NCT ID NCT07732556

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial compares two ultrasound-guided nerve blocks — the midpoint transverse process to pleura (MTP) block and the erector spinae plane (ESP) block — for treating acute pain from shingles (herpes zoster) on the chest. About 90 adults with moderate to severe pain will receive one of the two blocks, which combine a numbing medication (bupivacaine) with an anti-inflammatory steroid (methylprednisolone). The goal is to see which block provides better pain relief and whether it can prevent postherpetic neuralgia, a chronic pain condition that can linger after the rash heals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a nerve block using bupivacaine and methylprednisolone
What this could lead to
If one block proves superior, it could offer a more effective way to control shingles pain and reduce the risk of lasting nerve pain.
What could go wrong
This is a small, early-stage comparison. Results may not apply to all patients, and nerve blocks carry risks like infection or bleeding.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Tanta University

    RECRUITING

    Tanta, El-Gharbia, 31527, Egypt

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