Drug combo aims to halt lung scarring in scleroderma
NCT ID NCT06549231
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial tests whether adding rituximab to standard mycophenolate mofetil (MMF) therapy can improve lung function in people with severe lung scarring caused by systemic sclerosis. About 102 adults with this condition will receive either rituximab infusions plus MMF or placebo infusions plus MMF. The main goal is to measure changes in forced vital capacity (a key lung function test) after 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rituximab and mycophenolate mofetil
What this could lead to
If it works, this combination could slow or stop lung damage in people with severe systemic sclerosis-related lung disease.
What could go wrong
This is a phase 3 trial, but the sample size is modest (102 people). The drugs may cause side effects like infections, and the benefit may not be large enough to change standard care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Tours
RECRUITINGTours, France
Contact Phone: •••-•••-•••• Email: •••••@•••••