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New psoriasis drug ORKA-001 tested for Long-Term safety

NCT ID NCT07449702

Recruiting now Disease control Sponsor: Oruka Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 06, 2026 · Updated 5 times

Summary

This study is testing the long-term safety and effectiveness of a drug called ORKA-001 for people with moderate-to-severe plaque psoriasis. It is an open-label extension, meaning everyone gets the drug, and it includes 240 adults who already completed a previous trial with ORKA-001. Researchers will track side effects and how well the drug controls psoriasis over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ORKA-001 (a drug given as an injection under the skin)
What this could lead to
If successful, this could confirm that ORKA-001 is safe and effective for long-term control of moderate-to-severe plaque psoriasis.
What could go wrong
This is an early-phase, open-label extension study with no placebo group, so results may not prove long-term benefit. Side effects are possible, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLAQUE PSORIASIS

Contacts and locations

Locations

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Fountain Valley, California, 92708, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Los Angeles, California, 90045, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    San Diego, California, 92123, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Santa Ana, California, 92701, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Santa Monica, California, 90403, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Cromwell, Connecticut, 06416, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Miami, Florida, 33126, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Rolling Meadows, Illinois, 60008, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Bowling Green, Kentucky, 42104, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Rockville, Maryland, 20850, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Boston, Massachusetts, 02111, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Detroit, Michigan, 48202, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    New York, New York, 10023, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    New York, New York, 10029, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Portland, Oregon, 97201, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Portland, Oregon, 97210, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Houston, Texas, 77004, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Norfolk, Virginia, 23502, United States

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Edmonton, Alberta, T5J 3S9, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Edmonton, Alberta, T6G 1C3, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Surrey, British Columbia, V3R 6A7, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    London, Ontario, N6H 5L5, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Markham, Ontario, L3P 1X3, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Peterborough, Ontario, K9J 5K2, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Toronto, Ontario, M4W 2N4, Canada

    Contact Email: •••••@•••••

  • Oruka Therapeutics Investigative Site

    RECRUITING

    Waterloo, Ontario, N2J 1C4, Canada

    Contact Email: •••••@•••••

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