Can a simple blood test predict leukemia risk after cancer therapy?
NCT ID NCT07675967
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, urine, stool, and tissue samples from 5,000 participants before and during therapy to track how CH changes over time. The goal is to build a tool that predicts who is at highest risk for developing therapy-related myeloid neoplasms (t-MNs), a serious blood cancer, and ultimately find ways to prevent it.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this research could lead to a risk prediction algorithm that identifies patients most likely to develop therapy-related leukemia, potentially guiding preventive strategies.
- What could go wrong
- This is an observational study, not a treatment trial. It may not directly change patient care, and the findings might not apply to all cancer types or treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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