LUNG CANCER (DIAGNOSIS)

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This study looks at whether finding and treating COPD early can help people who are also being evaluated for lung cancer. About 280 adults with breathing problems will get early COPD treatment or standard care. Researchers will track symptoms, weight, and exercise ability over 6 …

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use special processing and staining methods on tumor samples from 1,000 patients. The goal is to see cancer features more clearly than with standard 2D slides, which may…

This study looks at whether doctors need to change the needle between sampling different lymph nodes during a lung cancer staging procedure called EBUS-TBNA. About 30 people with suspected or confirmed lung cancer will have two rounds of staging: one with a fresh needle for each …

This study is testing a device called Inflammacheck that measures certain chemicals in your breath to see if it can help doctors tell the difference between lung cancer, other lung diseases, and healthy lungs. About 140 adults will take part, including people with lung cancer, pn…

This study looks at whether a blood test that analyzes DNA fragments (cfDNA fragmentomics) can accurately tell if lung nodules found on CT scans are cancerous or harmless. Researchers will enroll 240 adults with small to medium-sized lung nodules. If successful, this noninvasive …

This study compares three different lung biopsy techniques to see which one collects the best tumor samples for diagnosing lung cancer. Researchers will test jabbing-then-suction, suction-with-jabbing, and suction-only methods in 54 adults with suspected lung cancer. The goal is …

This study is testing a new blood test that measures telomeres (the protective caps on your DNA) to help doctors diagnose lung cancer. Researchers will compare results from 1,200 people—some with lung cancer and some without—to see if the test can accurately tell who has the dise…

This study tests whether giving people a direct referral for lung cancer screening from the emergency room, plus text message reminders, helps more high-risk smokers get screened. About 300 people aged 50-80 who smoke or quit recently will be split into two groups: one gets basic…

This study is testing whether a blood test, combined with artificial intelligence (AI), can help find lung cancer early in people with COPD (a lung condition often caused by smoking). Around 1,000 participants will give a blood sample, and the AI will analyze it to see who has a …

This study is testing a new test called FlowPath Lung that looks for lung cancer cells in sputum (phlegm). It is for people aged 50-80 who are at high risk for lung cancer and have a lung nodule between 6 and 30 mm. The goal is to see if this test can accurately detect early-stag…

This study tests whether a supplement from the Antrodia cinnamomea mushroom can improve quality of life for people with lung cancer who are receiving platinum-based chemotherapy. About 40 participants will take either the supplement or a placebo for 3 months, and researchers will…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start and stay in a telehealth counseling program. About 30 adults being treated for lung cancer at Penn M…

This study looks at whether yoga and mindfulness can improve the social, emotional, and physical well-being of people who have had lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect epigenetics—how our environment turns genes on o…

This study looks at whether a smartphone app can encourage mothers of young children to test their homes for radon, a radioactive gas that is the second-leading cause of lung cancer. About 100 mothers of kids aged 4 or younger will get a free radon test kit and use the app. Resea…

This study watches 300 lung cancer patients to see how they recover after one of two surgeries: removing a small part of the lung (sublobar resection) or a larger section (lobectomy). Patients use a digital device and answer questions about pain, cough, and other symptoms. The go…

This study looks at why some people develop dangerous blood clots (deep vein thrombosis) after lung cancer surgery. Researchers will follow 900 patients for 30 days after their operation, collecting medical data to find risk factors. They will then use machine learning to build a…

This study looks at how well a virtual oncology program works for veterans with lung, colorectal, prostate, or breast cancer. About 1,800 veterans will take part to see if using video or phone visits improves their care and lowers costs. The goal is to learn how to make cancer ca…

This study looks at whether giving a nerve block (paravertebral block) during chest surgery can help prevent problems like lung infections, trouble breathing, or fluid buildup. Researchers will track 500 adults having keyhole or robotic chest surgery to see if those who get the b…

This study looks at whether giving oxygen to the lung that is not being used for breathing during lung cancer surgery can lower inflammation and improve recovery. About 56 adults having lung cancer surgery will take part. Researchers will measure markers of oxygen shortage and in…

This study looks at a community-based program to help adults who often miss cancer screenings get tested for lung, breast, and prostate cancers at local resource spots. About 200 adults who meet screening guidelines will take part. The goal is to see if this approach increases sc…

This study is watching how lung cancer patients do when they get a drug called Tislelizumab in regular doctor visits, not in a strict research setting. About 240 people in Germany and Austria will take part. The goal is to see how long they live, how well the treatment works, and…

This study aims to uncover the molecular differences between the original lung tumor and cancer that has spread to other parts of the body. Researchers will analyze DNA from stored tumor samples of 25 adults with non-small cell lung cancer who are healthy enough for surgery. The …

This study looks at how immune cells behave in lung cancer, sarcoidosis, and COPD. Researchers want to understand why some people don't respond to immunotherapy. They will study samples from 425 people, including patients and healthy volunteers. The goal is to find better, more p…